ChemicalBook
Chinese Japanese Germany Korea

Febuxostat

Indications and Usage Mechanisms of Action
Febuxostat
Febuxostat structure
CAS No.
144060-53-7
Chemical Name:
Febuxostat
Synonyms
FBX;Uloric;TMX 67;CS-1598;Tei-6720;Febuxosta;FEBUXOSTAT;FEBUXOSTAT API;Febuxostat IMP;Febuxostat, >=99%
CBNumber:
CB4841564
Molecular Formula:
C16H16N2O3S
Formula Weight:
316.37
MOL File:
144060-53-7.mol

Febuxostat Properties

Melting point:
238-239°(dec.)
Boiling point:
536.6±60.0 °C(Predicted)
Density 
1.31±0.1 g/cm3(Predicted)
storage temp. 
Refrigerator
form 
powder
pka
2.48±0.10(Predicted)
Merck 
14,3948
CAS DataBase Reference
144060-53-7(CAS DataBase Reference)
FDA UNII
101V0R1N2E
SAFETY
  • Risk and Safety Statements
RTECS  XJ3675310

Febuxostat price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical F0847 Febuxostat >97.0%(HPLC)(T) 144060-53-7 1g $82 2020-06-24 Buy
TCI Chemical F0847 Febuxostat >97.0%(HPLC)(T) 144060-53-7 5g $265 2020-06-24 Buy
Cayman Chemical 14127 Febuxostat ≥98% 144060-53-7 10mg $86 2020-06-24 Buy
Cayman Chemical 14127 Febuxostat ≥98% 144060-53-7 5mg $45 2020-06-24 Buy
Cayman Chemical 14127 Febuxostat ≥98% 144060-53-7 25mg $203 2020-06-24 Buy

Febuxostat Chemical Properties,Uses,Production

Indications and Usage

Febuxostat is a new generation xanthine oxidase inhibitor developed by Tejin Co. (Japan,) used clinically for for long-term treatment of hyperuicemia (gout,) a new and highly effective non-purine selective inhibitor of xanthine oxidase. It is not recommended for gout patients without hyperuricemia.

Mechanisms of Action

The production of uric acid in the body is related to purine metabolism. In the last step of the production, hypoxanthine produces xanthine through the action of xanthine oxidoreductase (XOR), finally producing uric acid. Inhibiting the activity of this enzyme can effectively reduce the production of uric acid. Xanthine oxidase is the main enzyme promoting uric acid production. Through highly selective inhibition of oxidized and reduced xanthine oxidase, Febuxostat can reduce synthesis of uric acid, decreasing its concentration and effectively treating gout . Through liver metabolism, Xanthine oxidase does not rely on renal excretion, so patients with moderate to severe liver and kidney dysfunction do not need to reduce dosages. Febuxostat is a non-purine XOR inhibitor, so it is very safe.

Description

Febuxostat, a selective xanthine oxidase inhibitor, was launched for the chronic management of hyperuricemia in patients with gout. Hyperuricemia is defined as a serum uric acid concentration exceeding the limit of solubility. It predisposes affected persons to gout, a disease characterized by the formation of crystals of monosodium urate or uric acid from supersaturated fluids in joints and other tissues. Crystal deposition is asymptomatic, but it is revealed by bouts of joint inflammation. If left untreated, further crystals accumulate in joints and can form deposits known as tophi. A major aim in gout management is the long-term reduction of serum uric acid concentrations below saturation levels, as this results in crystal dissolution and eventual disappearance.
Febuxostat is a nonpurine derivative with higher potency and selectivity than allopurinol for inhibiting xanthine oxidase. It completely inhibits human xanthine oxidase activity in the lung cancer cell line A549, whereas the activities of other enzymes involved in purine or pyrimidine metabolism (e.g., purine nucleoside phosphorylase, adenosine deaminase, and pyrimidine nucleoside phosphorylase) are affected by <4%.
The incidence of adverse events such as dizziness, diarrhea, headache, and nausea with febuxostat was similar to allopurinol. Febuxostat is contraindicated in patients being treated with the xanthine oxidase substrates such as azathioprine, mercaptopurine, and theophylline. Febuxostat can be synthesized in a multistep sequence from 2,4-dicyanophenol, starting with the alkylation of the phenolic hydroxyl group with isobutyl bromide and potassium carbonate, followed by treatment with thioacetamide in hot dimethyl formamide to yield 3-cyano-4-isobutoxythiobenzamide. Cyclization of the thioamide group with 2-chloroacetoacetic acid ethyl ester in refluxing ethanol affords 2-(3-cyano-4-isoutoxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester, which is hydrolyzed with sodium hydroxide to produce febuxostat.

Chemical Properties

Crystalline Solid

Originator

Teijin (Japan)

Uses

antihyperlipidemic

Uses

Xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.

Uses

Febuxostat is primarily indicated in conditions like Gout, Hyperuricemia

brand name

Uloric, Adenuric

Febuxostat Preparation Products And Raw materials

Raw materials

Preparation Products


Febuxostat Suppliers

Global( 412)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21838 58
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22625 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1365 55
PI & PI BIOTECH INC.
18371201331
020-81716319 Sales@pipitech.com CHINA 3048 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24754 60
Hebei Minshang Biotechnology Co., Ltd
+86-13582176207 +86-13582176207
cathy@hbminshang.cn CHINA 312 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30043 58
Zhejiang ZETian Fine Chemicals Co. LTD
+86-18957127338
QQ:800182836 stella@zetchem.com CHINA 2886 58

View Lastest Price from Febuxostat manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-07-07 Febuxostat
144060-53-7
US $600.00 / Kg/Drum 1KG 99% 1000tons/month Hebei Yanxi Chemical Co., Ltd.
2020-07-10 Febuxostat
682-158-6
1ASSAYS 99%min 20Ton Hebei Xibaijie Biotechnology Co., Ltd.
2020-04-30 Febuxostat
144060-53-7
US $1.00-1.00 / Kg/Drum 1g 99% 50tons Shaanxi Dideu Medichem Co. Ltd

144060-53-7(Febuxostat)Related Search:


Copyright 2017 © ChemicalBook. All rights reserved