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Chloroacetic anhydride

Chloroacetic anhydride Structure
Chloroacetic anhydride structure
CAS No.
541-88-8
Chemical Name:
Chloroacetic anhydride
Synonyms
2-Chloroacetic anhydride;Monochloroacetic anhydride;CHLOROACETIC ACID ANHYDRIDE;MONOCHLOROACETIC ACID ANHYDRIDE;NSC 71207;oroacetic anhydride;chloraceticanhydride;Chloracetic anhydride;chloroacetylanhydride;CHLOROACETIC ANHYDRIDE
CBNumber:
CB4853783
Molecular Formula:
C4H4Cl2O3
Molecular Weight:
170.97
MDL Number:
MFCD00000929
MOL File:
541-88-8.mol
MSDS File:
SDS
Last updated:2023-08-23 18:01:39
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Chloroacetic anhydride Properties

Melting point 51 °C
Boiling point 203 °C
Density 1.449
vapor pressure <0.75 mm Hg ( 20 °C)
refractive index 1.4730 (estimate)
Flash point >230 °F
storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility Freely soluble in ether, chloroform. Slightly soluble in benzene. Insoluble in cold ligroin
form Crystals, Chunks or Low Melting Mass
color brown
Sensitive Moisture Sensitive
Merck 14,2113
BRN 774533
Stability Moisture Sensitive
InChIKey PNVPNXKRAUBJGW-UHFFFAOYSA-N
CAS DataBase Reference 541-88-8(CAS DataBase Reference)
FDA UNII 8Q7TXH7R5F
EPA Substance Registry System Acetic acid, chloro-, anhydride (541-88-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS05,GHS06
Signal word  Danger
Hazard statements  H301-H314
Precautionary statements  P260-P270-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
Hazard Codes  C,T
Risk Statements  34-36/37-43-25
Safety Statements  26-28-36/37/39-45-27
RIDADR  UN 3261 8/PG 2
WGK Germany  3
F  10-19-21
Hazard Note  Highly Toxic/Corrosive/Lachrymator
TSCA  Yes
HazardClass  8
PackingGroup  II
HS Code  29159000
NFPA 704
0
0 0
W

Chloroacetic anhydride price More Price(22)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 215163 Chloroacetic anhydride 95% 541-88-8 25g $216 2024-03-01 Buy
Sigma-Aldrich 215163 Chloroacetic anhydride 95% 541-88-8 100g $352 2024-03-01 Buy
Alfa Aesar A14015 Chloroacetic anhydride, 97% 541-88-8 25g $52.5 2024-03-01 Buy
Alfa Aesar A14015 Chloroacetic anhydride, 97% 541-88-8 100g $106 2024-03-01 Buy
Alfa Aesar A14015 Chloroacetic anhydride, 97% 541-88-8 500g $375.65 2024-03-01 Buy
Product number Packaging Price Buy
215163 25g $216 Buy
215163 100g $352 Buy
A14015 25g $52.5 Buy
A14015 100g $106 Buy
A14015 500g $375.65 Buy

Chloroacetic anhydride Chemical Properties,Uses,Production

Chemical Properties

brownish semi-transparent crystals, chunks or low

Uses

Chloroacetic anhydride has been used in the synthesis of 3,3-bis(sulfonato)-4,4-bis(chloroacetamido)azobenzene (BSBCA), a water-soluble, thiol-reactive and photo-switchable cross-linker, D,L-7-azatryptophan, 2-methyl-[3,4-di-O-acetyl-6-O-(chloroacetyl)-1,2-dideoxy-α-D-glucopyrano]-[2,1:4,5]-2-oxazoline.

Uses

In N-acetylation of amino acids in alkaline solution; preparation of cellulose chloroacetates.

Preparation

chloroacetic anhydride Synthesis: Powdered s odium monochloroacetate(113.3g, 1.138 mol) was added slowly for a period of 15 min at room temperature (which slowly raises to 60°C) to a stirred solution of commercially available chloroaceyl chloride (127.5g, 1mol) in dry benzene (136mL) was refluxed for 9h. Salts were filtered off, the filtrate was cooled to room temperature, diluted with n-hexane and further cooled to 0°C. The solid separated was then filtered, washed with dry hexane and dried to yield chloroacetic anhydride as white crystalline compound in 60% yield (80g); mp=46-49°C [Lit. mp=46°C]. Alternatively, the benzene layer was directly subjected to high vacuum distillation.The product collected at 109-10°C at 10mm vacuum on cooling chloroacetic anhydride in lump form in 70 % yield (93g). It was observed that, the latter method gives anhydride in lump form while the former method gives in crystalline form.

Purification Methods

Crystallise the it from *benzene. [Eglinton et al. J Chem Soc 1860 1954, Beilstein 2 IV 487.]

