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Yohimbine hydrochloride

Overview Other actions Side effects Mechanism of action Pharmacokinetics
Yohimbine hydrochloride
Yohimbine hydrochloride structure
CAS No.
65-19-0
Chemical Name:
Yohimbine hydrochloride
Synonyms
Yobinol;Tosanpin;Yohydrol;GyniMbine;Menolysin;antagonil;Yuhengbin;(16α,17α)-;ParkiMbine;YOHIMBE HCL
CBNumber:
CB4768636
Molecular Formula:
C21H27ClN2O3
Formula Weight:
390.9
MOL File:
65-19-0.mol

Yohimbine hydrochloride Properties

Melting point:
288-290 °C (dec.)(lit.)
alpha 
99 º (c=1%, H2O, dry subst)
refractive index 
103 ° (C=1, H2O)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
H2O: 10 mg/mL
form 
powder
color 
white to off-white
optical activity
[α]/D 100±5°, c = 1 in H2O
Sensitive 
Light Sensitive
Merck 
14,10102
InChIKey
PIPZGJSEDRMUAW-VJDCAHTMSA-N
CAS DataBase Reference
65-19-0(CAS DataBase Reference)
FDA UNII
NB2E1YP49F
EPA Substance Registry System
Yohimbine hydrochloride (65-19-0)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H310-H330-H300
Precautionary statements  P301+P310a-P304+P340-P320-P330-P405-P501a
Hazard Codes  T
Risk Statements  23/24/25-33-23/24
Safety Statements  22-36/37/39-45-24/25
RIDADR  UN 1544 6.1/PG 2
WGK Germany  3
RTECS  ZG1015000
TSCA  Yes
HazardClass  6.1(a)
PackingGroup  II
HS Code  29339900

Yohimbine hydrochloride price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 49768 Yohimbine hydrochloride analytical standard 65-19-0 50mg $73 2020-08-18 Buy
Sigma-Aldrich Y0000656 Yohimbine hydrochloride European Pharmacopoeia (EP) Reference Standard 65-19-0 $190 2021-03-22 Buy
Sigma-Aldrich 1724000 Yohimbine hydrochloride United States Pharmacopeia (USP) Reference Standard 65-19-0 200mg $366 2021-03-22 Buy
TCI Chemical Y0002 Yohimbine Hydrochloride 65-19-0 25G $261 2021-03-22 Buy
TCI Chemical Y0002 Yohimbine Hydrochloride 65-19-0 5G $77 2021-03-22 Buy

Yohimbine hydrochloride Chemical Properties,Uses,Production

Overview

Yohimbine hydrochloride is an α2-adrenergic receptor antagonist and increases the firing rate of the locus coeruleus with a resultant increase in sympathetic outflow (Redmond, 1987). Oral and intravenous yohimbine causes an increase in MHPG and blood pressure in healthy human subjects (Charney et al., 1982d; Goldberg et al., 1986). Depressed patients demonstrate an increased cortisol and blood pressure response to intravenous yohimbine compared with healthy subjects, while plasma MHPG is not significantly different between the two groups of subjects (Heninger et al., 1988). The effects of acute or chronic antidepressant treatments on the neuroendocrine or behavioural responses to yohimbine in depressed patients have not been studied.

Other actions

Yohimbine exerts a stimulant effect on mood and may increase blood pressure at higher doses. Yohimbine may also have mild antidiuretic action, possibly due to release of antidiuretic hormone.

Side effects

Yohimbine hydrochloride has been associated with high blood pressure, increased heart rate, headache, anxiety, dizziness, nausea, vomiting, tremors, and sleeplessness. It can be dangerous if taken in large doses or for long periods of time. It should not be taken in combination with monoamine oxidase (MAO) inhibitors, as effects may be additive.
Yohimbe should be used with caution when taken with medicines for high blood pressure, tricyclic antidepressants, or phenothiazines. People with kidney problems and people with psychiatric conditions should not use yohimbe. Women who are pregnant or breastfeeding should not take yohimbe.
The Journal of Medical Toxicology reports an instance of refractory priapism associated with ingestion of yohimbe extract, and there are other scattered reports of adverse reactions. However, may studies report it to be generally well tolerated.

Mechanism of action

Yohimbine hydrochloride is a pre-synaptic alpha 2-adrenergic blocking agent. The exact mechanism for its use in impotence has not been fully elucidated. However, yohimbine may exert its beneficial effect on erectile ability through blockade of central alpha 2-adrenergic receptors producing an increase in sympathetic drive secondary to an increase in norepinephrine release and in firing rate of cells in the brain noradrenergic nuclei.Yohimbine-mediated norepinephrine release at the level of the corporeal tissues may also be involved. In addition, beneficial effects may involve other neurotransmitters such as dopamine and serotonin and cholinergic receptors.

Pharmacokinetics

Yohimbine hydrochloride—an α2-adrenoceptor antagonist that is approved for treatment of erectile dysfunction—may increase BP.1,2,In normal volunteers and in patients with panic disorders, oral administration at doses used clinically may slightly increase BP.1 However, in hypertensive patients oral yohimbine was reported to induce a significant increase in mean arterial pressure.The magnitude of the pressor response was related to baseline norepinephrine levels and to the yohimbine-induced increment in plasma norepinephrine levels.Thus yohimbine increases BP by stimulation of the sympathetic nervous outflow, and the drug should be administered with caution to patients with evidence for increased basal sympathetic outflow or those undergoing concurrent treatment with tricyclic antidepressants or other drugs that interfere with neuronal uptake or metabolism of norepinephrine.

Chemical Properties

Yohimbine hydrochloride is white to slightly yellow powder

Uses

Indole alkaloid with α2-adrenergic blocking activity. Mydriatic. Used in the treatment of neurological disorders.

Uses

alpha adrenergic blocker, mydriatic, antidepressant

Uses

vasodilator, neuromodulator

Uses

a2-adrenergic antagonist, used for erectile dysfunction

Uses

Erectile dysfunction & Mydriatic agent

Uses

An α2-adrenoceptor antagonist

Uses

Pharmacological probe for the study of a2-adrenoceptor.

Veterinary Drugs and Treatments

Yohimbine is indicated to reverse the effects of xylazine in dogs, but it is being used clinically in several other species as well.
Yohimbine may be efficacious in reversing some of the toxic effects associated with other agents (e.g., amitraz) and can be used prophylactically before amitraz dips.

Yohimbine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Yohimbine hydrochloride Suppliers

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View Lastest Price from Yohimbine hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-12-07 Yohimbine hydrochloride
65-19-0
US $15.08-1.69 / g 1KG 99% 1000kg/month Shanxi Lianxu New Material Co., LTD
2021-12-07 Yohimbine HCL
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2021-12-07 Yohimbine hydrochloride
65-19-0
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD

Yohimbine hydrochloride Spectrum


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