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BENZOIC ACID, 2-[[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]AMINO]-3-NITRO-METHYL ESTER

BENZOIC ACID, 2-[[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]AMINO]-3-NITRO-METHYL ESTER structure

CAS No.: 139481-28-0

Chemical Name:: BENZOIC ACID, 2-[[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]AMINO]-3-NITRO-METHYL ESTER

Synonyms: methyl 2-((2'-cyanobiphenyl-4-yl)methylamino)-3-nitrobenzoate;Candesartan Cilexetil Impurity 8;Candesartan Cilexetil Impurity 24;4-yl)methyl]amino]-3-nitro-,methyl ester;Benzoic acid, 2-[[(2'-cyano[1,1'-biphenyl]-;CANDESARTAN INTERMEDIATES ( METHYL ESTER C4 );BENZOIC ACID, 2-[[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]AMINO...;methyl 2-[[4-(2-cyanophenyl)phenyl]methylamino]-3-nitrobenzoate;Methyl,2-[[(2'-Cyano[1,1'-Biphenyl]-4-yl)methyl]amino]-3-Nitro Benzoate;Methyl 2-(((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)amino)-3-nitrobenzoate

CBNumber:: CB4840451

Molecular Formula:: C22H17N3O4

Molecular Weight:: 387.39

MDL Number:: MFCD09029084

MOL File:: 139481-28-0.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:44

Product description	Number	Pack Size	Price
2-[[(2''-Cyano[1,1''-biphenyl]-4-yl)methyl]amino]-3-nitro-benzoicAcidMethylEster	C988320	100mg	$1110
BENZOICACID, 2-(((2'-CYANO(1,1'-BIPHENYL)-4-YL)METHYL)AMINO)-3-NITRO-METHYLESTER 95.00%	CHM0151564	100MG	$1871.1
2-[[(2??-Cyano[1,1??-biphenyl]-4-yl)methyl]amino]-3-nitro-benzoicAcidMethylEster	56190	100mg	$2120
Methyl-2-[[(2'-cyanobiphenyl-4-yl)methyl]amino]-3-nitrobenzoate	Y6572	100mg	$88
Methyl-2-[[(2'-cyanobiphenyl-4-yl)methyl]amino]-3-nitrobenzoate	Y6572	1g	$162
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BENZOIC ACID, 2-[[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]AMINO]-3-NITRO-METHYL ESTER Properties

Melting point	133-135°C
Boiling point	595.5±50.0 °C(Predicted)
Density	1.33±0.1 g/cm3 (20 ºC 760 Torr)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
form	Solid
pka	-2.55±0.10(Predicted)
color	Off-White to Light Yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

BENZOIC ACID, 2-[[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]AMINO]-3-NITRO-METHYL ESTER price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	C988320	2-[[(2''-Cyano[1,1''-biphenyl]-4-yl)methyl]amino]-3-nitro-benzoicAcidMethylEster	139481-28-0	100mg	$1110	2021-12-16	Buy
American Custom Chemicals Corporation	CHM0151564	BENZOICACID, 2-(((2'-CYANO(1,1'-BIPHENYL)-4-YL)METHYL)AMINO)-3-NITRO-METHYLESTER 95.00%	139481-28-0	100MG	$1871.1	2021-12-16	Buy
Medical Isotopes, Inc.	56190	2-[[(2??-Cyano[1,1??-biphenyl]-4-yl)methyl]amino]-3-nitro-benzoicAcidMethylEster	139481-28-0	100mg	$2120	2021-12-16	Buy
AK Scientific	Y6572	Methyl-2-[[(2'-cyanobiphenyl-4-yl)methyl]amino]-3-nitrobenzoate	139481-28-0	100mg	$88	2021-12-16	Buy
AK Scientific	Y6572	Methyl-2-[[(2'-cyanobiphenyl-4-yl)methyl]amino]-3-nitrobenzoate	139481-28-0	1g	$162	2021-12-16	Buy

Product number	Packaging	Price	Buy
C988320	100mg	$1110	Buy
CHM0151564	100MG	$1871.1	Buy
56190	100mg	$2120	Buy
Y6572	100mg	$88	Buy
Y6572	1g	$162	Buy

BENZOIC ACID, 2-[[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]AMINO]-3-NITRO-METHYL ESTER Chemical Properties,Uses,Production

Chemical Properties

Yellow Solid

Uses

Intermediate in the synthesis of nonpeptide angiotensin II receptor antagonists. Candesartan (C175575) impurity. Candesartan Cilexetil (C175580) impurity.

