tromantadine
- CAS No.
- 53783-83-8
- Chemical Name:
- tromantadine
- Synonyms
- N-(1-Adamantyl)-2-[2-(dimethylamino)ethoxy]acetamide;Acetamide, 2-[2-(dimethylamino)ethoxy]-N-tricyclo[3.3.1.13,7]dec-1-yl-
- CBNumber:
- CB4917021
- Molecular Formula:
- C16H28N2O2
- Molecular Weight:
- 280.41
- MDL Number:
- MFCD00869480
- MOL File:
- 53783-83-8.mol
| Boiling point | 434.5±28.0 °C(Predicted) |
|---|---|
| Density | 1.09±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 14.58±0.20(Predicted) |
| FDA UNII | H191JFG8WA |
tromantadine Chemical Properties,Uses,Production
Description
Tromantadine is an antiviral medicine used to treat herpes simplex virus. It is available in a topical gel under trade names Viru-Merz and Viru-Merz Serol. Its performance is similar to aciclovir.
Mechanism of action
Tromantadine inhibits the early and late events in the virus replication cycle.It changes the glycoproteins of the host cells, therefore impeding the absorption of the virus. It inhibits penetration of the virus. It also prevents uncoating of the virions.
Originator
Viru-Merz,Merz,W. Germany,1973
Uses
Tromantadine hydrochloride is used as antiviral agent effective against herpes simplex infections.
Definition
ChEBI: Tromantadine is a secondary carboxamide.
Manufacturing Process
Adamantane is first reacted with chloroacetyl chloride to give
chloroacetylaminoadamantane.
2.3 g Na (0.1 g-atom) were dissolved in 75 ml dimethylamino-ethanol. Then
the excess alcohol was distilled off completely and the sodium salt developed
was dried in a vacuum. After drying, the salt was dissolved in about 200 ml
xylene. To thissolution.22.8 g (0.1 mol) chloroacetylaminoadamantane were added, heated for 10 hours under reflux in a 250-ml round-bottomed flask
with a reflux cooler, and the sodium chloride developed subsequently filtered
off.
Next the xylene was distilled away, the liquid residue dissolved in about 80 ml
carbon tetrachloride and the hydrochloride precipitated through introduction of
hydrochloric acid gas. The hydrochloride was dissolved in about 100 ml
acetone and the solvent subsequently distilled away, whereby excess
hydrochloric acid passed over with it. This operation was repeated until no
excess acid was present.
A large excess of petroleum ether was added in a 500 ml three-necked flask
provided with a stirrer and reflux cooler, to a concentrated acetonic solution of
the hydrochloride and stirred for at least 1 hour, whereby the desired
substance was deposited in a crystalline form. Finally, the substance was
filtered away and dried in a desiccator. 14 g of the substance (15% of theory)
were obtained.
Therapeutic Function
Antiviral
tromantadine Preparation Products And Raw materials
tromantadine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49999 | 58 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2127 | 70 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12338 | 58 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| Beijing Hechemist Technology CO.,LTD | 18511709189 | sales@hechemist.com | China | 3436 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12308 | 58 |