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Yohimbine hydrochloride

Chemical Name:
Yohimbine hydrochloride
YOHIMBINE HCL;YOHIMBE HCL;Corynante Yohimbe;Yobinol;Tosanpin;Yohydrol;GyniMbine;Menolysin;antagonil;Yuhengbin
Molecular Formula:
Molecular Weight:
MDL Number:
MOL File:
Modify Date:2023-05-25

Yohimbine hydrochloride Properties

Melting point 288-290 °C (dec.)(lit.)
alpha 99 º (c=1%, H2O, dry subst)
refractive index 103 ° (C=1, H2O)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility H2O: 10 mg/mL
form powder
color white to off-white
optical activity [α]/D 100±5°, c = 1 in H2O
Sensitive Light Sensitive
Merck 14,10102
SMILES N1C2=C(C=CC=C2)C2=C1[C@@]1(C[C@]3([C@](CC[C@@H]([C@@H]3C(OC)=O)O)([H])CN1CC2)[H])[H].[H]Cl |&1:9,11,12,15,16,r|
LogP 2.201 (est)
CAS DataBase Reference 65-19-0(CAS DataBase Reference)
EPA Substance Registry System Yohimbine hydrochloride (65-19-0)


Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
Signal word  Danger
Hazard statements  H300+H330
Precautionary statements  P260-P264-P270-P271-P284-P304+P340+P310
Hazard Codes  T
Risk Statements  23/24/25-33-23/24
Safety Statements  22-36/37/39-45-24/25
RIDADR  UN 1544 6.1/PG 2
WGK Germany  3
RTECS  ZG1015000
HazardClass  6.1(a)
PackingGroup  II
HS Code  29339900

Yohimbine hydrochloride price More Price(42)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHL82685 Yohimbine hydrochloride phyproof? Reference Substance 65-19-0 100MG $297 2023-01-07 Buy
Sigma-Aldrich PHR3265 Yohimbine Hydrochloride pharmaceutical secondary standard, certified reference material 65-19-0 500MG $151 2022-05-15 Buy
Sigma-Aldrich 5.04777 Yohimbine Hydrochloride - CAS 65-19-0 - Calbiochem Yohimbine Hydrochloride is a potent antagonist for α?-adrenoceptors, α2B and α2C receptors respectively). 65-19-0 1G $63.1 2022-05-15 Buy
Sigma-Aldrich 49768 Yohimbine hydrochloride analytical standard 65-19-0 50mg $85.6 2022-05-15 Buy
Sigma-Aldrich 1724000 Yohimbine hydrochloride United States Pharmacopeia (USP) Reference Standard 65-19-0 200mg $400 2022-05-15 Buy
Product number Packaging Price Buy
PHL82685 100MG $297 Buy
PHR3265 500MG $151 Buy
5.04777 1G $63.1 Buy
49768 50mg $85.6 Buy
1724000 200mg $400 Buy

Yohimbine hydrochloride Chemical Properties,Uses,Production


Yohimbine hydrochloride is an α2-adrenergic receptor antagonist and increases the firing rate of the locus coeruleus with a resultant increase in sympathetic outflow (Redmond, 1987). Oral and intravenous yohimbine causes an increase in MHPG and blood pressure in healthy human subjects (Charney et al., 1982d; Goldberg et al., 1986). Depressed patients demonstrate an increased cortisol and blood pressure response to intravenous yohimbine compared with healthy subjects, while plasma MHPG is not significantly different between the two groups of subjects (Heninger et al., 1988). The effects of acute or chronic antidepressant treatments on the neuroendocrine or behavioural responses to yohimbine in depressed patients have not been studied.
Yohimbine hydrochloride

Side effects

Yohimbine hydrochloride has been associated with high blood pressure, increased heart rate, headache, anxiety, dizziness, nausea, vomiting, tremors, and sleeplessness. It can be dangerous if taken in large doses or for long periods of time. It should not be taken in combination with monoamine oxidase (MAO) inhibitors, as effects may be additive.
Yohimbe should be used with caution when taken with medicines for high blood pressure, tricyclic antidepressants, or phenothiazines. People with kidney problems and people with psychiatric conditions should not use yohimbe. Women who are pregnant or breastfeeding should not take yohimbe.
The Journal of Medical Toxicology reports an instance of refractory priapism associated with ingestion of yohimbe extract, and there are other scattered reports of adverse reactions. However, may studies report it to be generally well tolerated.

Mechanism of action

Yohimbine hydrochloride is a pre-synaptic alpha 2-adrenergic blocking agent. The exact mechanism for its use in impotence has not been fully elucidated. However, yohimbine may exert its beneficial effect on erectile ability through blockade of central alpha 2-adrenergic receptors producing an increase in sympathetic drive secondary to an increase in norepinephrine release and in firing rate of cells in the brain noradrenergic nuclei.Yohimbine-mediated norepinephrine release at the level of the corporeal tissues may also be involved. In addition, beneficial effects may involve other neurotransmitters such as dopamine and serotonin and cholinergic receptors.


Yohimbine hydrochloride—an α2-adrenoceptor antagonist that is approved for treatment of erectile dysfunction—may increase BP.1,2,In normal volunteers and in patients with panic disorders, oral administration at doses used clinically may slightly increase BP.1 However, in hypertensive patients oral yohimbine was reported to induce a significant increase in mean arterial pressure.The magnitude of the pressor response was related to baseline norepinephrine levels and to the yohimbine-induced increment in plasma norepinephrine levels.Thus yohimbine increases BP by stimulation of the sympathetic nervous outflow, and the drug should be administered with caution to patients with evidence for increased basal sympathetic outflow or those undergoing concurrent treatment with tricyclic antidepressants or other drugs that interfere with neuronal uptake or metabolism of norepinephrine.

