Ceramides
- CAS No.
- 100403-19-8
- Chemical Name:
- Ceramides
- Synonyms
- CERAMIDE 3;CERAMIDE 2;CERAMIDE 1;Ceramides NP;CERAMIDE 6 II;CERAMIDE 5;CeramideNP;Aqua Ceramide;Ceramide 3B;Ceramide W.S
- CBNumber:
- CB4874731
- Molecular Formula:
- C24H47NO3
- Molecular Weight:
- 397.63488
- MDL Number:
- MFCD00282862
- MOL File:
- 100403-19-8.mol
| storage temp. | Store at -20°C |
|---|---|
| solubility | Methanol: 25 mg/mL |
| form | A crystalline solid |
| LogP | 13.577 (est) |
| CAS DataBase Reference | 100403-19-8(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 4370DF050B |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P |
Ceramides price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 22853 | Ceramides Mixture | 100403-19-8 | 25mg | $178 | 2024-03-01 | Buy |
| ChemScene | CS-0062889 | CeramidesMixture ≥98.0% | 100403-19-8 | 25mg | $220 | 2021-12-16 | Buy |
| ChemScene | CS-0062889 | CeramidesMixture ≥98.0% | 100403-19-8 | 50mg | $330 | 2021-12-16 | Buy |
| ChemScene | CS-0062889 | CeramidesMixture ≥98.0% | 100403-19-8 | 100mg | $495 | 2021-12-16 | Buy |
Ceramides Chemical Properties,Uses,Production
Description
The ceramides mixture consists of hydroxy and non-hydroxy fatty acid-containing ceramides. Ceramides are generated from sphingomyelin through activation of sphingomyelinases or through the de novo synthesis pathway, which requires the coordinated action of serine palmitoyl transferase and ceramide synthase. They have been shown to mediate antiproliferative responses such as apoptosis, growth arrest, differentiation, and senescence.
Uses
ceramides is a family of naturally occurring lipids that act primarily in the skin’s uppermost layer, forming a protective barrier and reducing natural transepidermal water loss. Ceramides repair the stratum corneum layer in cases of dry skin, improve skin hydration, and increase the feeling of softness. They are beneficial for stressed, sensitive, scaly, rough, dry, aged, and sun-damaged skin. Ceramides play an essential role in the structure of superficial epidermal layers and form an integral part of the intercellular membrane network. They help generate and sustain the skin’s barrier function. This is extremely important: if the stratum corneum’s hydration is maintained, then it functions more normally in terms of flexibility and desquamation, its integrity is upheld, and the skin is less susceptible to irritation. Ceramide production decreases with age, accentuating any tendency to dry skin. When incorporated into a skin care preparation, the topical application of ceramides could benefit the stratum corneum if the ceramides manage to fill the intercellular spaces and if they are hydrolyzed by the correct extracellular enzymes on the skin. Such application also can stimulate ceramide production in the skin, thereby increasing the skin’s natural lipid content and reinforcing the skin’s protective barrier, measured through transepidermal water loss. Topically applied ceramides have been shown to capture and bind water, necessary for the skin to remain supple, smooth, and hydrated. natural ceramides are obtained from animals and plants. While ceramides can be synthetically manufactured, it is hard to obtain an identical equivalent to those found in nature, making them expensive raw materials.
Uses
Ceramides are widely used in cosmetics, including shampoos, deodorants and make-up.
Mechanism of action
Ceramides, fatty acid and cholesterol constitute the extracellular lipid matrix of epidermal barrier in an approximately equimolar ratio and are assembled in a dense orthorhombic lateral packing within SC interstices. Among them, ceramides are central to the permeability barrier structure and function. Epidermal ceramides account for approximately 50 % of total epidermal lipid by weight. In addition, ceramides also act as an active second messenger, regulate keratinocyte proliferation and differentiation, enhance proinflammatory cytokines production, and modulate immune responses. Aberrant metabolism and function of ceramides is involved in the pathogenesis of several inflammatory skin diseases, including psoriasis, atopic dermatitis (AD) and ichthyosis[1-2].
References
[1] Li, Qingyang , et al. "The Role of Ceramides in Skin Homeostasis and Inflammatory Skin Diseases." Journal of Dermatological Science 97.1(2019).
[2] Koenig, David W., and B. Minerath. "Ceramidase control: An approach to improving skin health."Journal of cosmetic science 59.4(2008):354-355.
Ceramides Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chongqing Zhihe Biopharmaceutical Co., Ltd. | +86-18580541567 +86-17782035140 | sales@zhswyy.com | China | 338 | 58 |
| Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 | xie@china-sinoway.com | China | 992 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
| BINBO BIOLOGICAL CO.,LTD | +8618629063126 | info@binbobiological.com | China | 224 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| Hebei Yime New Material Technology Co., Ltd. | +86-66697723 +86-17703311139 | admin@china-yime.com | China | 563 | 58 |
| Hangzhou ICH Biofarm Co., Ltd | +undefined8613073685410 | sales@ichemie.com | China | 985 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 1000 | 58 |
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | admin@guyunchem.com | China | 616 | 58 |
| Wuhan Quanjinci New Material Co.,Ltd. | +8615271838296 | kyra@quanjinci.com | China | 1532 | 58 |
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View Lastest Price from Ceramides manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-19 | Ceramide 3
100403-19-8
|
US $365.00 / KG | 1KG | 99% | 1000kg | Hebei Yime New Material Technology Co., Ltd. | |
 |
2024-04-19 | Ceramide NP
100403-19-8
|
US $365.00 / KG | 1KG | 99% | 1000kg | Hebei Yime New Material Technology Co., Ltd. | |
 |
2024-04-12 | Ceramides
100403-19-8
|
US $0.00 / kg | 1kg | 99% | 2000ton | Shaanxi Haibo Biotechnology Co., Ltd |
-
- Ceramide 3
100403-19-8
- US $365.00 / KG
- 99%
- Hebei Yime New Material Technology Co., Ltd.
-
- Ceramide NP
100403-19-8
- US $365.00 / KG
- 99%
- Hebei Yime New Material Technology Co., Ltd.
-
- Ceramides
100403-19-8
- US $0.00 / kg
- 99%
- Shaanxi Haibo Biotechnology Co., Ltd