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TACROLIMUS

TACROLIMUS
TACROLIMUS structure
CAS No.
109581-93-3
Chemical Name:
TACROLIMUS
Synonyms
FK-506;Tacarolimus;tacrolimushydrate;FK-506 MONOHYDRATE;Tacrolimus (150 mg);tsukubaenolidehydrate;Tacrolimus monohydrate;Tacrolimus monohydroate;FK-506 monohydrate, >=98%;Tacrolimus /FK506 monohydrate
CBNumber:
CB4772400
Molecular Formula:
C44H69NO12
Formula Weight:
822.04
MOL File:
109581-93-3.mol

TACROLIMUS Properties

Melting point:
127-129°
alpha 
D23 -84.4° (c = 1.02 in chloroform)
storage temp. 
−20°C
solubility 
DMSO: soluble20mg/mL
form 
powder
Merck 
14,9025
InChIKey
NWJQLQGQZSIBAF-MLAUYUEBSA-N
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P310+P330-P301+P310
Hazard Codes  T
Risk Statements  25
Safety Statements  45
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  KD4201200
HazardClass  6.1
PackingGroup  III
HS Code  2934990002
Toxicity LD50 i.p. in mice: >200 mg/kg (Kino); LD50 in male, female rats (mg/kg): 57.0, 23.6 i.v.; 134, 194 orally (Ohara)

TACROLIMUS price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich F4679 FK-506 monohydrate ≥98% (HPLC) 109581-93-3 5mg $210 2019-12-02 Buy
Sigma-Aldrich 1642802 Tacrolimus United States Pharmacopeia (USP) Reference Standard 109581-93-3 150mg $1663.55 2019-12-02 Buy
TCI Chemical M2258 Tacrolimus Monohydrate >80.0%(HPLC) 109581-93-3 10mg $231 2019-12-02 Buy
TCI Chemical M2258 Tacrolimus Monohydrate >80.0%(HPLC) 109581-93-3 50mg $808 2019-12-02 Buy
Sigma-Aldrich PHR1809 Tacrolimus Pharmaceutical Secondary Standard; Certified Reference Material 109581-93-3 150mg $1663.55 2019-12-02 Buy

TACROLIMUS Chemical Properties,Uses,Production

Uses

immune suppressant, antifungal

Definition

ChEBI: A hydrate that is the monohydrate form of tacrolimus.

Biological Activity

Potent calcineurin (protein phosphatase 2B) inhibitor that requires FK 506-binding protein 12 (FKBP12) for activity (IC 50 = 3 nM). Inhibits secretion of IL-1, IL-2 (IC 50 = 1 nM), IL-3, IL-4, IL-6 (IC 50 = 35 nM), GM-CSF, TNF α (IC 50 = 10 nM), IFN γ and Myc from activated T-cells in vitro . Exhibits potent immunosuppressive, neuroprotective and anticonvulsant activity in vivo .

Safety Profile

A poison by ingestion and intravenous routes. When heated to decomposition it emits toxic vapors of NOx.

TACROLIMUS Preparation Products And Raw materials

Raw materials

Preparation Products


TACROLIMUS Suppliers

Global( 131)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 568 55
Hebei Chisure Biotechnology Co., Ltd.
+8613292890173
0311 66567340 luna@speedgainpharma.com CHINA 1011 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30050 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28235 58
Zhonglan Industry Co., Ltd.
(86) 531-82956570
(86) 531-82956571 sales@zhonglanindustry.com CHINA 4895 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930501651
whatsapp: +8619930501651 breeduan@crovellbio.com CHINA 2453 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6372 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23047 58
BOC Sciences
1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20039 58
Beijing Yibai Biotechnology Co., Ltd
0086-182-6772-3597
sales03@yibaibiotech.com CHINA 420 58

View Lastest Price from TACROLIMUS manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-05 TACROLIMUS
109581-93-3
US $10.00 / KG 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.
2019-12-25 TACROLIMUS
109581-93-3
US $0.00-0.00 / KG 5mg 99% 2000tons Shaanxi Dideu Medichem Co. Ltd
2019-08-16 Tacrolimus monohydrate
109581-93-3
US $0.00-0.00 / KG 1g 99% 20kg/month Beijing Yibai Biotechnology Co., Ltd

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