FLICE
- CAS No.
- 179241-78-2
- Chemical Name:
- FLICE
- Synonyms
- MACH;MCH5;MASH;CAP4;FLICE;MCH51;MACH2;MACH-1;FLICE3;ALPS2B
- CBNumber:
- CB5104259
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD01865996
- MOL File:
- Mol file
| storage temp. | −70°C |
|---|---|
| form | buffered aqueous solution |
| FDA UNII | R0EEK1NCEH |
SAFETY
Risk and Safety Statements
| Hazard Codes | Xi,T |
|---|---|
| Risk Statements | 36/37/38-61 |
| Safety Statements | 26-36-45-53 |
| WGK Germany | 2 |
FLICE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SAB4503321 | Anti-CASP8 (Cleaved-Asp384), C-Terminal antibody produced in rabbit affinity isolated antibody | 100μG | $506 | 2024-03-01 | Buy | |
| Sigma-Aldrich | 218769 | Caspase-8, Human, Recombinant, E. coli Caspase-8, Human, Recombinant is expressed in E. coli as a single polypeptide. Fused at the N- and C- termini to a His?Tag sequence. Undergoes spontaneous autoprocessing to yield the active enzyme. | 3000U | $616 | 2023-06-20 | Buy | |
| Usbiological | C2087-33A | Caspase 8 | 179241-78-2 | 100ug | $509 | 2021-12-16 | Buy |
| Usbiological | 153890 | Caspase 8 | 179241-78-2 | 10ug | $356 | 2021-12-16 | Buy |
| Usbiological | 153891 | Caspase 8 | 179241-78-2 | 10ug | $356 | 2021-12-16 | Buy |
FLICE Chemical Properties,Uses,Production
General Description
Human recombinant C?terminal histidine tagged caspase 8 is expressed as the truncated pro-caspase 8 (amino acids 213?496). It is a fully active protein consisting of 18 kDa and 12.4 kDa subunits; the 12.4 kDa subunit contains the histidine tag.
Biochem/physiol Actions
Caspase 8 is at the top of the hierarchy of the caspase cascade and is considered an initiator caspase. It exists in the cell as an inactive 55?kDa proenzyme. It is converted to the active form, consisting of 18?kDa and 11?kDa subunits, upon its recruitment to the cytoplasmic domain of activated death receptors such as CD95 or TNFR via the adapter protein FADD. The activation of the proenzyme is triggered by the protein′s aggregation, which leads to auto- or transprocessing. Caspase?8 activates downstream caspases (caspases?3, 6, and 7) that cleave key cellular substrates and lead to apoptotic death of the cells.
FLICE Preparation Products And Raw materials
Raw materials
Preparation Products
FLICE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Creative Enzymes | 1-516-855-7709 | info@creative-enzymes.com | United States | 8748 | 58 |
| Shanghai Universal Biotech Co.,Ltd | 18768175414 | gaojun@univ-bio.com | China | 24998 | 58 |
| Supplier | Advantage |
|---|---|
| Creative Enzymes | 58 |
| Shanghai Universal Biotech Co.,Ltd | 58 |