3-Guanidinopropionic acid
- CAS No.
- 353-09-3
- Chemical Name:
- 3-Guanidinopropionic acid
- Synonyms
- β-Guanidinopropionic acid;3-GUANIDINOPROPIONIC ACID;3-Guanidinopropanoate;3-guanidinopropanoicacid;RGX-202;PNU-10483;Ompenaclid;beta-Guanidinopropio;Guanidine propionate;3-Guanidino Propionic
- CBNumber:
- CB4749112
- Molecular Formula:
- C4H9N3O2
- Molecular Weight:
- 131.13
- MDL Number:
- MFCD00045939
- MOL File:
- 353-09-3.mol
| Melting point | 222 °C (dec.)(lit.) |
|---|---|
| Boiling point | 299.1±42.0 °C(Predicted) |
| Density | 1.46±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | Aqueous Acid (Slightly), Water (Slightly, Heated) |
| form | Solid |
| pka | 4.22±0.10(Predicted) |
| color | White to Off-White |
| BRN | 1705262 |
| LogP | -1.680 (est) |
| CAS DataBase Reference | 353-09-3(CAS DataBase Reference) |
| FDA UNII | UL1984YRKA |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | AY3157500 | |||||||||
| HS Code | 29252900 | |||||||||
| NFPA 704 |
|
3-Guanidinopropionic acid price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | G6878 | 3-Guanidinopropionic acid | 353-09-3 | 1g | $71.6 | 2024-03-01 | Buy |
| Sigma-Aldrich | G6878 | 3-Guanidinopropionic acid | 353-09-3 | 5g | $264 | 2024-03-01 | Buy |
| Cayman Chemical | 16725 | 3-Guanidinopropionic Acid ≥98% | 353-09-3 | 1g | $50 | 2024-03-01 | Buy |
| Cayman Chemical | 16725 | 3-Guanidinopropionic Acid ≥98% | 353-09-3 | 5g | $178 | 2024-03-01 | Buy |
| Cayman Chemical | 16725 | 3-Guanidinopropionic Acid ≥98% | 353-09-3 | 500mg | $32 | 2024-03-01 | Buy |
3-Guanidinopropionic acid Chemical Properties,Uses,Production
Description
Guanidinopropionic acid is a white crystal that dissolves in water and is a creatine analog. Guanidinopropionic acid is a kind of amino acid derivatives. It is an important chemical raw material and intermediate. It exists in the serum, brain, liver, kidney and urine of mammals. It can improve insulin sensitivity and selectively reduce Adipose tissue weight can treat and prevent metabolic disorders, hyperglycemia, hyperinsulinemia, insensitivity to blood insulin, hyperlipidemia, hyperamylase, obesity and other symptoms.
Chemical Properties
White solid
Uses
3-Guanidinopropionic Acid is an acidic guanidine derivative that has been shown to ameliorate hyperglycemia in animal models of noninsulin-dependent diabetes.
Definition
ChEBI: 3-guanidinopropanoic acid is a guanidine compound bearing an N-(2-carboxyethyl) substituent. It is a creatine analogue that has been found to decreases plasma glucose levels It has a role as a hypoglycemic agent. It derives from a propionic acid. It is a tautomer of a 3-guanidinopropanoic acid zwitterion.
Synthesis
Using thiourea |?-alanine as a raw material, guanidinopropionic acid is prepared by a two-step alkylation reaction of nucleophilic substituted amine, the content is greater than 99.0%, and the total yield is 76.2%. The process is low cost, mild conditions, and easy operation, simple and suitable for industrial production.
References
[1] winder w w, hardie d g. amp-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes[j]. american journal of physiology-endocrinology and metabolism, 1999, 277(1): e1-e10.
[2] chaturvedi, r. k.,adhihetty, p.,shukla, s., et al. impaired pgc-1α function in muscle in huntington’s disease. human molecular genetics 18(16), 3048-3065 (2009).
[3] larsen s d, connell m a, cudahy m m, et al. synthesis and biological activity of analogues of the antidiabetic/antiobesity agent 3-guanidinopropionic acid: discovery of a novel aminoguanidinoacetic acid antidiabetic agent[j]. journal of medicinal chemistry, 2001, 44(8): 1217-1230.
[4] meglasson m d, wilson j m, yu j h, et al. antihyperglycemic action of guanidinoalkanoic acids: 3-guanidinopropionic acid ameliorates hyperglycemia in diabetic kkay and c57bl6job/ob mice and increases glucose disappearance in rhesus monkeys[j]. journal of pharmacology and experimental therapeutics, 1993, 266(3): 1454-1462.
3-Guanidinopropionic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12453 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15371 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8822 | 58 |
| Cangzhou Wanyou New Material Technology Co.,Ltd | 18631714998 | sales@czwytech.com | CHINA | 906 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
View Lastest Price from 3-Guanidinopropionic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-09-05 | beta-Guanidinopropionic acid
353-09-3
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2023-05-17 | 3-Guanidinopropionic Acid
353-09-3
|
US $5.00-2.00 / KG | 1KG | 99% | 10000kg | Hebei Guanlang Biotechnology Co,.LTD | |
 |
2022-02-21 | 3-Guanidinopropionic acid
353-09-3
|
US $0.00 / KG | 1KG | 98.2% | 100 tons | Honest Joy Holdings Limited
|
-
- beta-Guanidinopropionic acid
353-09-3
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- 3-Guanidinopropionic Acid
353-09-3
- US $5.00-2.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co,.LTD
-
- 3-Guanidinopropionic acid
353-09-3
- US $0.00 / KG
- 98.2%
- Honest Joy Holdings Limited
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