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PROTAC PARP1 degrader

PROTAC PARP1 degrader Structure
PROTAC PARP1 degrader structure
CAS No.
2369022-68-2
Chemical Name:
PROTAC PARP1 degrader
Synonyms
PROTAC PARP1 degrader;2-(4-(1-(1-(4-((4R,5S)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)-2-oxopiperazin-1-yl)-2-oxo-6,9,12,15-tetraoxa-3-azaheptadecan-17-yl)-1H-1,2,3-triazol-4-yl)phenyl)-2H-indazole-7-carboxamide;2H-Indazole-7-carboxamide, 2-[4-[1-[17-[4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-oxo-1-piperazinyl]-16-oxo-3,6,9,12-tetraoxa-15-azaheptadec-1-yl]-1H-1,2,3-triazol-4-yl]phenyl]-
CBNumber:
CB48054607
Molecular Formula:
C58H63Cl2N11O10
Molecular Weight:
1145.09
MDL Number:
MFCD32705102
MOL File:
2369022-68-2.mol
Last updated:2023-05-21 10:59:17
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PROTAC PARP1 degrader Properties

Density 1.39±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
pka 14.32±0.46(Predicted)

PROTAC PARP1 degrader Chemical Properties,Uses,Production

Biological Activity

PROTAC PARP1 degrader is a PARP1 degrader based on MDM2 E3 ligand. It induces significant PARP1 cleavage and programmed cell death. PROTAC PARP1 degrader at 10 μM at 24 h inhibits MDA-MB-231 cell line with an IC50 of 6.12 μM.

References

[1]. Zhao Q, et al. Induction of apoptosis in MDA-MB-231 breast cancer cells by a PARP1-targeting PROTAC small molecule. Chem Commun (Camb). 2019 Jan 2;55(3):369-372.

PROTAC PARP1 degrader Preparation Products And Raw materials

Raw materials

Preparation Products

PROTAC PARP1 degrader Suppliers

Global( 7)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057 3003855609@qq.com China 7892 56
Shanghai Chaolan Chemical Technology Center QQ:65489617 15618227136 info@SuperLan-chem.com China 9748 58
Jilin Province Woda Biotechnology Co., Ltd. 13504435624 1927928688@qq.com China 1294 58
Changzhou Bojia Biomedical Technology Co., Ltd. 2122619822 czbjpharma@126.com China 18488 58
Henan Alpha Chemical Co., Ltd. 0371-55013243 15324716602 2853979810@qq.com China 9879 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 4030 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Sichuan Wei Keqi Biological Technology Co., Ltd. 56
Shanghai Chaolan Chemical Technology Center 58
Jilin Province Woda Biotechnology Co., Ltd. 58
Changzhou Bojia Biomedical Technology Co., Ltd. 58
Henan Alpha Chemical Co., Ltd. 58
Nantong QuanYi Biotechnology Co., Ltd 58

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PROTAC PARP1 degrader 2H-Indazole-7-carboxamide, 2-[4-[1-[17-[4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-oxo-1-piperazinyl]-16-oxo-3,6,9,12-tetraoxa-15-azaheptadec-1-yl]-1H-1,2,3-triazol-4-yl]phenyl]- 2-(4-(1-(1-(4-((4R,5S)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)-2-oxopiperazin-1-yl)-2-oxo-6,9,12,15-tetraoxa-3-azaheptadecan-17-yl)-1H-1,2,3-triazol-4-yl)phenyl)-2H-indazole-7-carboxamide 2369022-68-2