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(±)-alpha-[[(tert-butyl)amino]methyl]-7-ethyl-2-benzofuranmethanol hydrochloride

CAS No.
60398-91-6
Chemical Name:
(±)-alpha-[[(tert-butyl)amino]methyl]-7-ethyl-2-benzofuranmethanol hydrochloride
Synonyms
Einecs 262-216-3;KJBONRGCLLBWCJ-UHFFFAOYSA-O;Bufuralol hydrochloride (Ro 3-4787);α-[(tert-Butylamino)methyl]-7-ethyl-2-benzofuranmethanol hydrochloride;(1)-alpha-(((tert-Butyl)amino)methyl)-7-ethyl-2-benzofuranmethanolhydr ochloride
CBNumber:
CB4939096
Molecular Formula:
C16H24ClNO2
Molecular Weight:
297.82026
MDL Number:
MFCD00272648
MOL File:
60398-91-6.mol
Last updated:2023-06-08 09:02:20

(±)-alpha-[[(tert-butyl)amino]methyl]-7-ethyl-2-benzofuranmethanol hydrochloride Properties

Melting point 143-146 °C
storage temp. 2-8°C
solubility H2O: soluble
form solid
color white to off-white
FDA UNII G66IY7Q7S4

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3
NFPA 704
0
2 0

(±)-alpha-[[(tert-butyl)amino]methyl]-7-ethyl-2-benzofuranmethanol hydrochloride price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich UC168 (±)-Bufuralol hydrochloride 60398-91-6 5mg $1440 2024-03-01 Buy
Sigma-Aldrich UC168 (±)-Bufuralol hydrochloride 60398-91-6 10mg $2550 2024-03-01 Buy
Cayman Chemical 17794 Bufuralol (hydrochloride) ≥95% 60398-91-6 1mg $81 2024-03-01 Buy
Cayman Chemical 17794 Bufuralol (hydrochloride) ≥95% 60398-91-6 5mg $356 2024-03-01 Buy
Cayman Chemical 17794 Bufuralol (hydrochloride) ≥95% 60398-91-6 10mg $505 2024-03-01 Buy
Product number Packaging Price Buy
UC168 5mg $1440 Buy
UC168 10mg $2550 Buy
17794 1mg $81 Buy
17794 5mg $356 Buy
17794 10mg $505 Buy

(±)-alpha-[[(tert-butyl)amino]methyl]-7-ethyl-2-benzofuranmethanol hydrochloride Chemical Properties,Uses,Production

Description

Bufuralol hydrochloride (Ro 3-4787 hydrochloride) is a potent non-selective, orally active β-adrenoreceptor antagonist with partial agonist activity. Bufuralol hydrochloride is a CYP2D6 probe substrate.

Uses

A β-Adrenergic blocker with peripheral vasodilating activity. Antianginal; antihypertensive.

Uses

CYP2D6 substrate

Biochem/physiol Actions

Bufuralol hydrochloride is known to be a non-specific β-receptor inhibitor that has an affinity for β 1 and β 2 receptors. Furthermore, studies have reported that bufuralol hydrochloride can decrease isoproterenol peripheral resistance.

in vitro

Bufuralol is widely used in the characterization of CYP2D6 activity, and possesses aromatic rings and a basic nitrogen that are characteristic of CYP2D6 substrates.

in vivo

Bufuralol metabolism mediated by NADPH exhibits biphasic kinetics and is less efficient than that observed in the presence of cumene hydroperoxide (CuOOH) in and monkey intestines, in agreement with the observations in the livers.

References

[1] fothergill ga, francis rj, hamilton tc, osbond jm, parkes mw. bufuralol, a new beta-adrenoceptor blocking agent. experientia. 1975 nov 15;31(11):1322-3.
[2] pringle, t. h.,francis, r.j.,east, p.b., et al. pharmacodynamic and pharmacokinetic studies on bufuralol in man. br.j.clin.pharmac. 22, 527-534 (1986).

(±)-alpha-[[(tert-butyl)amino]methyl]-7-ethyl-2-benzofuranmethanol hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

(±)-alpha-[[(tert-butyl)amino]methyl]-7-ethyl-2-benzofuranmethanol hydrochloride Suppliers

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(1)-alpha-(((tert-Butyl)amino)methyl)-7-ethyl-2-benzofuranmethanolhydr ochloride α-[(tert-Butylamino)methyl]-7-ethyl-2-benzofuranmethanol hydrochloride Einecs 262-216-3 KJBONRGCLLBWCJ-UHFFFAOYSA-O Bufuralol hydrochloride (Ro 3-4787) 60398-91-6 Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals