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TACROLIMUS

TACROLIMUS
TACROLIMUS structure
CAS No.
109581-93-3
Chemical Name:
TACROLIMUS
Synonyms
FK-506;Tacarolimus;tacrolimushydrate;FK-506 MONOHYDRATE;Tacrolimus (150 mg);tsukubaenolidehydrate;Tacrolimus monohydrate;FK-506 monohydrate, >=98%;Tacrolimus /FK506 monohydrate;FK506 Monohydrate[Tacrolimus Hydrate]
CBNumber:
CB4772400
Molecular Formula:
C44H69NO12
Formula Weight:
822.04
MOL File:
109581-93-3.mol

TACROLIMUS Properties

Melting point:
127-129°
alpha 
D23 -84.4° (c = 1.02 in chloroform)
storage temp. 
−20°C
solubility 
DMSO: soluble20mg/mL
form 
powder
Merck 
14,9025
InChIKey
NWJQLQGQZSIBAF-MLAUYUEBSA-N
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T
Risk Statements  25
Safety Statements  45
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  KD4201200
HazardClass  6.1
PackingGroup  III
Toxicity LD50 i.p. in mice: >200 mg/kg (Kino); LD50 in male, female rats (mg/kg): 57.0, 23.6 i.v.; 134, 194 orally (Ohara)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
Precautionary statements:
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

TACROLIMUS price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich F4679 FK-506 monohydrate ≥98% (HPLC) 109581-93-3 5mg $210 2018-11-20 Buy
Sigma-Aldrich 1642802 Tacrolimus United States Pharmacopeia (USP) Reference Standard 109581-93-3 150mg $338 2018-11-20 Buy
TCI Chemical M2258 Tacrolimus Monohydrate >80.0%(HPLC) 109581-93-3 10mg $231 2018-11-22 Buy
TCI Chemical M2258 Tacrolimus Monohydrate >80.0%(HPLC) 109581-93-3 50mg $808 2018-11-22 Buy
Sigma-Aldrich PHR1809 Tacrolimus Pharmaceutical Secondary Standard; Certified Reference Material 109581-93-3 150mg $338 2018-11-20 Buy

TACROLIMUS Chemical Properties,Uses,Production

Uses

immune suppressant, antifungal

Definition

ChEBI: A hydrate that is the monohydrate form of tacrolimus.

Biological Activity

Potent calcineurin (protein phosphatase 2B) inhibitor that requires FK 506-binding protein 12 (FKBP12) for activity (IC 50 = 3 nM). Inhibits secretion of IL-1, IL-2 (IC 50 = 1 nM), IL-3, IL-4, IL-6 (IC 50 = 35 nM), GM-CSF, TNF α (IC 50 = 10 nM), IFN γ and Myc from activated T-cells in vitro . Exhibits potent immunosuppressive, neuroprotective and anticonvulsant activity in vivo .

Safety Profile

A poison by ingestion and intravenous routes. When heated to decomposition it emits toxic vapors of NOx.

TACROLIMUS Preparation Products And Raw materials

Raw materials

Preparation Products


TACROLIMUS Suppliers

Global( 101)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3203 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 bruce@xrdchem.cn CHINA 541 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20095 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930501651
breeduan@crovellbio.com CHINA 925 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20516 58
Hebei Chisure Biotechnology Co., Ltd.
+8613292893290
+8613292893290 Nancy@SpeedGainpharma.com CHINA 1020 58
Beijing Mesochem Technology Co., Ltd. 010-57862036-0;13301267296;QQ:2949535984
010-57862036-818 msales@mesochem.com China 294 58
Wuhan Netcom Electronic Commerce Limited 18029749525
0757-88210752 2355935187@ycphar.com China 5134 58
Shanghai Boyle Chemical Co., Ltd.
86-21-57758967 sales@boylechem.com China 2927 55

View Lastest Price from TACROLIMUS manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-17 TACROLIMUS
109581-93-3
US $1.00 / kg 1kg 99.99% Customized career henan chemical co
2018-07-30 TACROLIMUS
109581-93-3
US $10.00 / KG 10G 99% 500kg/month Hebei Chisure Biotechnology Co., Ltd.
2018-03-29 Tacrolimus Monohydrate CAS 109581-93-3
109581-93-3
US $10.00 / KG 10KG 99% 10MT Hubei XinRunde Chemical Co., Ltd.

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