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Salicylamide

Salicylamide
Salicylamide structure
CAS No.
65-45-2
Chemical Name:
Salicylamide
Synonyms
OHB;Cidal;Acket;Samid;Anamid;h.p.34;Oramid;Salrin;sr4326;Benesal
CBNumber:
CB4854078
Molecular Formula:
C7H7NO2
Formula Weight:
137.14
MOL File:
65-45-2.mol

Salicylamide Properties

Melting point:
140-144 °C(lit.)
Boiling point:
270°C
Density 
1,175 g/cm3
refractive index 
1.5323 (estimate)
Flash point:
181°C/14mm
storage temp. 
Refrigerator
solubility 
methanol: 0.1 g/mL, clear
pka
pKa 8.13(H2O t = 37) (Uncertain)
form 
Crystalline Powder
color 
White
Water Solubility 
<0.1 g/100 mL at 20 ºC
Merck 
14,8328
BRN 
742439
Stability:
Stable. Light sensitive. Incompatible with strong bases, strong oxidizing agents.
CAS DataBase Reference
65-45-2(CAS DataBase Reference)
NIST Chemistry Reference
Benzamide, 2-hydroxy-(65-45-2)
EPA Substance Registry System
Benzamide, 2-hydroxy-(65-45-2)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn
Risk Statements  22-36/37/38-20/21/22
Safety Statements  26-36
RIDADR  3249
WGK Germany  3
RTECS  VN6475000
TSCA  Yes
HazardClass  6.1(b)
PackingGroup  III
Hazardous Substances Data 65-45-2(Hazardous Substances Data)
Toxicity LD50 orally in mice: 1.4 g/kg (Hart)
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Salicylamide price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 84230 Salicylamide puriss., ≥99.0% (T) 65-45-2 1kg $57 2018-11-13 Buy
Sigma-Aldrich 1608000 Salicylamide United States Pharmacopeia (USP) Reference Standard 65-45-2 200mg $348 2018-11-13 Buy
TCI Chemical S0006 Salicylamide >98.0%(T) 65-45-2 25g $14 2018-11-22 Buy
TCI Chemical S0006 Salicylamide >98.0%(T) 65-45-2 500g $56 2018-11-22 Buy
Alfa Aesar A10797 Salicylamide, 98% 65-45-2 250g $24.4 2018-11-13 Buy

Salicylamide Chemical Properties,Uses,Production

Chemical Properties

white or light pink crystals or powder

Uses

Medicine (analgesic).

Uses

salicylamide is an analgesic, fungicide, and anti-inflammatory ingredient used to soothe the skin. Salicylamide is an aromatic amide.

Definition

ChEBI: The simplest member of the class of salicylamides derived from salicylic acid.

General Description

Salicylamide, o-hydroxybenzamide, is a derivative of salicylicacid that is fairly stable to heat, light, and moisture. Itreportedly exerts a moderately quicker and deeper analgesiceffect than aspirin because of quicker CNS penetration. Its metabolismdiffers from aspirin, because it is not metabolized tosalicylic acid but rather excreted exclusively as the ether glucuronideor sulfate. Thus, as a result of lack of contributionfrom salicylic acid, it has a lower analgesic and antipyretic efficacythan that of aspirin. However, it can be used in place ofsalicylates for patients with a demonstrated sensitivity to salicylates.It is also excreted much more rapidly than other salicylates,which accounts for its lower toxicity. It is available inseveral nonprescription products, in combination with acetaminophenand phenyltoloxamine (e.g., Rid-A Pain compound,Cetazone T, Dolorex, Ed-Flex, Lobac) or with aspirin,acetaminophen, and caffeine (e.g., Saleto, BC Powder).

General Description

Odorless white or slightly pink crystals. Bitter taste, leaves a sensation of warmth on the tongue. pH (saturated aqueous solution at 82°F) about 5. Sublimation begins at the melting point.

Air & Water Reactions

Salicylamide darkens on exposure to air. . Insoluble in water.

Reactivity Profile

Salicylamide is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). Salicylamide may be sensitive to prolonged exposure to light.

Fire Hazard

Flash point data for Salicylamide are not available; however, Salicylamide is probably combustible.

Purification Methods

Crystallise the amide from water or repeatedly from CHCl3 [Nishiya et al. J Am Chem Soc 108 3880 1986]. [Beilstein 10 IV 169.] The anilide [87-17-2] M 213.2, m 135o crystallises from H2O. [Beilstein 12 H 500, 12 I 268, 12 II 256, 12 944.]

Salicylamide Preparation Products And Raw materials

Raw materials

Preparation Products


Salicylamide Suppliers

Global( 290)Suppliers
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Salicylamide Spectrum


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