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Carbazole

Introduction Extraction Production
Carbazole
Carbazole
CAS No.
86-74-8
Chemical Name:
Carbazole
Synonyms
Skf 20091;CARBAZOLE;usafek-600;USAF ek-600;'LGC' (2409);9H-CARBAZOLE;Diphenylimid;DIPHENYLIMIDE;9-AZAFLUORENE;Dibenzopyrrol
CBNumber:
CB4854492
Molecular Formula:
C12H9N
Formula Weight:
167.21
MOL File:
86-74-8.mol

Carbazole Properties

Melting point:
243-246 °C(lit.)
Boiling point:
355 °C(lit.)
Density 
1.1
vapor pressure 
400 mm Hg ( 323 °C)
refractive index 
1.6192 (estimate)
Flash point:
220 °C
storage temp. 
2-8°C
solubility 
acetone: soluble50mg/mL
form 
Crystalline Powder, Flakes, or Chunks
color 
Beige-yellow or beige-brownish
Water Solubility 
<0.1 g/100 mL at 19 ºC
Merck 
14,1790
BRN 
3956
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents, nitrogen oxides, potassium hydroxide.
CAS DataBase Reference
86-74-8(CAS DataBase Reference)
NIST Chemistry Reference
Carbazole(86-74-8)
EPA Substance Registry System
9H-Carbazole(86-74-8)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,N,T
Risk Statements  22-36/37/38-40-50/53-63-43-23/24/25-45-67-68-51/53
Safety Statements  26-36-60-61-36/37-24/25-23-53-45-36/37/39
RIDADR  UN 2811 6.1/PG 3
WGK Germany  2
RTECS  FE3150000
10
Hazard Note  Harmful
TSCA  Yes
HazardClass  9
PackingGroup  III
HS Code  29339990
Hazardous Substances Data 86-74-8(Hazardous Substances Data)
Toxicity LD50 orally in rats: >5 g/kg (Eagle, Carlson)
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
H336 May cause drowsiness or dizziness Specific target organ toxicity,single exposure; Narcotic effects Category 3 Warning P261, P271, P304+P340, P312,P403+P233, P405, P501
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning P273, P391, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning P273, P391, P501
H413 May cause long lasting harmful effects to aquatic life Hazardous to the aquatic environment, long-term hazard Category 4
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P281 Use personal protective equipment as required.
P391 Collect spillage. Hazardous to the aquatic environment
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.
P501 Dispose of contents/container to..…

Carbazole price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 442506 Carbazole analytical standard 86-74-8 1EA $36.6 2017-11-08 Buy
Sigma-Aldrich 1096702 Carprofen Related Compound A United States Pharmacopeia (USP) Reference Standard 86-74-8 50mg $1110 2017-11-08 Buy
TCI Chemical C0032 Carbazole >97.0%(GC) 86-74-8 25g $27 2017-11-08 Buy
TCI Chemical C0032 Carbazole >97.0%(GC) 86-74-8 100g $79 2017-11-08 Buy
Alfa Aesar A11448 Carbazole, 95% 86-74-8 50g $25 2018-11-13 Buy

Carbazole Chemical Properties,Uses,Production

Introduction

Carbazole and its derivatives are a class of important nitrogen-containing heterocyclic compounds possessing various unique properties and biological activity.
Carbazole is a colorless small scale crystal, insoluble in water and inorganic acid, slightly soluble in ethanol, ether, acetone, benzene (in high temperature), soluble in chloroform, glacial acetic acid, carbon disulfide, pyridine and furfural, etc. It has intense fluorescence and prolonged phosphorescence under ultraviolet light.

Extraction

Sulfuric acid method
Dissolve crude anthracene in chlorobenzene or other solvents to remove soluble phenanthrenes, quinones, etc. Insoluble anthracene and carbazoles are then reacted with concentrated sulfuric acid, and then carbazole sulfate is generated departing from the anthracene. The carbazole sulfate is hydrolyzed, filtered and dried to obtain carbazole.

