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Virginiamycin S1

CAS No.
23152-29-6
Chemical Name:
Virginiamycin S1
Synonyms
VirginiaMycin coMplex;Antibiotic 899;Staphylomycin S;Verginiamycin S1;Virginiamycin S1;Antibiotic 1754Z3B;Antibiotic 899, Staphylomycin S;StaphyloMycin S, PA 114B2, 899, A1745Z3B, Factor S;N-[(3-Hydroxy-2-pyridinyl)carbonyl]cyclo[L-Thr*-D-Abu-L-Pro-N-methyl-L-Phe-4-oxo-L-pipecoloyl-L-phenyl Gly-];N-[(3-Hydroxy-2-pyridyl)carbonyl]cyclo(L-Thr*-D-Abu-L-Pro-N-methyl-L-Phe-4-oxo-L-2-piperidinecarbonyl-L-phenyl Gly-)
CBNumber:
CB4887230
Molecular Formula:
C43H49N7O10
Molecular Weight:
823.89
MDL Number:
MFCD00864857
MOL File:
23152-29-6.mol
Last updated:2023-05-18 11:31:04

Virginiamycin S1 Properties

Melting point 240-242°
alpha D20 -28° (c = 1 in ethanol)
storage temp. -20°C
solubility methanol: soluble5mg/mL
form powder
color white
FDA UNII J91D5GN5AT

SAFETY

Risk and Safety Statements

Precautionary statements  P271-P261-P280
WGK Germany  3
HS Code  2941900000

Virginiamycin S1 price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich V4140 Virginiamycin S1 ≥99% (HPLC) 23152-29-6 5mg $471 2024-03-01 Buy
Cayman Chemical 17455 Virginiamycin S1 ≥99% 23152-29-6 5mg $326 2024-03-01 Buy
Cayman Chemical 17455 Virginiamycin S1 ≥99% 23152-29-6 25mg $1141 2024-03-01 Buy
TRC V673813 Virginiamycin S1 23152-29-6 1mg $255 2021-12-16 Buy
Usbiological V2123-59 Virginiamycin Complex 23152-29-6 5mg $523 2021-12-16 Buy
Product number Packaging Price Buy
V4140 5mg $471 Buy
17455 5mg $326 Buy
17455 25mg $1141 Buy
V673813 1mg $255 Buy
V2123-59 5mg $523 Buy

Virginiamycin S1 Chemical Properties,Uses,Production

Uses

Virginiamycin S1 is a main component of virginiamycin preparations.

Uses

Virginiamycin complex is defined as a mixture of 75% ostreogrycin A (virginamycin M1) and 25% virginiamycin S1, together with the less abundant S analogues. As the two major components have quite different solubilities, these proportions are not readily achieved or used. BioAustralis has isolated and re-combined the individual components to provide the defined components of virginiamycin complex. The composition of the complex is important as Virginiamycin S1 acts a synergist, binding to the conformational change of the peptidyl transferase centre of the 50S ribosome induced by ostreogrycin A.

Uses

Virginiamycin S1 is one of a family of depsipeptide antibiotics co-produced with ostreogrycin A and used as a synergistic mixture. Virginiamycin S1 acts a synergist, binding to the conformational change of the peptidyl transferase centre of the 50S ribosome induced by ostreogrycin A.

Biological Activity

virginiamycin s1 is a macrolide antibiotic that reversibly inhibits protein synthesis [1][2][3].virginiamycin complex contains two antibiotics, virginiamycin m1 and virginiamycin s1. streptogramins are divided into class a and class b based on their structures. virginiamycin s1 is a member of the streptogramin b group of antibiotics, which bind the peptide exit tunnel to inhibit the elongation stage of translation. they show good bactericidal activity against methicillin-resistant s. aureus (mrsa), although resistance in mrsa is conferred by the cfr gene. virginiamycin m1 has activity against gram-positive and in select cases gram-negative bacteria. combination of group a and b streptogramins exhibit bactericidal activity [1]. virginiamycin s1 acted synergistically with virginiamycin m1 to irreversibly inhibit protein synthesis in bacteria. in cell-free systems, virginiamycin m1 and virginiamycin s1 bound to the large ribosomal subunit, and the affinity of ribosomes for vs is increased by vm [2][3].

Contact allergens

Like the other streptogramin, pristinamycin, virginiamycin is made of two subunits, virginiamycin S1 and virginiamycin M1. Dermatitis was quite common in people using the formerly available topical virginiamycin. Occupational dermatitis was observed in the pharmaceutical industry, in breeders, and in a surgeon who used topical virginiamycin on postoperative wounds (personal observation).

References

[1]. fair rj, tor y. antibiotics and bacterial resistance in the 21st century. perspect medicin chem. 2014 aug 28;6:25-64.
[2]. kehrenberg c, cuny c, strommenger b, et al. methicillin-resistant and -susceptible staphylococcus aureus strains of clonal lineages st398 and st9 from swine carry the multidrug resistance gene cfr. antimicrob agents chemother. 2009 feb;53(2):779-81.
[3]. parfait r, cocito c. lasting damage to bacterial ribosomes by reversibly bound virginiamycin m. proc natl acad sci u s a. 1980 sep;77(9):5492-6.

Virginiamycin S1 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 47)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
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BOC Sciences
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Alta Scientific Co., Ltd. 022-6537-8550 15522853686 sales@altasci.com.cn China 4515 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9709 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 18892239720 psaitong@jm-bio.com China 12308 58
Lynnchem 86-(0)29-85992781 17792393971 info@lynnchem.com China 4587 58
Novachemistry 44-20819178-90 02081917890 info@novachemistry.com United Kingdom 4381 58
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 13028896684 sales@rrkchem.com China 55477 58
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9730 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Virginiamycin S1 Antibiotic 1754Z3B N-[(3-Hydroxy-2-pyridinyl)carbonyl]cyclo[L-Thr*-D-Abu-L-Pro-N-methyl-L-Phe-4-oxo-L-pipecoloyl-L-phenyl Gly-] N-[(3-Hydroxy-2-pyridyl)carbonyl]cyclo(L-Thr*-D-Abu-L-Pro-N-methyl-L-Phe-4-oxo-L-2-piperidinecarbonyl-L-phenyl Gly-) Staphylomycin S Cebin V, Eskalin V, EskaMicin, Stafac, StephyloMycin, MikaMycin, Ostreogrycin, Patricin, PristinaMycin, StreptograMin, VernaMycin. Antibiotic 899, Staphylomycin S StaphyloMycin S, PA 114B2, 899, A1745Z3B, Factor S Verginiamycin S1 Antibiotic 899 VirginiaMycin coMplex 23152-29-6 C43H49N7O10 antibiotic