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xibornol

CAS No.
13741-18-9
Chemical Name:
xibornol
Synonyms
xibornol;Xybornol;Bactacine;Nanbacine;6-Isobornyl-3,4-xylenol;4,5-dimethyl-2-[(1R,3R,4S)-4,7,7-trimethyl-3-bicyclo[2.2.1]heptanyl]phenol;Phenol, 4,5-dimethyl-2-[(1R,2S,4S)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl]-, rel-
CBNumber:
CB4923798
Molecular Formula:
C18H26O
Molecular Weight:
258.4
MDL Number:
MFCD00864988
MOL File:
13741-18-9.mol
Last updated:2022-12-21 16:56:50

xibornol Properties

Melting point 94-96°
Boiling point bp3 165-168°; bp9 185-189°
Density d420 1.0240
refractive index nD20 1.5382 (Starkov, Glushkova)
FDA UNII RQ12GMY0FZ
ATC code J01XX02

xibornol price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation API0025568 XIBORNOL 95.00% 13741-18-9 5MG $497.29 2021-12-16 Buy
Product number Packaging Price Buy
API0025568 5MG $497.29 Buy

xibornol Chemical Properties,Uses,Production

Chemical Properties

Crystalline solid or viscous, yellowish liquid.

Originator

Nanbacine,Fournier,France,1976

Uses

Antibacterial agent, rubber antioxidant.

Definition

ChEBI: A bridged compound that is 3,4-xylenol carrying an additional isobornyl substituent at position 6. A lipophilic antibacterial drug mainly used in spray dosage forms for the local treatment of infection and inflammation of the throat.

Manufacturing Process

100 g of 3,4-xylenol and 150 g of camphene are melted in a two-necked flask equipped with a reflux condenser and a thermometer. 10 g of stannic chloride are added in small quantities; the temperature is kept between 70°C and 80°C for 4 hours. The mass is then allowed to cool and 300 ml of benzene and 300 ml of water are added. The aqueous layer is decanted off, and the supernatant organic layer is washed, first with 1,200 ml of 10% potassium hydroxide and then with water until neutral. The benzene is driven off and the mass is distilled. The fraction which passes between 203°C and 223°C/200 mm Hg is collected and recrystallized in petroleum ether.
100 mg of the recrystallized product is dissolved in 10 ml of hexane.
This solution is then slowly passed through a chromatographic alumina column, 20 cm in length and 16 mm in diameter, containing 20 g of alumina (Prolabo).
The column is then eluted with benzene and 2 ml fractions of the eluent are collected as soon as the product appears in the eluent. The presence of the product is detected by means of the color change in the collected eluent after adding 1 drop of 2% ferric chloride and 2 drops of 5% potassium ferricyanide solution.
18 ml of a first fraction are collected, the next 2 ml of eluent are discarded and then a second fraction of 20 ml is collected. Removal of the solvent from the first fraction by distillation leaves a product having a melting point of between 94°C and 96°C and removal of the solvent from the second fraction leaves a product having a melting point between 86°C and 88°C.
The product remaining from the first fraction is 6-isobornyl-3,4-xylenol while that from the second fraction is its isomer 6-exo-isocamphenyl-3,4-xylenol.

Therapeutic Function

Antibacterial

xibornol Preparation Products And Raw materials

Raw materials

Preparation Products

xibornol Suppliers

Global( 13)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
+1-781-999-5354 support@targetmol.com United States 19973 58
GIHI CHEMICALS CO.,LIMITED
+8618058761490 info@gihichemicals.com China 50001 58
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 14059 65
BOC Sciences 16314854226 info@bocsci.com United States 9926 65
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24131 58
Shaanxi Dideu Newmaterial Co., Ltd. 029-63373950 15353716720 1052@dideu.com China 10011 58
Hubei Qingbei Yunyan Pharmaceutical Technology Co., Ltd 18162595016 3287908757@qq.com China 9627 58
6-Isobornyl-3,4-xylenol Nanbacine Xybornol xibornol Phenol, 4,5-dimethyl-2-[(1R,2S,4S)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl]-, rel- Bactacine 4,5-dimethyl-2-[(1R,3R,4S)-4,7,7-trimethyl-3-bicyclo[2.2.1]heptanyl]phenol 13741-18-9