misonidazole
- CAS No.
- 13551-87-6
- Chemical Name:
- misonidazole
- Synonyms
- SRI-1354;Ro 7-0582;Ro-07-0582;NSC-261037;Aids028846;Aids-028846;misonidazole;1-(2-NITRO-1-IMIDAZOLYL-1)3-METHOXYPROPANOL;α-(Methoxymethyl)-2-nitro-1H-imidazole-1-ethanol;1-Methoxy-3-(2-nitro-1H-imidazol-1-yl)propan-2-ol
- CBNumber:
- CB4876199
- Molecular Formula:
- C7H11N3O4
- Molecular Weight:
- 201.181
- MDL Number:
- MFCD00866600
- MOL File:
- 13551-87-6.mol
| Melting point | 107-109°C |
|---|---|
| Boiling point | 339.09°C (rough estimate) |
| Density | 1.3983 (rough estimate) |
| refractive index | 1.6500 (estimate) |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly, Heated), Methanol (Slightly, Sonicated) |
| form | Solid |
| pka | 13.49±0.20(Predicted) |
| color | Yellow to Orange |
| FDA UNII | 8FE7LTN8XE |
| NCI Drug Dictionary | misonidazole |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| NFPA 704 |
|
misonidazole price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 15606 | Misonidazole ≥95% | 13551-87-6 | 1mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 15606 | Misonidazole ≥95% | 13551-87-6 | 5mg | $107 | 2024-03-01 | Buy |
| Cayman Chemical | 15606 | Misonidazole ≥95% | 13551-87-6 | 10mg | $151 | 2024-03-01 | Buy |
| Cayman Chemical | 15606 | Misonidazole ≥95% | 13551-87-6 | 50mg | $357 | 2024-03-01 | Buy |
| TRC | M368700 | Misonidazole | 13551-87-6 | 100mg | $180 | 2021-12-16 | Buy |
misonidazole Chemical Properties,Uses,Production
Description
Misonidazole is a nitroimidazole with radiosensitizing and antineoplastic properties. Nitroimidazoles, including misonidazole, specifically accumulate as nitro anion radicals and their metabolites in hypoxic cells. The metabolites of misonidazole can themselves be cytotoxic or they can increase the chemosensitivity and radiosensitivity of the target cells. Misonidazole and derivatives, including fluoromisonidazole, are used in the imaging of hypoxic regions in tumors and in the cardiovascular system.
Uses
Misonidazole can be used as a potential hypoxic cancer cell radiosensitizer and DNA binding and nicking agent. The metabolites of misonidazole can themselves be cytotoxic or they can increase the chemosensitivity and radiosensitivity of the target cells
Uses
Antiprotozoal (Trichomonas).
in vitro
in cultured cho cells, pretreatment with 5 mm miso for 2 hr exihibited the marginal toxicity [2].
in vivo
pretreatment with misonidazole (miso) enhanced the number of cross-links formed in a fibrosarcoma and in the spleen and gut of mice for periods up to 48 h following a single injection of melphalan (mel). miso pretreatment could result in a greater amount of binding of mel to dna at early times after injection. miso may exert its affect by inhibiting the repair of cross-links or monoadducts at early times post-injection [3].
References
[1] josephy p d, palcic b, skarsgard l d. ascorbate-enhanced cytotoxicity of misonidazole[j]. nature, 1978, 271(5643): 370-372.
[2]taylor y c, bump e a, brown j m. studies on the mechanism of chemosensitization by misonidazole in vitro[j]. international journal of radiation oncology biology physics, 1982, 8(3-4): 705-708.
[3] murray d, meyn r e. enhancement of the dna cross-linking activity of melphalan by misonidazole in vivo[j]. british journal of cancer, 1983, 47(2): 195.
[4] wasserman t h, stetz j a, phillips t l.
misonidazole Preparation Products And Raw materials
Raw materials
Preparation Products
misonidazole Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Tongchuang Pharma(Suzhou). Co., Ltd. | 0512-63263366 18912765016 | tongtf110@sina.com | China | 1010 | 62 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 400-400-8210725 4008210725 | malulu@leyan.com | China | 55023 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44894 | 58 |
| TCI (Shanghai) Chemical Trading Co., Ltd. | 021-61109150 | sales@tcisct.com | China | 31183 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24131 | 58 |
| Shaanxi Dideu Newmaterial Co., Ltd. | 029-63373950 15353716720 | 1052@dideu.com | China | 10007 | 58 |
| LGC Science (Shanghai) Ltd. | 17717235263 | cindy.yang@lgcgroup.com | China | 11437 | 58 |