Synthesis

Methyl 2-[N-(tert-Butoxycarbonyl)-N-[(2'-cyanobiphenyl-4-yl)Methyl]aMino]-3-nitrobenzoate

139481-38-2

BENZOIC ACID, 2-[[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]AMINO]-3-NITRO-METHYL ESTER

139481-28-0

30.1 g of methyl 2-((tert-butoxycarbonyl)((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)amino)-3-nitrobenzoate [BAN], 40.8 g of potassium carbonate, and 160 ml of acetonitrile were mixed, and the reaction system may have contained unreacted 2-(4-methylphenyl)benzylcarbonitrile [MPB] and, as a by-product, 2-(4,4-dibromomethylphenyl) benzyl cyanide. The reaction was stirred at 82°C for 5 hours. After completion of the reaction, it was cooled to room temperature, the precipitated crystals were collected by filtration and the filtrate was concentrated to give methyl 2-[N-tert-butoxycarbonyl-N-[(2'-cyanobiphenyl-4-yl)methyl]amino]-3-nitrobenzoate [BBN]. The concentrate was dissolved in 190 g of methanol and 106 g of concentrated hydrochloric acid was added slowly and dropwise. The reaction solution was heated to reflux temperature and kept at reflux stirring for 2 hours. After cooling, the precipitated crystals were collected by filtration and dropwise addition to give 35.1 g of methyl 2-[N-(2'-cyanobiphenyl-4-yl)methylamino]-3-nitrobenzoate [MBN] in 76.1% yield (based on 2-(4-methylphenyl)benzonitrile [MPB]). In Reference Example 4 (2), the resulting concentrate (BBN) was mixed with 3200 L of methanol at 30°C or lower and 1050 L of 35% concentrated hydrochloric acid was added over about 4 hours. The mixture was heated to reflux temperature (67-69°C) at a rate not exceeding 10°C/hour and stirred at reflux for about 1.5 hours. The reaction solution was cooled, 800 L of methanol was added and stirred at 3 to 10 °C for about 1 hour. The precipitated crystals were separated, washed with methanol and dried to give 407 kg of methyl 2-[[(2'-cyanobiphenyl-4-yl)methyl]amino]-3-nitrobenzoate [MBN] in 75% yield (based on MPB). Melting point: 140 to 141 °C. 1H-NMR (200 MHz, DMSO-d6) δ: 3.84 (3H, s), 4.26 (2H, m), 6.86 (1H, t), 7.46 (2H, d), 7.54-7.65 (4H, m), 7.79 (1H, d), 7.95 (1H, dd), 8.05-8.11 ( 2H, m), 8.67 (1H, t).

References

[1] Journal of Medicinal Chemistry, 1993, vol. 36, # 15, p. 2182 - 2195
[2] Patent: EP1420016, 2004, A1. Location in patent: Page 16-17; 18

BENZOIC ACID, 2-[[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]AMINO]-3-NITRO-METHYL ESTER Preparation Products And Raw materials

Raw materials

Methyl 2-[N-(tert-Butoxycarbonyl)-N-[(2'-cyanobiphenyl-4-yl)Methyl]aMino]-3-nitrobenzoate Methanol Water Hydrochloric acid

Preparation Products

Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate Ethyl-3-Amino-2-[(2'-Cyanoiphenyl-4-yl) Methyl]-Amino Benzoate

BENZOIC ACID, 2-[[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]AMINO]-3-NITRO-METHYL ESTER Suppliers

Global( 130)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Worldyang Chemical Co.,Ltd.	+86-021-56795779 +8613651600618	sales@worldyachem.com	China	967	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29795	58
Univar Solutions(China) Co., Ltd.	+8615902132654	ivy.zhuang@univarsolutions.com	China	654	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-0519-85551759 +8613506123987	marketing1@neostarunited.com	China	8830	58
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	sales@myuchem.com	China	8566	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15086	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52846	58
Hangzhou Benoy Chemical Co., Ltd	+8617342059697	sales@benoychem.com	China	315	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418684 +8618949823763	sales@tnjchem.com	China	25356	58
PNP Biotech Co. Ltd	+8618516098983	sales@pnpbiotech.com	China	1001	58

Supplier	Advantage
Shanghai Worldyang Chemical Co.,Ltd.	58
career henan chemical co	58
Univar Solutions(China) Co., Ltd.	58
Neostar United (Changzhou) Industrial Co., Ltd.	58
Shanghai UCHEM Inc.	58
AFINE CHEMICALS LIMITED	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Hangzhou Benoy Chemical Co., Ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
PNP Biotech Co. Ltd	58

