BCN-PEG3-VC-PFP ester
- CAS No.
- 2353409-45-5
- Chemical Name:
- BCN-PEG3-VC-PFP ester
- Synonyms
- BCN-PEG3-VC-PFP ester;endo BCN-PEG3-VC-PFP Ester;L-Ornithine, N-[16-(1R,8S)-bicyclo[6.1.0]non-4-yn-9-yl-1,14-dioxo-4,7,10,15-tetraoxa-13-azahexadec-1-yl]-L-valyl-N5-(aminocarbonyl)-, 2,3,4,5,6-pentafluorophenyl ester
- CBNumber:
- CB48054667
- Molecular Formula:
- C37H50F5N5O10
- Molecular Weight:
- 819.81
- MDL Number:
- MFCD32069533
- MOL File:
- 2353409-45-5.mol
| Product description | Number | Pack Size | Price |
| BCN-PEG3-VC-PFPEster 96% | BP-24334 | 100mg | $840 |
| Boiling point | 925.6±65.0 °C(Predicted) |
|---|---|
| Density | 1.34±0.1 g/cm3(Predicted) |
| solubility | Soluble in DMSO, DCM, DMF |
| pka | 12.05±0.46(Predicted) |
| InChIKey | ODFSIYMVJDIAIS-COWKONOXSA-N |
| SMILES | C(OC1=C(F)C(F)=C(F)C(F)=C1F)(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)CCOCCOCCOCCNC(=O)OCC1[C@@]2([H])[C@]1([H])CCC#CCC2 |
BCN-PEG3-VC-PFP ester Chemical Properties,Uses,Production
Description
BCN-PEG3-VC-PFP Ester is a cleavable ADC linker. PFP ester can be reactive with amine-bearing molecule to form stable amide bond. The Val-Cit will specifically be cleaved by Cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell. The BCN group can react with azide-tagged biomolecules.
Uses
BCN-PEG3-VC-PFP ester is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. BCN-PEG3-VC-PFP ester is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
IC 50
Protease Cleavable Linker; Cleavable Linker
References
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268
BCN-PEG3-VC-PFP ester Preparation Products And Raw materials
Raw materials
Preparation Products
BCN-PEG3-VC-PFP ester Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| Alfa Chemistry | +1-5166625404; | Info@alfa-chemistry.com | United States | 20405 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42056 | 58 |
| Xian confluore Biological Technology Co., Ltd. | +86-15680926068 | 1924344760@confluore.cn | China | 2997 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19961 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12306 | 58 |
| Xi'an Confluore Biological Technology Co., Ltd. | +86-156-80926068 +86-15680926068 | 1924344760@qq.com | China | 4952 | 58 |
| Abydos Scientific | 025-84767922 18936879710 | sales@abydoscientific.com | China | 1002 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85563444 18351873721 | purchase@synzest.com | China | 10434 | 58 |
View Lastest Price from BCN-PEG3-VC-PFP ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-10-27 | BCN-PEG3-VC-PFP ester
2353409-45-5
|
US $223.00-737.00 / mg | 10g | TargetMol Chemicals Inc. | |||
 |
2025-06-07 | endo BCN-PEG3-VC-PFP Ester
2353409-45-5
|
US $0.00 / mg | 100mg | >95.00% | 100mg | Xian confluore Biological Technology Co., Ltd. |
-
- BCN-PEG3-VC-PFP ester
2353409-45-5
- US $223.00-737.00 / mg
- TargetMol Chemicals Inc.
-
- endo BCN-PEG3-VC-PFP Ester
2353409-45-5
- US $0.00 / mg
- >95.00%
- Xian confluore Biological Technology Co., Ltd.