Chloroacetic anhydride synthesis

3926-62-3
79-04-9
541-88-8
Synthesis of Chloroacetic anhydride from Sodium chloroacetate and Chloroacetyl chloride

Chloroacetic anhydride Preparation Products And Raw materials

Raw materials

Acetic acid, 2-chloro-, anhydride with silicic acid (H4SiO4) (4:1) Chloroacetyl chloride

Preparation Products

D(+)-Tryptophan L-Tryptophan 2-Dimethylaminoethyl chloride hydrochloride Acetophenone 2-Chloro-N-(2,6-dimethylphenyl)acetamide
Chloroacetic acid N-(4-BROMOPHENYL)-2-CHLOROACETAMIDE 2-CHLORO-N-(2-METHYLPHENYL)ACETAMIDE 2-Chloro-N-phenylacetamide 4-Phenylphenacyl chloride
2-Chloro-N,N-diethylacetamide 2-PROPIONYLFURAN 3-(2-CHLORO-ACETYL)-3H-BENZOOXAZOL-2-ONE AKOS BBS-00005410

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Chloroacetic anhydride Suppliers

Global( 185)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Mojin Biotechnology Co., Ltd 		+8613288715578 sales@hbmojin.com China 12456 58
Shaanxi Haibo Biotechnology Co., Ltd 		+undefined18602966907 qinhe02@xaltbio.com China 1000 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Shanghai Arbor Chemical Co., Ltd. 		021-60451682 act@arborchemical.com CHINA 906 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10248 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 6992 58
Hebei Guanlang Biotechnology Co., Ltd. 		+86-19930503282 alice@crovellbio.com China 8823 58
Xiamen AmoyChem Co., Ltd 		+86-592-6051114 +8618959220845 sales@amoychem.com China 6387 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22968 58
Supplier Advantage
Hebei Mojin Biotechnology Co., Ltd 		58
Shaanxi Haibo Biotechnology Co., Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
Shanghai Arbor Chemical Co., Ltd. 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
Jinan Carbotang Biotech Co.,Ltd. 		58
Hebei Guanlang Biotechnology Co., Ltd. 		58
Xiamen AmoyChem Co., Ltd 		58
Hubei xin bonus chemical co. LTD 		58

View Lastest Price from Chloroacetic anhydride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Chloroacetic anhydride pictures 2024-04-12 Chloroacetic anhydride
541-88-8
 US $0.00-0.00 / kg 1kg 97% 10000 Mt/Year Shaanxi Haibo Biotechnology Co., Ltd
Chloroacetic anhydride pictures 2023-06-27 Chloroacetic anhydride
541-88-8
 US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
Chloroacetic Anhydride pictures 2023-03-06 Chloroacetic Anhydride
541-88-8
 US $10.50 / KG 1KG 99% 10 ton Hebei Guanlang Biotechnology Co,.LTD

Chloroacetic anhydride Spectrum

Chloroacetic anhydride(541-88-8)1HNMRChloroacetic anhydride(541-88-8)13CNMRChloroacetic anhydride(541-88-8)IR1Chloroacetic anhydride(541-88-8)Raman

541-88-8(Chloroacetic anhydride)Related Search:

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4-Aminobenzamidine dihydrochloride 3-[(3-AMINO-4-METHYLAMINO-BENZOYL)-PYRIDIN-2-YL-AMINO]-PROPIONIC ACID ETHYL ESTER HEXYL CHLOROFORMATE N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-(2-pyridinyl)-beta-alanine ethyl ester hydrochloride DICHLOROACETIC ANHYDRIDE
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chloro-aceticacianhydride Chloroacetyl anhydride chloroacetylanhydride chloroethanoicanhydride sym-dichloroaceticanhydride CHLOROACETIC ANHYDRIDE BIS(CHLOROACETIC)ANHYDRIDE 2-chloroaceticanhydride Aceticacid,chloro-,anhydride alpha,alpha’-dichloroaceticanhydride Chloracetic anhydride chloraceticanhydride CHLOROACETIC ANHYDRIDE, TECH., APPROX. 9 0% Chloroaceticanhydride,97% (Bischloroacetic acid) anhydride NSC 71207 1,5-Dichloro-3-oxapentan-2,4-dione, 1,5-Dichloro-2,4-dioxo-3-oxapentane Chloroacetic anhydride, tech., 90% Chloroacetic anhydride 97% Chloroacetic anhydride. 90%, tech Monochloroaceitc acid anhydride syMDichloroaceitc anhydride Chloroacetic anhydride, 97% 25GR oroacetic anhydride Acetic acid, 2-chloro-, 1,1'-anhydride 541-88-8 Chloroacetic anhydride Monochloroacetic anhydride CHLOROACETIC ACID ANHYDRIDE 2-Chloroacetic anhydride MONOCHLOROACETIC ACID ANHYDRIDE 541-88-8 ClCH2CO2O C4H4O3Cl C4H4Cl2O3 Organic Building Blocks Building Blocks Carbonyl Compounds Carboxylic Acid Anhydrides Building Blocks Carbonyl Compounds Carboxylic Acid Anhydrides Chemical Synthesis Organic Building Blocks Pharmaceutical Intermediates