View Lastest Price from BENZOIC ACID, 2-[[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]AMINO]-3-NITRO-METHYL ESTER manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-03-28	Methyl2-((2'-cyanobiphenyl-4-yl)methylamino)-3-nitrobenzoate 139481-28-0	US $0.00 / KG	25KG	98%-99%	Inquiry	PNP Biotech Co. Ltd
	2020-01-05	BENZOIC ACID, 2-[[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]AMINO]-3-NITRO-METHYL ESTER 139481-28-0	US $7.00 / KG	1KG	99%	100KG	Career Henan Chemical Co

Methyl2-((2'-cyanobiphenyl-4-yl)methylamino)-3-nitrobenzoate
139481-28-0
US $0.00 / KG
98%-99%
PNP Biotech Co. Ltd

BENZOIC ACID, 2-[[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]AMINO]-3-NITRO-METHYL ESTER
139481-28-0
US $7.00 / KG
99%
Career Henan Chemical Co

139481-28-0(BENZOIC ACID, 2-[[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]AMINO]-3-NITRO-METHYL ESTER)Related Search:

2-[[(2'-Cyano[1,1'-biphenyl]-4-yl)methyl]amino]-3-nitro-benzoic acid ethyl ester Methyl 3-aMino-2-((2'-carbaMoylbiphenyl-4-yl)MethylaMino)benzoate Azilsartan Medoxomil (Z)-2-ethoxy-3-((2'-(N'-hydroxycarbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d]iMidazole-4-carboxylic acid (Z)-Methyl 3-((2'-(N'-hydroxycarbaMiMidoyl)biphenyl-4-yl)Methyl)-2-oxo-2,3-dihydro-1H-benzo[d]iMidazole-4-carboxylate

Azilsartan iMpurity I Methyl 2-oxo-3-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)Methyl)-2,3-dihydro-1H-benzo[d]iMidazole-4-carboxylate Ethyl-2-Ethoxy-1-[[(2'-Cyanobiphenyl-4-yl) Methyl] Benzimidazole]-7-Carboxylate BENZOIC ACID, 2-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]-3-NITRO-METHYL ESTER Methyl 2-ethoxybenzimidazole-7-carboxylate

Ethyl -2-ethoxy-1-[[(2-(1Htetrazol-5-yl)biphenyl-4-yl-) methyl] 2-[1.1-dimethyl ethyl ethoxy carbonyl]amino-3-nitro benzoic acid ethyl ester Ethyl-3-Amino-2-[(2'-Cyanoiphenyl-4-yl) Methyl]-Amino Benzoate Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate Methyl 2,3-diaminobenzoate

Methyl 2-amino-3-nitrobenzoate 4'-(aminomethyl)biphenyl-2-carbonitrile BENZOIC ACID, 2-[[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]AMINO]-3-NITRO-METHYL ESTER

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BENZOIC ACID, 2-[[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]AMINO]-3-NITRO-METHYL ESTER Methyl,2-[[(2'-Cyano[1,1'-Biphenyl]-4-yl)methyl]amino]-3-Nitro Benzoate 4-yl)methyl]amino]-3-nitro-,methyl ester Benzoic acid, 2-[[(2'-cyano[1,1'-biphenyl]- Candesartan Cilexetil Impurity 8 CANDESARTAN INTERMEDIATES ( METHYL ESTER C4 ) BENZOIC ACID, 2-[[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]AMINO... methyl 2-((2'-cyanobiphenyl-4-yl)methylamino)-3-nitrobenzoate Candesartan Cilexetil Impurity 24 Methyl 2- ((2 '- cyanobiphenyl-4-yl) methylamino) -3-nitrobenzoate methyl ester Methyl 2-(((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)amino)-3-nitrobenzoate 2-[[(2'-Cyano[1,1'-biphenyl]-4-yl)methyl]amino]-3-nitro-benzoic acid methyl ester Methyl 2-(((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)amino)-3-nitrobenzoate (Candesartan Impurity) methyl 2-[[4-(2-cyanophenyl)phenyl]methylamino]-3-nitrobenzoate Methyl 2-(((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)amino)-3-nitrobenzoate (Candesartan Impurity) 2-[[(2'-Cyano[1,1'-biphenyl]-4-yl)methyl]amino]-3-nitro-benzoic Acid Methyl Ester 139481-28-0 139481-28-9 Aromatics Intermediates & Fine Chemicals Pharmaceuticals