Solvent-rectification method
Dissolve crude anthracene with heavy benzene, and remove soluble phenanthrene, quinone and other substances. Insoluble anthracene and carbazole are rectified in a rectification tower to obtain a mixture containing 85 to 90% of carbazole with a yield of 65%.

Pyridine solvent method
Dissolve crude anthracene with heavy benzene, and remove soluble phenanthrene, quinone and other substances. Then pyridine is used as a solvent to filter off insoluble anthracene at 90°C, and the filtrate is then crystallized to obtain crude carbazole. The crude carbazole can be treated with chlorobenzene or other solvents to obtain carbazole with yield of 97 to 99%.

Production

a. Graebe-Ullmann:
Diazotization from amino diphenylamine, and nitrogen gas heated off to generate carbazole. Reported by Graebe and Ullmann in 1896.
b. Bucherer:
Co-thermal reaction of aryl hydrazine and naphthol in the presence of sodium bisulfite. Reported by Bucherer in 1904.
c. Borsche Drechsel:
Hydrazone is synthesized by condensation of Benzoquinone and cyclohexanone, and the latter cyclized to tetrahydrocarbazole under acidic conditions and then catalyzed by dehydrogenation to generate carbazole. Reported by Drechsel and Borsche in 1868 and 1904 respectively.



Thanks to the development of the catalytic dehydrogenation method, the Borsche method has become a carbazole synthetic route with simple operation, mild conditions, low cost and high yield, and has a high industrial production value.
Because of its unique structure and physicochemical properties, carbazole has aroused great interest among researchers. In recent years, novel mono- and poly-substituted carbazole derivatives have been found to have good anti-tumor and anti-convulsant activities, showing broad application prospects. The demand for carbazole and its derivatives has been increasing. In the last decade of the 20th century, a large number of novel precious metals and transition metal catalysts have been used in the synthesis of carbazoles and their derivatives, which greatly enriched the synthetic methods and lay the foundation of synthesizing more complex carbazole derivatives. Nowadays, not only carbazole, but tens of thousands of carbazole derivatives are synthesized by new methods, and are widely used in the pharmaceutical and dye industries.

Chemical Properties

white crystals or light brown powder

Uses

Important dye intermediate. Used in making photographic plates sensitive to ultraviolet light. Reagent for lignin, carbohydrates, and formaldehyde.

General Description

White crystals, plates, leaflets or light tan powder. Sublimes readily. Exhibits strong fluorescence and long phosphorescence on exposure to ultraviolet light.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Carbazole is an extremely weak base. Carbazole is incompatible with strong oxidizing agents. Carbazole reacts with nitrogen oxides. Potassium hydroxide fusion yields a salt.

Fire Hazard

Flash point data for Carbazole are not available; however, Carbazole is probably combustible.

Purification Methods

Dissolve carbazole (60g) in conc H2SO4 (300mL), extract with three 200mL portions of *benzene, then stir this into 1600mL of an ice-water mixture. The precipitate is filtered off, washed with a little water, dried, recrystallised from *benzene and then from pyridine/*benzene [Feldman et al. J Am Chem Soc 73 4341 1951]. It has also been recrystallised from EtOH or toluene, sublimed in vacuum, zone-refined, and purified by TLC. [UV: Armarego in Physical Methods in Heterocyclic Chemistry (Ed Katritzky, Academic Press) Vol III 158 1971, Beilstein 20/8 V 9.]

Carbazole Preparation Products And Raw materials

Raw materials

Preparation Products


Carbazole Suppliers

Global( 286)Suppliers
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Capot Chemical Co.,Ltd.
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ATK CHEMICAL COMPANY LIMITED
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AB PharmaTech,LLC
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View Lastest Price from Carbazole manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-09 Carbazole
86-74-8
US $2.00 / KG 1KG 99% customise

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