ChemicalBook >> CAS DataBase List >>GW4869
GW4869
- CAS No.
- 6823-69-4
- Chemical Name:
- GW4869
- Synonyms
- GW 4869 (hydrochloride hydrate);CS-2410;GW4869(2);GW4869(1);GW4869 HCl;GW4869 2HCl;GW4869/GW-4869;GW69A， GW554869A;GW4869 USP/EP/BP;N-SMase Inhibitor
- CBNumber:
- CB4972736
- Molecular Formula:
- C30H29ClN6O2
- Molecular Weight:
- 541.05
- MDL Number:
- MFCD06411564
- MOL File:
- 6823-69-4.mol
- MSDS File:
- SDS
Last updated:2023-05-18 11:31:07
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| HS Code | 2933299090 |
GW4869 price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D1692 | GW4869 ≥90% (NMR) | 6823-69-4 | 5mg | $236 | 2024-03-01 | Buy |
| Cayman Chemical | 13127 | GW 4869 (hydrochloride hydrate) ≥90% | 6823-69-4 | 500μg | $33 | 2024-03-01 | Buy |
| Cayman Chemical | 13127 | GW 4869 (hydrochloride hydrate) ≥90% | 6823-69-4 | 1mg | $62 | 2024-03-01 | Buy |
| Sigma-Aldrich | D1692 | GW4869 ≥90% (NMR) | 6823-69-4 | 25mg | $851 | 2024-03-01 | Buy |
| Cayman Chemical | 13127 | GW 4869 (hydrochloride hydrate) ≥90% | 6823-69-4 | 5mg | $160 | 2024-03-01 | Buy |
GW4869 Chemical Properties,Uses,Production
Uses
GW4869 has been used:
- as an inhibitor of neutral sphingomyelinase and exosome biogenesis
- to analyse the effects of arsenic trioxide (ATO) treatment for hepatoma carcinoma HCCLM3 cells on ceramide production
- to determine the contributions of p75 neurotrophin receptor (p75NTR) and tropomyosin receptor kinase A (TrkA)- coupled pathways to nerve growth factor (NGF)-induced thermal hypersensitivity in rats
General Description
GW4869 is a commonly used pharmacological agent, which inhibits exosome generation. It blocks ceramide-mediated inward budding of multivesicular bodies (MVBs) and the release of mature exosomes from MVBs. GW4869 exhibits cytotoxicity to phosphatidylserine-expressing myeloma cells. It inhibits the secretion of IFN (interferon)-α by plasmacytoid dendritic cells?(pDCs).
Biochem/physiol Actions
A cell-permeable, potent, specific, non-competitive inhibitor of N-SMase (neutral sphingomyelinase)
GW4869 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 86)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | 18522618860@163.com | China | 694 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29474 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9571 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
View Lastest Price from GW4869 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-08-18 | GW4869 USP/EP/BP
6823-69-4
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited | |
 |
2019-12-23 | GW4869
6823-69-4
|
US $1.00 / g | 1g | 99.99% | 200kg | Career Henan Chemical Co |
-
- GW4869 USP/EP/BP
6823-69-4
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- GW4869
6823-69-4
- US $1.00 / g
- 99.99%
- Career Henan Chemical Co
N-SMase Inhibitor
2-PropenaMide, 3,3'-(1,4-phenylene)bis[N-[4-(4,5-dihydro-1H-iMidazol-2-yl)phenyl]-, hydrochloride (1:2)
4',4''-Di-2-imidazolin-2-yl-p-benzenediacrylanilide dihydrochloride
GW4869/GW-4869
N-SMase Inhibitor, GW4869 - CAS 6823-69-4 - Calbiochem
CS-2410
GW4869 dihydrochloride
GW4869;GW 4869 HYDROCHLORIDE HYDRATE
GW4869(1)
GW4869(2)
GW69A， GW554869A
GW4869 USP/EP/BP
GW4869 2HCl
p-Benzenediacrylanilide, 4′,4′′-di-2-imidazolin-2-yl-, dihydrochloride
GW4869 HCl
GW 4869 (hydrochloride hydrate)
GW-4869,Inhibitor,Phospholipase,GW4869,inhibit
6823-69-4
C30H28N6O22HCl
C30H30N6Cl2O2
API
A cell-permeable, symmetrical dihydroimidazolo-amide compound that acts as a potent, specific, non-competitive inhibitor of N-SMase.