Chemical Properties

white to slightly yellow powder, slightly fragrant, slightly bitter taste, easily soluble in chloroform, soluble in methanol, ethanol, slightly soluble in water.


Yohimbine hydrochloride is an Indole alkaloid with α2-adrenergic blocking activity. It is an alpha adrenergic blocker, mydriatic, antidepressant that used in the treatment of neurological disorders and erectile dysfunction.


Yohimbine hydrochloride is an α2-adrenergic receptor antagonist. It blocks the central α2-adrenegic receptors in the brain, thus preventing and reducing the effects of xylazine, an α2-adrenergic agonist. The sedative effects and respiratory depression that accompany xylazine administration are both antagonized and reversed by yohimbine. Yohimbine hydrochloride also produces an antidiuretic effect, and increases heart rate and blood pressure.

General Description

Yohimbine hydrochloride is an indole alkaloid derived from the tree bark. It is an antagonist of α2-adrenergic receptors in the brain, reducing the effects of xylazine, which is an α2-adrenergic agonis.

Biochem/physiol Actions

Yohimbine is derived from the Coryanthe yohimbe tree cortex. It is an alkaloid. Yohimbine hydrochloride is an α2-adrenergic receptor antagonist. It blocks the central α2-adrenergic receptors in the brain, thus preventing and reducing the effects of xylazine, an α2-adrenergic agonist. The sedative effects and respiratory depression that accompany xylazine administration are both antagonized and reversed by yohimbine. Yohimbine hydrochloride also produces an antidiuretic effect, and increases heart rate and blood pressure. It is useful in treating erectile dysfunction and promotes sexual functioning.

Veterinary Drugs and Treatments

Yohimbine is indicated to reverse the effects of xylazine in dogs, but it is being used clinically in several other species as well.
Yohimbine may be efficacious in reversing some of the toxic effects associated with other agents (e.g., amitraz) and can be used prophylactically before amitraz dips.

Yohimbine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 479)Suppliers
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View Lastest Price from Yohimbine hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Yohimbine HCL pictures 2023-05-31 Yohimbine HCL
US $1360.00 / kg 1kg 99.99% 2 tons Wuhan Cell Pharmaceutical Co., Ltd
Yohimbine Hydrochloride pictures 2023-05-31 Yohimbine Hydrochloride
US $9.39-1350.00 / g 1g 99% 100kg Wuhan Cell Pharmaceutical Co., Ltd
Yohimbine Hydrochloride pictures 2023-05-30 Yohimbine Hydrochloride
US $1.00 / g 1g 99.98% 50000 Doublewin Biological Technology Co., Ltd
  • Yohimbine HCL pictures
  • Yohimbine HCL
  • US $1360.00 / kg
  • 99.99%
  • Wuhan Cell Pharmaceutical Co., Ltd
17-HYDROXYYOHIMBAN-16-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE 17A-HYDROXYYOHIMBAN-16A-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE YOHIMBINE HYDROCHLORIDE QUERBRACHINE 17alpha)-alph Yohimban-16-alpha-carboxylic acid, 17-alpha-hydroxy, methyl ester, monohydrochloride 17alpha-Hydroxyyohimban-16-carboxylic acid methyl ester hydrochloride Yohimbine hydrochloride,99% YOHIMBINE HYDROCHLORIDE EXTRACT Yohimbine Hydrochloride (200 mg) YohiMbine hydrochloride, 99% 5GR (16α,17α)- YohiMbine hydrochloride API YohiMbine hydrochloride (Antagonil) GyniMbine Menolysin ParkiMbine Tosanpin Yobinol Yohydrol YohiMbine(Corynine,Aphrodine) antagonil yohimban-16-alpha-carboxylicacid,17-alpha-hydroxy-,methylester,hydrochlori yohimban-16-carboxylicacid,17-hydroxy-,methylester,monohydrochloride,(16 yohimbinhydrochloride YOHIMBINE F & D VERSION FOR HUMAN USE*HY DROCHLORIDE YOHIMBINE F & D VERSION FOR VETERINARY U Yohimbine146-48-5/Hcl YohimbineHcl99% Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, monohydrochloride, (16.alpha.,17.alpha.)- YOHIMBINEHYDROCHLORIDE,USP YohiMban-16-carboxylicacid,17-hydroxy-,Methyl ester, hydrochloride (1:1), (16a,17a)- Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, hydrochloride (1:1), (16α,17α)- Yohimbe Bark 1-(3,4-dimethoxybenzyl)-4-(2-methoxyphenyl)piperazine hydrochloride(1:1) CORYNINE HYDROCHLORIDE APHRODINE HYDROCHLORIDE APHROSOL HYDROCHLORIDE corynante yohimbe extract IN STOCK YOHIMBINE HYDROCHLORIDE CAS NO.65-19-0 YOHIMBINE HYDROCHLORIDE CAS NO.65-19-0 Yohimbine hydrochloride Solution, 100ppm Yohimbine HCL 98% Yohimbine Hydrochloride Standard Yohimbine hydrochloride CRS Yuhengbin Yohimbine hydrochloride USP/EP/BP Yohimbine hydrochloride,Yohimbine HCL Yohimbe hydrochloride Yohimbine hydrochloride, ≥98% Yohimbine Hydrochloride extrapure, 99% Yohimbine Hydrochloride (1724000) YOHIMBE HCL YOHIMBINE HCL Corynante Yohimbe 17α-hydroxy-20α-yohimban-16β-carboxylic acid methyl ester 65-19-0 65-69-9