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1-Nitropropane structure
Chemical Name:
1-NP;n-C3H7NO2;ai3-02264;1-Nitropro;1-Nitropan;NiPar S-10;1-nitro-propan;1-NITROPROPANE;N-Nitropropane;Propane,1-nitro-
Molecular Formula:
Formula Weight:
MOL File:

1-Nitropropane Properties

Melting point:
-108 °C
Boiling point:
132 °C
0.998 g/mL at 25 °C(lit.)
vapor density 
3.1 (vs air)
vapor pressure 
7.5 mm Hg ( 20 °C)
refractive index 
n20/D 1.401(lit.)
Flash point:
93 °F
storage temp. 
Flammables area
pK1:8.98 (25°C)
6.0 (0.9g/l, H2O, 20℃)
explosive limit
Water Solubility 
1.40 g/100 mL
Henry's Law Constant
6.11 at 25 °C (static headspace-GC, Welke et al., 1998)
Exposure limits
NIOSH REL: TWA 25 ppm (90 mg/m3), IDLH 1,000 ppm; OSHA PEL: TWA 25 ppm; ACGIH TLV: TWA 25 ppm (adopted).
Stable. Flammable. Incompatible with strong bases, strong oxidizing agents.
CAS DataBase Reference
108-03-2(CAS DataBase Reference)
NIST Chemistry Reference
Propane, 1-nitro-(108-03-2)
EPA Substance Registry System
Propane, 1-nitro-(108-03-2)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
  • NFPA
Hazard Codes  Xn
Risk Statements  10-20/21/22
Safety Statements  9-24/25
RIDADR  UN 2608 3/PG 3
WGK Germany  1
RTECS  TZ5075000
Autoignition Temperature 788 °F
HazardClass  3
PackingGroup  III
HS Code  29042000
Hazardous Substances Data 108-03-2(Hazardous Substances Data)
Toxicity LD50 orally in Rabbit: 455 mg/kg LD50 dermal Rabbit > 2000 mg/kg
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H226 Flammable liquid and vapour Flammable liquids Category 3 Warning
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning P280,P302+P352, P312, P322, P363,P501
H331 Toxic if inhaled Acute toxicity,inhalation Category 3 Danger P261, P271, P304+P340, P311, P321,P403+P233, P405, P501
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning P261, P271, P304+P340, P312
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P311 Call a POISON CENTER or doctor/physician.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

NFPA 704

Diamond Hazard Value Description
2 2
Health   2 Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury (e.g. diethyl ether, ammonium phosphate, iodine)
Flammability   3 Liquids and solids (including finely divided suspended solids) that can be ignited under almost all ambient temperature conditions . Liquids having a flash point below 22.8 °C (73 °F) and having a boiling point at or above 37.8 °C (100 °F) or having a flash point between 22.8 and 37.8 °C (73 and 100 °F). (e.g. gasoline, acetone)
Instability   2 Undergoes violent chemical change at elevated temperatures and pressures, reacts violently with water, or may form explosive mixtures with water (e.g. white phosphorus, potassium, sodium)

(NFPA, 2010)

1-Nitropropane price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich N22851 1-Nitropropane ≥98.5% 108-03-2 100ml $23.5 2018-11-13 Buy
Sigma-Aldrich 73788 1-Nitropropane analytical standard 108-03-2 1ml $35.8 2018-11-13 Buy
TCI Chemical N0248 1-Nitropropane >98.0%(GC) 108-03-2 25g $15 2018-11-22 Buy
TCI Chemical N0248 1-Nitropropane >98.0%(GC) 108-03-2 500g $51 2018-11-22 Buy
Alfa Aesar A11975 1-Nitropropane, 98% 108-03-2 500g $59.1 2018-11-13 Buy

1-Nitropropane Chemical Properties,Uses,Production

Chemical Properties

Colorless liquid.Soluble in water 1.4 mL/100 mL (20C); solubility of water in 1-nitropropane 0.5 cc/100 cc (20C).

Chemical Properties

1-Nitropropane is a colorless liquid with a mild, fruity odor.

Physical properties

Colorless, oily liquid with a mild, fruity odor. A detection odor threshold concentration of 510 mg/m3 (140 ppmv) was experimentally determined by Dravnieks (1974).


Solvent, chemical synthesis, rocket propellant, gasoline additive.

Production Methods

1-Nitropropane is produced by vapor-phase nitration of propane with nitric acid (Baker and Bollmeier 1978) or by the vapor-phase nitration of butanol (HSDB 1988).


Flammable, moderate fire risk, moderate explosion hazard when shocked or heated. Liver damage, eye and upper respiratory tract irritant. Questionable carcinogen.

Health Hazard

Humans exposed briefly to vapors of 1-nitropropane were found to have concentrations exceeding 100 p.p.m. irritating to the eyes (HSDB 1988). The chemical may produce anorexia, nausea, vomiting, diarrhea as well as injury to the liver and kidneys in exposed humans. High concentrations of the chemical also may produce methemoglobinemia with cyanosis. 1-Nitropropane vapors also are damaging to the lungs. 1-Nitropropane is, however, more acutely irritating to mucus membranes than 2-nitropropane. Despite this, the TLV for human exposure to 2-nitropropane is less than that for 1-nitropropane, based on the carcinogenic potential of 2-nitropropane in rats.

Industrial uses

1-Nitropropane is used as a solvent for cellulose acetate, vinyl resins and lacquers. It is also used as a gasoline additive (HSDB 1988).

Safety Profile

Poison by ingestion and intraperitoneal routes. Mildly toxic by inhalation. A human eye irritant. Human systemic effects by inhalation: conjunctiva irritation. Mutation data reported. Very dangerous fire hazard when exposed to heat, open flame, or oxidizers. Reacts violently with Ca(OH)2, hydrocarbons, hydroxides, inorganic bases. May explode on heating. Metal oxides increase its sensitivity to thermal ignition. To fight fire, use alcohol foam, CO2, dry chemical, water spray. When heated to decomposition it emits toxic fumes of NOx. See also 2- NITROPROPANE, NITROALKANES, and NITRO COMPOUNDS.

Potential Exposure

1-Nitropropane is used as a solvent for polymers, as a stabilizer; and in organic synthesis. Note: Technical products measurably contaminated with 2-Nitropropane, see also 2-Nitropropane (N: 0550)


1-Nitropropane is a substrate for the liver microsomal cytochrome P-450-dependent mixed-function oxidase system. Oxidative denitrification of 1-nitropropane by phenobarbital-induced rat microsomes occurred at a rate of 0.6 nmole/min/mg protein. This rate was much slower than for 2-nitropropane which was metabolized at 2.4 nmole/min/mg microsomal protein (Ullrich et al 1978).
The role of the cytochrome P-450 system in vivo in 1-nitropropane metabolism is unknown. Bray and James (1958) isolated a small amount of a mercapturic acid metabolite from the urine of rabbits dosed with 1-nitropropane.


UN2608 Nitropropanes, Hazard Class: 3; Labels: 3-Flammable liquid.

Purification Methods

Purify it as for nitromethane. [Beilstein 1 IV 229.]


1-Nitropropane, a nitroparaffinin, forms exposive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, reducing agents; nitrates, amines, hydrocarbons, and other combustible materials; metal oxides. May explode on heating.

1-Nitropropane Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Nitropropane Spectrum

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