AC187
- CAS No.
- 151804-77-2
- Chemical Name:
- AC187
- Synonyms
- AC187;ACETYL-[ASN30 TYR32]-CALCITONIN FRAGMENT;AC-(ASN30,TYR32)-CALCITONIN (8-32) (SALMON I);Acetyl-(Asn??,Tyr??)-Calcitonin (8-32) (salmon I);ACETYL-(ASN30,TYR32)-CALCITONIN (8-32) (SALMON I);Acetyl-(Asn30,Tyr32)-Calcitonin (8-32) (salMon I) AC187;8-32-Calcitonin (salmon reduced), N-acetyl-30-L-asparagine-32-L-tyrosinamide-;AC-VAL-LEU-GLY-LYS-LEU-SER-GLN-GLU-LEU-HIS-LYS-LEU-GLN-THR-TYR-PRO-ARG-THR-ASN-THR-GLY-SER-ASN-THR-TYR-NH2;ACETYL-VAL-LEU-GLY-LYS-LEU-SER-GLN-GLU-LEU-HIS-LYS-LEU-GLN-THR-TYR-PRO-ARG-THR-ASN-THR-GLY-SER-ASN-THR-TYR-NH2;Acetyl-(Asn30,Tyr32)-Calcitonin (8-32) (salmon I) trifluoroacetate salt Ac-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Asn-Thr-Tyr-NH2 trifluoroacetate salt
- CBNumber:
- CB4752202
- Molecular Formula:
- C127H205N37O40
- Molecular Weight:
- 2890.26
- MDL Number:
- MFCD03093452
- MOL File:
- 151804-77-2.mol
AC187 price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1418 | Acetyl-[Asn30, Tyr32]-Calcitonin Fragment 8-32 trifluoroacetate salt ≥95% (HPLC) | 151804-77-2 | 1mg | $391 | 2024-03-01 | Buy |
| Tocris | 3419 | AC187 | 151804-77-2 | 500U | $338 | 2021-12-16 | Buy |
| Usbiological | 254508 | AC 187 | 151804-77-2 | 500ug | $616 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA109403 | Acetyl-(Asn30,Tyr32)-Calcitonin (8-32) (salmon I) trifluoroacetate salt Ac-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Asn-Thr-Tyr-NH2 trifluoroacetate salt | 151804-77-2 | 1mg | $920 | 2021-12-16 | Buy |
| ApexBio Technology | B5424 | AC187 | 151804-77-2 | 500ug | $497 | 2021-12-16 | Buy |
AC187 Chemical Properties,Uses,Production
Biological Activity
amylin is a 37-amino acid peptide co-secreted with insulin from pancreatic β-ells. the plasma concentration of amyline increases with nutrient stimuli. ac187 is a potent amylin antagonist
in vitro
ac187 potently competes for rat amylin binding at high affinity sites such as rat nucleus accumbens membranes which have been useful in developing a number of selective ligands, including ac187. the kd for amylin at this site is 28 pm, and the ki for ac187 is 79 pm. ac187 is relatively selective in competing for amylin binding, displacing amylin from nucleus accumbens membranes with over 400-fold greater potency [1].
in vivo
ac187 was able to inhibit metabolic responses to exogenous amylin in the intact animal. an infusion of ac187 that was itself without effect on lactate levels in anesthetized rats, inhibited by more than 90% the lactate increment evoked by infusions of rat amylin. other experiments have shown that ac187-induced amylin blockade action is surmountable by higher doses of amylin, indicative of a competitive antagonism [1].
storage
Store at -20°C
References
[1] young aa, gedulin b, gaeta ls, prickett ks, beaumont k, larson e, rink tj. selective amylin antagonist suppresses rise in plasma lactate after intravenous glucose in the rat. evidence for a metabolic role of endogenous amylin. febs lett. 1994 may 2;343(3):237-41.
AC187 Preparation Products And Raw materials
Raw materials
Preparation Products
AC187 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10248 | 58 |
| Cellmano Biotech Limited | 0551-65326643 18156095617 | info@cellmano.com | China | 999 | 58 |
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| Chengdu Youngshe Chemical Co., Ltd. | +8618108235634 | Cecilia@youngshechem.com | China | 2345 | 58 |
| Nanjing TGpeptide | +86-13347807150 +86-13347807150 | support@tgpeptide.com | China | 3279 | 58 |
| Zhejiang Hangyu API Co., Ltd | +8617531972939 | anna@api-made.com | China | 2944 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |