cGAMP disodium
- CAS No.
- 2407516-83-8
- Chemical Name:
- cGAMP disodium
- Synonyms
- cGAMP disodium;3',3'-cGAMP disodium;3',3'-cGAMP disodium);cGAMP disodium (Cyclic GMP-AMP disodium
- CBNumber:
- CB49272783
- Molecular Formula:
- C20H25N10NaO13P2
- Molecular Weight:
- 698.41
- MDL Number:
- MOL File:
- 2407516-83-8.mol
cGAMP disodium Chemical Properties,Uses,Production
Uses
cGAMP (Cyclic GMP-AMPP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators[1][2][3][4].
Biological Activity
cGAMP disodium (Cyclic GMP-AMP disodium) is the third cyclic dinucleotide (CDN) to be discovered in bacteria. cGAMP disodium is an effective adjuvant for sublingual vaccination capable of promoting broad immunity including serum anti-PA neutralizing and anti-PA SIgA responses in airway secretions[1][2].
in vivo
cGAMP (5 μg; nostril mucosal adjuvant) disodium promotes the antigen-specific cytokine production by spleen cells of immunized mice[2].
| Animal Model: | Female C57BL/6 (H-2b) mice 6-8 weeks old[2] |
| Dosage: | 5 μg |
| Administration: | Nostril mucosal adjuvant |
| Result: | Higher titers of ovalbumin (OVA)-specific IgA and total IgG as well as IgG1 and IgG2c in the sera of mice immunized with cGAMP-adjuvanted OVA as compared to sera from OVA-immunized mice. |
IC 50
Human Endogenous Metabolite
storage
Store at -20°C
References
[1]. Wright TA, et al. Second messengers and divergent HD-GYP phosphodiesterases regulate 3’,3’-cGAMP signaling. Mol Microbiol. 2020;113(1):222-236.
cGAMP disodium Preparation Products And Raw materials
Raw materials
Preparation Products
cGAMP disodium Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38671 | 58 | |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4645 | 55 | |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2960 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 17801761073 | 3193328036@qq.com | China | 29763 | 68 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29770 | 58 |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6753 | 58 |
View Lastest Price from cGAMP disodium manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-30 | cGAMP disodium
2407516-83-8
|
US $2128.00-1458.00 / mg | 10g | TargetMol Chemicals Inc. |
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- cGAMP disodium
2407516-83-8
- US $2128.00-1458.00 / mg
- TargetMol Chemicals Inc.