ChemicalBook >> CAS DataBase List >>CDK4/6-IN-6
CDK4/6-IN-6
- CAS No.
- 2380321-51-5
- Chemical Name:
- CDK4/6-IN-6
- Synonyms
- PF-07220060;CDK4/6-IN-6;CDK4-IN-I (PF-07220060);CDK4/6-IN-6, 10 mM in DMSO;CDK4/6-IN-6CDK4/CDK4/6-IN-66-IN-6;CDK-4/6-IN-6,Inhibitor,inhibit,CDK,Cyclin,Cyclin dependent kinase,CDK4/6 IN 6,CDK4/6IN6;(3S,4R)-4-[[5-chloro-4-[7-fluoro-2-(1-hydroxy-1-methyl-ethyl)-3-isopropyl-benzimidazol-5-yl]pyrimidin-2-yl]amino]tetrahydropyran-3-ol;(3S,4R)-4-((5-Chloro-4-(4-fluoro-2-(2-hydroxypropan-2-yl)-1-isopropyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)tetrahydro-2H-pyran-3-ol;1,5-anhydro-3-((5-chloro-4-[4-fluoro-2-(2-hydroxypropan-2-yl)-1-(propan-2-yl)-1 H-benzimidazol-6- yl]pyrimidin-2-yl)amino)-2,3-dideoxy-D-threo-pentitol
- CBNumber:
- CB48845087
- Molecular Formula:
- C22H27ClFN5O3
- Molecular Weight:
- 463.94
- MDL Number:
- MOL File:
- 2380321-51-5.mol
Last updated:2024-11-19 20:33:22
CDK4/6-IN-6 Chemical Properties,Uses,Production
Biological Activity
CDK4/6-IN-6 (example A94) is a potent CDK4/CDK6 inhibitor with a Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively[1]. CDK4/6-IN-6 (example A94) has IC50s of 38.5 nM and 144.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3 using phospho-Rb S795 ELISA assays in JEKO-1 and MV4-1 1 cells[1].
References
[1]. Ping Chen, et al. 2-amino-pyridine or 2-amino-pyrimidine derivatives as cyclin dependent kinase inhibitors. WO2019207463A1.
CDK4/6-IN-6 Preparation Products And Raw materials
Raw materials
Preparation Products
CDK4/6-IN-6 Suppliers
Global( 53)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32965 | 60 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
TargetMol Chemicals Inc. | support@targetmol.com | United States | 38631 | 58 | |
Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5127 | 58 |
Suzhou Haiben Pharmaceutical Co., Ltd | 14760821013 13564957716 | 1816280386@qq.com | China | 8045 | 58 |
Taizhou Nanfeng Pharmaceutical Research Institute | 18616377689 | nanfengdrug@163.com | China | 20010 | 58 |
Chengdu PEIP Pharmaceutical Technology Co., LTD. | 028-61715638 18011352545 | 1242335275@qq.com | China | 369 | 58 |
Suzhou Meidi Senuo Pharmaceutical Technology Co., Ltd. | 13771642864 | snhuyu_2008@126.com | China | 1113 | 58 |
Bayee Biotech (Anqing) Co., Ltd. | 0556-5032306 18917961636 | wtx@bayeebio.com | China | 264 | 61 |
View Lastest Price from CDK4/6-IN-6 manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2024-11-19 | CDK4/6-IN-6
2380321-51-5
|
US $115.00-397.00 / mg | 95.63% | 10g | TargetMol Chemicals Inc. |
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- CDK4/6-IN-6
2380321-51-5
- US $115.00-397.00 / mg
- 95.63%
- TargetMol Chemicals Inc.
CDK4/6-IN-6
1,5-anhydro-3-((5-chloro-4-[4-fluoro-2-(2-hydroxypropan-2-yl)-1-(propan-2-yl)-1 H-benzimidazol-6- yl]pyrimidin-2-yl)amino)-2,3-dideoxy-D-threo-pentitol
PF-07220060
CDK4/6-IN-6CDK4/CDK4/6-IN-66-IN-6
CDK-4/6-IN-6,Inhibitor,inhibit,CDK,Cyclin,Cyclin dependent kinase,CDK4/6 IN 6,CDK4/6IN6
(3S,4R)-4-[[5-chloro-4-[7-fluoro-2-(1-hydroxy-1-methyl-ethyl)-3-isopropyl-benzimidazol-5-yl]pyrimidin-2-yl]amino]tetrahydropyran-3-ol
CDK4-IN-I (PF-07220060)
(3S,4R)-4-((5-Chloro-4-(4-fluoro-2-(2-hydroxypropan-2-yl)-1-isopropyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)tetrahydro-2H-pyran-3-ol
CDK4/6-IN-6, 10 mM in DMSO
2380321-51-5