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Salicylamide

Salicylamide
Salicylamide structure
CAS No.
65-45-2
Chemical Name:
Salicylamide
Synonyms
OHB;Acket;Samid;Cidal;Salrin;sr4326;Anamid;h.p.34;Oramid;Algamon
CBNumber:
CB4854078
Molecular Formula:
C7H7NO2
Formula Weight:
137.14
MOL File:
65-45-2.mol

Salicylamide Properties

Melting point:
140-144 °C(lit.)
Boiling point:
270°C
Density 
1,175 g/cm3
refractive index 
1.5323 (estimate)
Flash point:
181°C/14mm
storage temp. 
Inert atmosphere,Room Temperature
solubility 
methanol: 0.1 g/mL, clear
pka
pKa 8.13(H2O t = 37) (Uncertain)
form 
Crystalline Powder
color 
White
Odor
Odorless
PH Range
5 (0.2% aq soln)
Water Solubility 
<0.1 g/100 mL at 20 ºC
Decomposition 
270°C
Merck 
14,8328
BRN 
742439
Stability:
Stable. Light sensitive. Incompatible with strong bases, strong oxidizing agents.
InChIKey
SKZKKFZAGNVIMN-UHFFFAOYSA-N
CAS DataBase Reference
65-45-2(CAS DataBase Reference)
FDA 21 CFR
310.545
EWG's Food Scores
1
FDA UNII
EM8BM710ZC
ATC code
N02BA05
NIST Chemistry Reference
Benzamide, 2-hydroxy-(65-45-2)
EPA Substance Registry System
o-Hydroxybenzamide (65-45-2)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P280a-P304+P340-P405-P501a-P261-P305+P351+P338-P301+P312+P330
Hazard Codes  Xn
Risk Statements  22-36/37/38-20/21/22
Safety Statements  26-36
RIDADR  3249
WGK Germany  3
RTECS  VN6475000
TSCA  Yes
HazardClass  6.1(b)
PackingGroup  III
HS Code  29214300
Toxicity LD50 orally in mice: 1.4 g/kg (Hart)
NFPA 704
1
2 0

Salicylamide price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 84230 Salicylamide puriss., ≥99.0% (T) 65-45-2 1kg $60.4 2021-03-22 Buy
Sigma-Aldrich 1608000 Salicylamide United States Pharmacopeia (USP) Reference Standard 65-45-2 200mg $366 2021-03-22 Buy
TCI Chemical S0006 Salicylamide >98.0%(T) 65-45-2 25g $15 2021-03-22 Buy
TCI Chemical S0006 Salicylamide >98.0%(T) 65-45-2 500g $56 2021-03-22 Buy
Alfa Aesar A10797 Salicylamide, 98% 65-45-2 250g $26 2020-06-24 Buy

Salicylamide Chemical Properties,Uses,Production

Description

Salicylamide is less acidic (pKa 8.2) than other salicylic acid derivatives. Although poorly soluble in water, stable solutions can be formed at pH 9 through ionization of the phenolic group. It is absorbed from the GI tract on oral administration and is rapidly metabolized to inactive metabolites by intestinal mucosa, but not by hydrolysis. Activity appears to reside in the intact molecule. Salicylamide is approximately 40 to 55% plasma protein bound, and it competes with other salicylates and acetaminophen for glucuronide conjugation, decreasing the extent of conjugation of these other drugs.

Chemical Properties

white or light pink crystals or powder

Uses

Medicine (analgesic).

Uses

salicylamide is an analgesic, fungicide, and anti-inflammatory ingredient used to soothe the skin. Salicylamide is an aromatic amide.

Definition

ChEBI: The simplest member of the class of salicylamides derived from salicylic acid.

General Description

Salicylamide, o-hydroxybenzamide, is a derivative of salicylicacid that is fairly stable to heat, light, and moisture. Itreportedly exerts a moderately quicker and deeper analgesiceffect than aspirin because of quicker CNS penetration. Its metabolismdiffers from aspirin, because it is not metabolized tosalicylic acid but rather excreted exclusively as the ether glucuronideor sulfate. Thus, as a result of lack of contributionfrom salicylic acid, it has a lower analgesic and antipyretic efficacythan that of aspirin. However, it can be used in place ofsalicylates for patients with a demonstrated sensitivity to salicylates.It is also excreted much more rapidly than other salicylates,which accounts for its lower toxicity. It is available inseveral nonprescription products, in combination with acetaminophenand phenyltoloxamine (e.g., Rid-A Pain compound,Cetazone T, Dolorex, Ed-Flex, Lobac) or with aspirin,acetaminophen, and caffeine (e.g., Saleto, BC Powder).

General Description

Odorless white or slightly pink crystals. Bitter taste, leaves a sensation of warmth on the tongue. pH (saturated aqueous solution at 82°F) about 5. Sublimation begins at the melting point.

Air & Water Reactions

Salicylamide darkens on exposure to air. . Insoluble in water.

Reactivity Profile

Salicylamide is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). Salicylamide may be sensitive to prolonged exposure to light.

Fire Hazard

Flash point data for Salicylamide are not available; however, Salicylamide is probably combustible.

Clinical Use

Whereas salicylamide is reported to be as effective as aspirin as an analgetic/antipyretic and is effective in relieving pain associated with arthritic conditions, it does not appear to possess useful anti-inflammatory activity. Thus, indications for the treatment of arthritic disease states are unwarranted, and its use is restricted to the relief of minor aches and pain at a dosage of 325 to 650 mg three or four times per day. Its effects in humans are not reliable, however, and its use is not widely recommended.

Purification Methods

Crystallise the amide from water or repeatedly from CHCl3 [Nishiya et al. J Am Chem Soc 108 3880 1986]. [Beilstein 10 IV 169.] The anilide [87-17-2] M 213.2, m 135o crystallises from H2O. [Beilstein 12 H 500, 12 I 268, 12 II 256, 12 944.]

Salicylamide Preparation Products And Raw materials

Raw materials

Preparation Products


Salicylamide Suppliers

Global( 429)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20012 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20914 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Shanghai Time Chemicals CO., Ltd.
+8618017249410 +86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1365 55
Shanxi Naipu Import and Export Co.,Ltd
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Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5892 58
Xiamen AmoyChem Co., Ltd
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Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58

View Lastest Price from Salicylamide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-30 Salicylamide
65-45-2
US $31.00 / KG 1KG 99.9% 1000kg/month Shanxi Lianxu New Material Co., LTD
2021-11-30 Salicylamide
65-45-2
US $45.00 / Kg/Bag 1KG 99% 10T Baoji Guokang Bio-Technology Co., Ltd.
2021-11-30 Salicylamide
65-45-2
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD

Salicylamide Spectrum


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