O-ACETYLSALICYLHYDROXAMIC ACID
- CAS No.
- 199854-00-7
- Chemical Name:
- O-ACETYLSALICYLHYDROXAMIC ACID
- Synonyms
- ACSHA;O-ASHA;AcSHA, O-ASHA;O-ACETYLSALICYLHYDROXAMIC ACID;N-(ACETYLOXY)-2-HYDROXY BENZAMIDE;Benzamide, N-(acetyloxy)-2-hydroxy-;Acetic Acid (2-Hydroxybenzoyl)azanyl Ester
- CBNumber:
- CB4754802
- Molecular Formula:
- C9H9NO4
- Molecular Weight:
- 195.17
- MDL Number:
- MFCD05863976
- MOL File:
- Mol file
O-ACETYLSALICYLHYDROXAMIC ACID price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 70263 | O-Acetyl Salicylhydroxamic Acid ≥98% | 199854-00-7 | 1mg | $19 | 2024-03-01 | Buy |
| Cayman Chemical | 70263 | O-Acetyl Salicylhydroxamic Acid ≥98% | 199854-00-7 | 5mg | $78 | 2024-03-01 | Buy |
| Cayman Chemical | 70263 | O-Acetyl Salicylhydroxamic Acid ≥98% | 199854-00-7 | 10mg | $138 | 2024-03-01 | Buy |
| Cayman Chemical | 70263 | O-Acetyl Salicylhydroxamic Acid ≥98% | 199854-00-7 | 50mg | $595 | 2024-03-01 | Buy |
| TRC | A187725 | O-AcetylsalicylhydroxamicAcid | 199854-00-7 | 25mg | $120 | 2021-12-16 | Buy |
O-ACETYLSALICYLHYDROXAMIC ACID Chemical Properties,Uses,Production
Chemical Properties
Cyrstalline Solid
Uses
An irreversible, non-selective inhibitor of COX-1 and COX-2.
Biological Activity
o-acetyl salicylhydroxamic acid (o-asha) is an irreversible, non-selective inhibitor of cox-1 and cox-2 [1].cyclooxygenase (cox) is the key enzyme required for the conversion of arachidonic acid to prostaglandins. cyclooxygenase enzymes have been involved in diverse physiological situations and disease processes ranging from inflammation to cancer. until now, two cyclooxygenase isoforms have been identified, cox-1 and cox-2. the cox-1 enzyme is produced constitutively (i.e., gastric mucosa) and cox-2 is inducible (i.e., sites of inflammation) [2].o-acetyl salicylhydroxamic acid (o-asha) inhibited the activity of ovine cox-1 in a time-dependent and irreversible manner with a 50% b/b0 value of approximately 4.5 mm [1]. o-acetyl salicylhydroxamic acid was a novel acetylating agent. o-acetyl salicylhydroxamic acid inhibited pge2 synthesis in vivo and blocked the cyclooxygenase activity of pghs in vitro. o-acetyl salicylhydroxamic acid elicited its effects via acetylation of ser-529 in the cyclooxygenase active site [1].
References
[1] loll p j, sharkey c t, o'connor s j, et al. o-acetylsalicylhydroxamic acid, a novel acetylating inhibitor of prostaglandin h2 synthase: structural and functional characterization of enzyme-inhibitor interactions[j]. molecular pharmacology, 2001, 60(6): 1407-1413.
[2] dubois r n, abramson s b, crofford l, et al. cyclooxygenase in biology and disease[j]. the faseb journal, 1998, 12(12): 1063-1073.
O-ACETYLSALICYLHYDROXAMIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
O-ACETYLSALICYLHYDROXAMIC ACID Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Duling International Trade Co. LTD | +8618032673083 | sales05@hbduling.cn | China | 15745 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8073 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55717 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |