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CDK4/6-IN-6

CAS No.
2380321-51-5
Chemical Name:
CDK4/6-IN-6
Synonyms
PF-07220060;CDK4/6-IN-6;CDK4-IN-I (PF-07220060);CDK4/6-IN-6, 10 mM in DMSO;CDK4/6-IN-6CDK4/CDK4/6-IN-66-IN-6;CDK-4/6-IN-6,Inhibitor,inhibit,CDK,Cyclin,Cyclin dependent kinase,CDK4/6 IN 6,CDK4/6IN6;(3S,4R)-4-[[5-chloro-4-[7-fluoro-2-(1-hydroxy-1-methyl-ethyl)-3-isopropyl-benzimidazol-5-yl]pyrimidin-2-yl]amino]tetrahydropyran-3-ol;(3S,4R)-4-((5-Chloro-4-(4-fluoro-2-(2-hydroxypropan-2-yl)-1-isopropyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)tetrahydro-2H-pyran-3-ol;1,5-anhydro-3-((5-chloro-4-[4-fluoro-2-(2-hydroxypropan-2-yl)-1-(propan-2-yl)-1 H-benzimidazol-6- yl]pyrimidin-2-yl)amino)-2,3-dideoxy-D-threo-pentitol
CBNumber:
CB48845087
Molecular Formula:
C22H27ClFN5O3
Molecular Weight:
463.94
MDL Number:
MOL File:
2380321-51-5.mol
Last updated:2024-11-19 20:33:22

CDK4/6-IN-6 Properties

Boiling point 687.4±65.0 °C(Predicted)
Density 1.46±0.1 g/cm3(Predicted)
storage temp. 4°C, protect from light
solubility DMSO : 250 mg/mL (538.87 mM; Need ultrasonic)
form Solid
pka 13.43±0.29(Predicted)
color White to off-white

CDK4/6-IN-6 Chemical Properties,Uses,Production

Biological Activity

CDK4/6-IN-6 (example A94) is a potent CDK4/CDK6 inhibitor with a Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively[1]. CDK4/6-IN-6 (example A94) has IC50s of 38.5 nM and 144.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3 using phospho-Rb S795 ELISA assays in JEKO-1 and MV4-1 1 cells[1].

References

[1]. Ping Chen, et al. 2-amino-pyridine or 2-amino-pyrimidine derivatives as cyclin dependent kinase inhibitors. WO2019207463A1.

CDK4/6-IN-6 Preparation Products And Raw materials

Raw materials

Preparation Products

CDK4/6-IN-6 Suppliers

Global( 53)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32965 60
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
Wuhan Jingkang en Biomedical Technology Co., Ltd
+8613720134139 orders@jknbiochem.com China 5221 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 5127 58
Suzhou Haiben Pharmaceutical Co., Ltd 14760821013 13564957716 1816280386@qq.com China 8045 58
Taizhou Nanfeng Pharmaceutical Research Institute 18616377689 nanfengdrug@163.com China 20010 58
Chengdu PEIP Pharmaceutical Technology Co., LTD. 028-61715638 18011352545 1242335275@qq.com China 369 58
Suzhou Meidi Senuo Pharmaceutical Technology Co., Ltd. 13771642864 snhuyu_2008@126.com China 1113 58
Bayee Biotech (Anqing) Co., Ltd. 0556-5032306 18917961636 wtx@bayeebio.com China 264 61

View Lastest Price from CDK4/6-IN-6 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
CDK4/6-IN-6 pictures 2024-11-19 CDK4/6-IN-6
2380321-51-5
US $115.00-397.00 / mg 95.63% 10g TargetMol Chemicals Inc.
  • CDK4/6-IN-6 pictures
  • CDK4/6-IN-6
    2380321-51-5
  • US $115.00-397.00 / mg
  • 95.63%
  • TargetMol Chemicals Inc.
CDK4/6-IN-6 1,5-anhydro-3-((5-chloro-4-[4-fluoro-2-(2-hydroxypropan-2-yl)-1-(propan-2-yl)-1 H-benzimidazol-6- yl]pyrimidin-2-yl)amino)-2,3-dideoxy-D-threo-pentitol PF-07220060 CDK4/6-IN-6CDK4/CDK4/6-IN-66-IN-6 CDK-4/6-IN-6,Inhibitor,inhibit,CDK,Cyclin,Cyclin dependent kinase,CDK4/6 IN 6,CDK4/6IN6 (3S,4R)-4-[[5-chloro-4-[7-fluoro-2-(1-hydroxy-1-methyl-ethyl)-3-isopropyl-benzimidazol-5-yl]pyrimidin-2-yl]amino]tetrahydropyran-3-ol CDK4-IN-I (PF-07220060) (3S,4R)-4-((5-Chloro-4-(4-fluoro-2-(2-hydroxypropan-2-yl)-1-isopropyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)tetrahydro-2H-pyran-3-ol CDK4/6-IN-6, 10 mM in DMSO 2380321-51-5