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TACROLIMUS

TACROLIMUS
TACROLIMUS structure
CAS No.
109581-93-3
Chemical Name:
TACROLIMUS
Synonyms
FK-506;135175;CS-1308;Tacarolimus;[3R[E(1S,3S,4S);tacrolimushydrate;FK-506 MONOHYDRATE;Tacrolimus (150 mg);FR900506 monohydrate;tsukubaenolidehydrate
CBNumber:
CB4772400
Molecular Formula:
C44H69NO12
Formula Weight:
822.04
MOL File:
109581-93-3.mol

TACROLIMUS Properties

Melting point:
127-129°
alpha 
D23 -84.4° (c = 1.02 in chloroform)
storage temp. 
-20°C
solubility 
DMSO: soluble20mg/mL
form 
powder
Merck 
14,9025
InChIKey
NWJQLQGQZSIBAF-MLAUYUEBSA-N
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P310+P330-P301+P310
Hazard Codes  T
Risk Statements  25
Safety Statements  45
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  KD4201200
HazardClass  6.1
PackingGroup  III
HS Code  2934990002
Toxicity LD50 i.p. in mice: >200 mg/kg (Kino); LD50 in male, female rats (mg/kg): 57.0, 23.6 i.v.; 134, 194 orally (Ohara)

TACROLIMUS price More Price(42)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0001926 Tacrolimus monohydrate European Pharmacopoeia (EP) Reference Standard 109581-93-3 $137 2021-12-16 Buy
Sigma-Aldrich F4679 FK-506 monohydrate ≥98% (HPLC) 109581-93-3 5mg $226 2021-12-16 Buy
Sigma-Aldrich 1642802 Tacrolimus United States Pharmacopeia (USP) Reference Standard 109581-93-3 150mg $384 2021-12-16 Buy
TCI Chemical M2258 Tacrolimus Monohydrate >80.0%(HPLC) 109581-93-3 10mg $242 2021-12-16 Buy
TCI Chemical M2258 Tacrolimus Monohydrate >80.0%(HPLC) 109581-93-3 50mg $841 2021-12-16 Buy

TACROLIMUS Chemical Properties,Uses,Production

Uses

immune suppressant, antifungal

Definition

ChEBI: A hydrate that is the monohydrate form of tacrolimus.

Biological Activity

Potent calcineurin (protein phosphatase 2B) inhibitor that requires FK 506-binding protein 12 (FKBP12) for activity (IC 50 = 3 nM). Inhibits secretion of IL-1, IL-2 (IC 50 = 1 nM), IL-3, IL-4, IL-6 (IC 50 = 35 nM), GM-CSF, TNF α (IC 50 = 10 nM), IFN γ and Myc from activated T-cells in vitro . Exhibits potent immunosuppressive, neuroprotective and anticonvulsant activity in vivo .

Safety Profile

A poison by ingestion and intravenous routes. When heated to decomposition it emits toxic vapors of NOx.

TACROLIMUS Preparation Products And Raw materials

Raw materials

Preparation Products


TACROLIMUS Suppliers

Global( 176)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 567 55
Shanxi Naipu Import and Export Co.,Ltd
+8613734021967
kaia@neputrading.com CHINA 1011 58
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29954 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2940 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19752 58
Beijing Yibai Biotechnology Co., Ltd
0086-182-6772-3597
sales04@yibaibiotech.com CHINA 420 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58

View Lastest Price from TACROLIMUS manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2022-01-20 TACROLIMUS
109581-93-3
US $10.00 / KG 10ASSAYS 99% 500kg/month Shanxi Naipu Import and Export Co.,Ltd
2021-09-29 Tacrolimus monohydrate
109581-93-3
US $0.00-0.00 / g 1g 98%-102% 500G WUHAN FORTUNA CHEMICAL CO., LTD
2021-07-13 Tacrolimus Monohydrate CAS 109581-93-3
109581-93-3
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

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