CLOZAPINE N-OXIDE
- CAS No.
- 34233-69-7
- Chemical Name:
- CLOZAPINE N-OXIDE
- Synonyms
- CLOZAPINE N-OXIDE;Clozapine Impurity 16;Clozapine N-Oxide imp;Clozapine N-oxide (CNO);CNO (Clozapine N-oxide);Clozapine N-oxide[C0832];Clozapine N-oxide solution;CLOZAPINE N-OXIDE, 10 mM in DMSO;Clozapine N-oxide Methanol Adduct;Clozapine N-oxide dihydrochloride NEW
- CBNumber:
- CB4759216
- Molecular Formula:
- C18H19ClN4O
- Molecular Weight:
- 342.82
- MDL Number:
- MFCD00210190
- MOL File:
- 34233-69-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Clozapine N-oxide | C0832 | 5mg | $239 |
| Clozapine N-Oxide | C3891 | 25MG | $426 |
| Clozapine N-oxide ≥98% | 16882 | 1mg | $36 |
| Clozapine N-oxide ≥98% | 16882 | 5mg | $62 |
| Clozapine N-oxide hydrochloride ≥98% (HPLC), Water soluble Clozapine N-oxide | SML2304 | 5mg | $231 |
| More product size | |||
| Melting point | 190-248°C |
|---|---|
| Flash point | 9℃ |
| storage temp. | -20°C Freezer, Under Inert Atmosphere |
| solubility | Soluble in DMSO. |
| form | powder |
| pka | 6.86±0.20(Predicted) |
| color | Yellow |
| biological source | synthetic |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| InChI | InChI=1S/C18H19ClN4O/c1-23(24)10-8-22(9-11-23)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3 |
| InChIKey | OGUCZBIQSYYWEF-UHFFFAOYSA-N |
| SMILES | N1=C(N2CC[N+]([O-])(C)CC2)C2=CC=CC=C2NC2=CC=C(Cl)C=C12 |
| FDA UNII | MZA8BK588J |
| UNSPSC Code | 12352119 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H336 | |||||||||
| Precautionary statements | P301+P310+P330 | |||||||||
| Hazard Codes | Xn,T,F | |||||||||
| Risk Statements | 22-36/37/38-39/23/24/25-23/24/25-11 | |||||||||
| Safety Statements | 26-36-45-36/37-16-7 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | HP1760000 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29335990 | |||||||||
| NFPA 704 |
|
CLOZAPINE N-OXIDE price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C0832 | Clozapine N-oxide | 34233-69-7 | 5mg | $239 | 2025-07-31 | Buy |
| TCI Chemical | C3891 | Clozapine N-Oxide | 34233-69-7 | 25MG | $426 | 2025-07-31 | Buy |
| Cayman Chemical | 16882 | Clozapine N-oxide ≥98% | 34233-69-7 | 1mg | $36 | 2024-03-01 | Buy |
| Cayman Chemical | 16882 | Clozapine N-oxide ≥98% | 34233-69-7 | 5mg | $62 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML2304 | Clozapine N-oxide hydrochloride ≥98% (HPLC), Water soluble Clozapine N-oxide | 34233-69-7 | 5mg | $231 | 2025-07-31 | Buy |
CLOZAPINE N-OXIDE Chemical Properties,Uses,Production
Description
Clozapine-N-oxide (34233-69-7) is a clozapine?metabolite1?which is pharmacologically inert2. Agonist at human muscarinic designer receptors known as DREADDs, (designer receptors exclusively activated by designer drug).2?May be used to control grafted human pluripotent stem cell-derived neurons engineered to express DREADDs.3,4??Numerous other applications.5,6
Chemical Properties
Yellow Solid
Uses
Clozapine N-oxide has been used:
- for the activation of human M4 muscarinic (hM4Di) in primary motor cortex
- for inducing in vivo chemogenetic manipulation and impairing locomotor activity in Th-cre transgenic mice
- in behavioral testing in mice and for stimulating (HEK293) cells
Uses
A 5-HT2 antagonist. A major metabolite of clozapine that can be monitored by HPLC. Possesses little or no activity towards serotonin receptors
Definition
ChEBI: Clozapine N-oxide is a dibenzodiazepine.
General Description
Clozapine N-oxide (CNO), inactive from of clozapine drug, activates G-protein-coupled receptors (GPCRs). CNO serves as a synthetic ligand for engineered human muscarinic receptor. It elicits clozapine-like effects upon metabolic conversion. Clozapine conversion to CNO favors its passage through blood-brain barrier.
Biochem/physiol Actions
5-HT2 serotonin receptor antagonist; major metabolite of clopazine that can be monitored by HPLC.
storage
Room temperature (desiccate)
References
[1] BIRGIT EIERMANN. The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine[J]. British journal of clinical pharmacology, 2003, 44 5: 439-446. DOI:10.1046/j.1365-2125.1997.t01-1-00605.x
[2] BLAINE N ARMBRUSTER. Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2007: 5163-5168. DOI:10.1073/pnas.0700293104
[3] YUEJUN CHEN. Chemical Control of Grafted Human PSC-Derived Neurons in a Mouse Model of Parkinson’s Disease.[J]. Cell stem cell, 2016, 18 6: 817-826. DOI:10.1016/j.stem.2016.03.014
[4] ELENA M VAZEY Gary A J. Designer receptors: therapeutic adjuncts to cell replacement therapy in Parkinson’s disease.[J]. Journal of Clinical Investigation, 2014, 124 7: 2858-2860. DOI:10.1172/jci76833
[5] JUAN L. GOMEZ. Chemogenetics revealed: DREADD occupancy and activation via converted clozapine[J]. Science, 2017, 357 6350. DOI:10.1126/science.aan2475
[6] CATHERINE A. MARCINKIEWCZ. Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala[J]. Nature, 2016, 537 7618: 97-101. DOI:10.1038/nature19318
CLOZAPINE N-OXIDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sichuan Zhuoyu Yantang Technology Co., Ltd. | +8613288715578 | sales@sichuanzyyt.com | China | 12242 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29799 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Baoji Guokang Healthchem Co., Ltd. | +86-0917-3909592 +86-13892490616 | gksales1@gk-bio.com | China | 9230 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12373 | 58 |
| Alfa Chemistry | +1-5166625404; | Info@alfa-chemistry.com | United States | 20405 | 58 |
View Lastest Price from CLOZAPINE N-OXIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-11-05 | Clozapine N-Oxide
34233-69-7
|
US $30.00-76.00 / mg | 98.65% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-08-08 | Clozapine Noxide
34233-69-7
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Sichuan Zhuoyu Yantang Technology Co., Ltd. | |
 |
2021-07-13 | Clozapine N-oxide
34233-69-7
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Clozapine N-Oxide
34233-69-7
- US $30.00-76.00 / mg
- 98.65%
- TargetMol Chemicals Inc.
-
- Clozapine Noxide
34233-69-7
- US $0.00 / KG
- 99%
- Sichuan Zhuoyu Yantang Technology Co., Ltd.
-
- Clozapine N-oxide
34233-69-7
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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