NUTLIN-3
- CAS No.
- 548472-68-0
- Chemical Name:
- NUTLIN-3
- Synonyms
- CS-390;NUTLIN-3;(?)-NUTLIN-3;Nutlin-3, >=98%;NUTLIN3;NUTLIN 3;Nutlin-3 ((±NUTLIN-3 (Free base);MDM2 Antagonist, Nutlin-3, Racemic;MDM2 Antagonist, Nutlin-3, Racemic - CAS 548472-68-0 - Calbiochem;4-(4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbony
- CBNumber:
- CB5101900
- Molecular Formula:
- C30H30Cl2N4O4
- Molecular Weight:
- 581.49
- MDL Number:
- MFCD07784509
- MOL File:
- 548472-68-0.mol
- MSDS File:
- SDS
| Melting point | >132oC (dec.) |
|---|---|
| Density | 1.36±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: 20 mg/mL, soluble |
| form | solid |
| pka | 14.35±0.20(Predicted) |
| color | White |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| InChIKey | BDUHCSBCVGXTJM-UHFFFAOYSA-N |
| FDA UNII | 53IA0V845C |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
NUTLIN-3 price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | N6287 | Nutlin-3 ≥98% (HPLC), powder | 548472-68-0 | 1mg | $129 | 2024-03-01 | Buy |
| Sigma-Aldrich | 444143 | MDM2 Antagonist, Nutlin-3, Racemic | 548472-68-0 | 1mg | $144 | 2024-03-01 | Buy |
| Cayman Chemical | 10004372 | (±)-Nutlin-3 ≥98% | 548472-68-0 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 10004372 | (±)-Nutlin-3 ≥98% | 548472-68-0 | 5mg | $109 | 2024-03-01 | Buy |
| Sigma-Aldrich | N6287 | Nutlin-3 ≥98% (HPLC), powder | 548472-68-0 | 5mg | $442 | 2024-03-01 | Buy |
NUTLIN-3 Chemical Properties,Uses,Production
Description
(±)-Nutlin-3 is a racemic mixture of the p53-Mdm2 protein-protein interaction inhibitor (−)-nutlin-3 and its less active enantiomer (+)-nutlin-3 . In vivo, (±)-nutlin-3 (200 mg/kg twice daily) reduces tumor volume in an SJSA-1 osteosarcoma mouse xenograft model.
Uses
(+/-)-Nutlin-3 is a small molecule MDM2 antagonist.
Definition
ChEBI: 4-[[4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazol-1-yl]-oxomethyl]-2-piperazinone is a stilbenoid.
Biochem/physiol Actions
Nutlin-3, an antagonist of a human homolog of murine double minute 2 (HDM2). It has the ability to inhibit the HDM2-directed degradation of p53. Nutlin-3 can also enhance the transcriptional activities of p73.
storage
Store at -20°C
References
1) Vassilev et al. (2004), In vivo activation of the p53 pathway by small-molecule antagonists of MDM2; Science, 303 844 2) Ghassemifar et al. (2012), MDM2 antagonism by nutlin-3 induces death in human medulloblastoma cells; Neurosci. Lett., 513 106 3) Manfe et al. (2012), MDM2 inhibitor nutlin-3 induces apoptosis and senescence in cutaneous T-cell lymphoma: role of p53; J. Invest. Dermatol., 132 1487 4) Kunkele et al. (2012), Pharmacological activation of the p53 pathway by nutlin-3 exerts anti-tumoral effects in medulloblastomas; Neuro. Oncol., 14 859
NUTLIN-3 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| Henan Alfa Chemical Co., Ltd | +8618339805032 | alfa4@alfachem.cn | China | 12755 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
View Lastest Price from NUTLIN-3 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-13 | Nutlin (3)
548472-68-0
|
US $1.00 / g | 1g | 99% | 1ton | Career Henan Chemical Co |
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- Nutlin (3)
548472-68-0
- US $1.00 / g
- 99%
- Career Henan Chemical Co