ETAZOLATE
- CAS No.
- 35838-58-5
- Chemical Name:
- ETAZOLATE
- Synonyms
- Nsc163611;Etazolate hydrochloride solid;Ethyl 1-ethyl-4-(isopropylidenehydrazino)-1H-pyrazolo[3,4-B]pyridine-5-carboxylate monohydrochloride;1-ethyl-4-[(1-methylethylidene)hydrazino]1h-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester hydrochloride;1H-Pyrazolo[3,4-B]pyridine-5-carboxylic acid, 1-ethyl-4-[(1-methylethylidene)hydrazino]-, ethyl ester, monohydrochloride;SQ20009, 1-Ethyl-4-[(1-methylethylidene)hydrazino]1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester hydrochloride
- CBNumber:
- CB4972600
- Molecular Formula:
- C14H18N5O2HCl
- Molecular Weight:
- 0
- MDL Number:
- MFCD00209848
- MOL File:
- 35838-58-5.mol
- MSDS File:
- SDS
| Melting point | 193-194 °C |
|---|---|
| storage temp. | room temp |
| solubility | H2O: >20mg/mL (Solutions should be freshly prepared.) |
| form | solid |
| color | white |
| FDA UNII | 7YO3254Y6B |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
ETAZOLATE price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | E889255 | Etazolate hydrochloride | 35838-58-5 | 10mg | $575 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008346 | ETAZOLATE HYDROCHLORIDE 95.00% | 35838-58-5 | 25MG | $1024.78 | 2021-12-16 | Buy |
| ApexBio Technology | B6304 | Etazolate hydrochloride | 35838-58-5 | 10mM(in 1mL H2O) | $50 | 2021-12-16 | Buy |
| ApexBio Technology | B6304 | Etazolate hydrochloride | 35838-58-5 | 10mg | $99 | 2021-12-16 | Buy |
| ApexBio Technology | B6304 | Etazolate hydrochloride | 35838-58-5 | 50mg | $419 | 2021-12-16 | Buy |
ETAZOLATE Chemical Properties,Uses,Production
Uses
Antipsychotic.
Uses
Etazolate Hydrochloride is an acyclic nucleotide phosphodiesterase 4 inhibitor, which also exhibits antidepressant-like activity in acute and chronic mouse and rat model of depression.
Biological Activity
etazolate hydrochloride is a pde-4 inhibitor and selective gaba-a receptor modulator [3].pde-4 modulates the release of inflammatory mediators through camp-dependent and -independent mechanisms. selective targeting pde-4 is a novel therapeutic approach in the treatment of inflammation-associated respiratory diseases, such as asthma and copd (chronic obstructive pulmonary disease) [1].in rat neuronal cortical cells, etazolate hydrochloride (0.2 μm) induced sappα through the stimulation of the α-secretase pathway, and exerted a neuroprotective effect against aβ which was associated with sappα induction via the gaba-a receptor [2].in 159 alzheimer’s disease patients, etazolate hydrochloride in combination with one achei (acetycholinesterase inhibitor) was shown to be safe and generally well tolerated in the phase iia study over a 3-month treatment period [3].
Biochem/physiol Actions
Selective inhibitor of cAMP-specific phosphodiesterase.
References
[1] dastidar s g, rajagopal d, ray a. therapeutic benefit of pde4 inhibitors in inflammatory diseases.[j]. current opinion in investigational drugs, 2007, 8(5):364-72.
[2] marcade m, bourdin j, loiseau n, et al. etazolate, a neuroprotective drug linking gaba(a) receptor pharmacology to amyloid precursor protein processing.[j]. journal of neurochemistry, 2008, 106(1):392-404.
[3] vellas b; sol o; snyder pj; ousset pj; haddad r; maurin m; lemarié jc; désiré l; pando mp; eht0202/002 study group. eht0202 in alzheimer's disease: a 3-month, randomized, placebo-controlled, double-blind study.[j]. current alzheimer research, 2011, 8(2):203-12.
ETAZOLATE Preparation Products And Raw materials
Raw materials
Preparation Products
ETAZOLATE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Lanzhou Angeli Biochemical Technology Co., Ltd. | 0931-8235634 13321316780 | 1455540579@qq.com | China | 959 | 55 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| Shanghai Yingxin laboratory equipment Co., Ltd | 021-021-59178156 15300768757 | 359382369@qq.com | China | 10367 | 58 |
| Shanghai Guchen Biotechnology Co., LTD | 021-34675735 19147740836 | 1986399151@qq.com | China | 9849 | 58 |