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TSHR antagonist S37

TSHR antagonist S37 structure

CAS No.: 1217616-61-9

Chemical Name:: TSHR antagonist S37

Synonyms: TSHR antagonist S37;TSHR antagonist S37,TSHR antagonist S-37;7,10-Diphenyl-3,4a,5,5a,8a,9,9a,10-octahydro-5,9-methanothiazolo[5',4':5,6]thiopyrano[2,3-f]isoindole-2,6,8(7H)-trione;7,10-Diphenyl-3,4a,5,5a,8a,9,9a,10-octahydro-5,9-methanothiazolo[5',4':5,6]thiopyrano[2,3-f]isoindole-2,6,8(7H)-trione;5,9-Methanothiazolo[5',4':5,6]thiopyrano[2,3-f]isoindole-2,6,8(7H)-trione, 3,4a,5,5a,8a,9,9a,10-octahydro-7,10-diphenyl-

CBNumber:: CB48054566

Molecular Formula:: C25H20N2O3S2

Molecular Weight:: 460.57

MDL Number:

MOL File:: 1217616-61-9.mol

Last updated:2023-09-20 16:43:00

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TSHR antagonist S37 Properties

Density	1.54±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
pka	9.16±0.40(Predicted)

TSHR antagonist S37 Chemical Properties,Uses,Production

Biological Activity

TSHR antagonist S37 is a selective and competitive antagonist of the thyrotropin receptor (TSHR). TSHR antagonist S37 not only inhibits the thyrotropin receptor (TSHR) activation by thyrotropin itself but also activation by monoclonal TSAb M22 (human), KSAb1 (murine), and the allosteric small-molecule agonist C2. Disease-related ex vivo studies in HEK 293 cells expressing the TSHR shows that TSHR antagonist S37 also inhibits cyclic adenosine monophosphate formation by oligoclonal thyroid stimulating antibodies (TSAb).[1] TSHR antagonist S37 has no toxicity and a remarkable 53% oral bioavailability in mice, indicating by initial in vivo pharmacokinetic studies.[1];

References

[1] Neumann S, et al. Eur Thyroid J. 2020 Dec;9(Suppl 1):59-65.

TSHR antagonist S37 Preparation Products And Raw materials

Raw materials

Preparation Products

TSHR antagonist S37 Suppliers

Global( 6)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Tianjin Kailiqi Biotechnology Co., Ltd.	15076683720	klq@cw-bio.com	China	3444	55
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8011	62
Bide Pharmatech Ltd.	400-1647117 15221909166	product02@bidepharm.com	China	61720	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24131	58
Henan Alpha Chemical Co., Ltd.	0371-55013243 15324716602	2853979810@qq.com	China	9755	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Tianjin Kailiqi Biotechnology Co., Ltd.	55
ShangHai Biochempartner Co.,Ltd	62
Bide Pharmatech Ltd.	58
TargetMol Chemicals Inc.	58
Henan Alpha Chemical Co., Ltd.	58

TSHR antagonist S37 Spectrum

TSHR antagonist S37(1217616-61-9)¹HNMR

TSHR antagonist S37 TSHR antagonist S37,TSHR antagonist S-37 5,9-Methanothiazolo[5',4':5,6]thiopyrano[2,3-f]isoindole-2,6,8(7H)-trione, 3,4a,5,5a,8a,9,9a,10-octahydro-7,10-diphenyl- 7,10-Diphenyl-3,4a,5,5a,8a,9,9a,10-octahydro-5,9-methanothiazolo[5',4':5,6]thiopyrano[2,3-f]isoindole-2,6,8(7H)-trione 7,10-Diphenyl-3,4a,5,5a,8a,9,9a,10-octahydro-5,9-methanothiazolo[5',4':5,6]thiopyrano[2,3-f]isoindole-2,6,8(7H)-trione 1217616-61-9