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Cilomilast

Cilomilast
Cilomilast structure
CAS No.
153259-65-5
Chemical Name:
Cilomilast
Synonyms
CS-515;Ariflo;ArifloR;Clomilast;SB 207499;Cilomelast;CILOMILAST;Cilomilast USP/EP/BP;Sb207499 Cilomilast;CiloMilast(SB-207499)
CBNumber:
CB4841029
Molecular Formula:
C20H25NO4
Formula Weight:
343.42
MOL File:
153259-65-5.mol

Cilomilast Properties

Melting point:
157°C
Boiling point:
549.1±50.0 °C(Predicted)
Density 
1.21±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: soluble15mg/mL, clear
form 
powder
pka
4.45±0.25(Predicted)
color 
white to beige
InChIKey
CFBUZOUXXHZCFB-OYOVHJISSA-N
FDA UNII
8ATB1C1R6X
SAFETY
  • Risk and Safety Statements
WGK Germany  3

Cilomilast price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0733 Cilomilast ≥95% (HPLC) 153259-65-5 5mg $151 2021-03-22 Buy
Sigma-Aldrich SML0733 Cilomilast ≥95% (HPLC) 153259-65-5 25mg $608 2021-03-22 Buy
Cayman Chemical 25979 Cilomilast 153259-65-5 10mg $200 2021-03-22 Buy
Cayman Chemical 25979 Cilomilast 153259-65-5 1mg $25 2021-03-22 Buy
Cayman Chemical 25979 Cilomilast 153259-65-5 5mg $106 2021-03-22 Buy

Cilomilast Chemical Properties,Uses,Production

Chemical Properties

Cilomilast is White Solid

Uses

Cilomilast is a selective phosphodiesterase 4 (PDE4) inhibitor and can be used in treatment of chronic obstructive pulmonary disease.

Mechanism of action

Cilomilast contains the dialkoxyphenyl ring characteristic of selective PDE4 inhibitors. The ether oxygens hydrogen bond to a glutamine in the binding pocket, and the cyclopentyl ring adds additional hydrophobic interactions. The oxygen atoms of the carboxyl group form hydrogen bonds with water that is coordinated with Mg2+ located in the distal end of the binding pocket. Orally administered cilomilast is 96% bioavailable. Food does not interfere with the overall absorption; however, food does slow down the rate. Cilomilast is 99% bound to albumin in the plasma and is metabolized in the liver by CYP2C8. The metabolism is extensive and results in oxidation, carboxyl group glucuronidation, and dealkylation of the cyclopentyl group, followed by glucuronidation or sulfation.

Pharmacokinetics

Cilomilast is rapidly absorbed following oral administration (96% bioavailability), has an elimination half-life of 7 hours, and is extensively metabolized, but not by cytochrom P450 enzymes. The drug shows considerably more selectivity than roflumilast toward PDE4D, and this might account for the common side effects of nausea and emesis. Studies regarding the benefits of cilomilast versus placebo in the treatment of asthma have not been very encouraging, but significant improvement was seen in clinical trials of cilomilast in the treatment of COPD. The side effects of diarrhea and nausea have been considerably higher with cilomilast versus placebo, but these effects generally are tolerable and self limiting.

Cilomilast Preparation Products And Raw materials

Raw materials

Preparation Products


Cilomilast Suppliers

Global( 87)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19753 58
HENAN BON INDUSTRIAL CO.,LTD
0371-55170695
info@hnbon.com CHINA 26742 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47496 58
career henan chemical co
13203830695 0086-371-86658258
0086-371-86658258 factory@coreychem.com CHINA 29865 58
Shaanxi Dideu Medichem Co. Ltd
13772537765
029-88380327 1010@dideu.com CHINA 3993 58
Zhuozhou Wenxi import and Export Co., Ltd
+8613111626072 (WhatsApp)
Wechat: +8613111626072 Wickr me: waynehu zzwenxi@126.com CHINA 13187 58
Target Molecule Corp
18019718960 781-999-5354
marketing@targetmol.com United States 19232 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
13588875226 86-571-88216897、88216896
86-571-88216895 sales@hzclap.com CHINA 6469 58
Dideu Industries Group Limited
029-88380327
Service@dideu.com CHINA 29991 58

View Lastest Price from Cilomilast manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-07-20 Cilomilast
153259-65-5
US $0.00-0.00 / KG 5mg 99% HPLC 2000tons Shaanxi Dideu Medichem Co. Ltd
2021-07-13 Cilomilast
153259-65-5
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2021-07-10 Cilomilast
153259-65-5
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

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