1H-Purine-6,8-diamine (9CI)
- CAS No.
- 28128-33-8
- Chemical Name:
- 1H-Purine-6,8-diamine (9CI)
- Synonyms
- 1H-Purine-6,8-diamine (9CI)
- CBNumber:
- CB51080882
- Molecular Formula:
- C5H6N6
- Molecular Weight:
- 150.14
- MDL Number:
- MFCD18252947
- MOL File:
- 28128-33-8.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
1H-Purine-6,8-diamine (9CI) price More Price(8)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | A605423 | 8-Aminoadenine | 28128-33-8 | 2.5mg | $140 | 2021-12-16 | Buy |
ApexBio Technology | B5520 | 8-Aminoadenine | 28128-33-8 | 10mg | $165 | 2021-12-16 | Buy |
ApexBio Technology | B5520 | 8-Aminoadenine | 28128-33-8 | 50mg | $717 | 2021-12-16 | Buy |
Chemenu | CM236561 | 9H-Purine-6,8-diamine 95% | 28128-33-8 | 1g | $888 | 2021-12-16 | Buy |
Alichem | 28128338 | 9H-Purine-6,8-diamine | 28128-33-8 | 1g | $1016.5 | 2021-12-16 | Buy |
1H-Purine-6,8-diamine (9CI) Chemical Properties,Uses,Production
Uses
8-Aminoadenine is used in the synthetic preparation of purine derivatives as competitive inhibitors of human erythrocyte membrane phosphatidylinositol 4-kinase. It can also be useful in label-??free biosensing of RNA, and in the study of structure-activity relationships of adenine and deazaadenine derivatives as ligands for adenine receptors.
Biological Activity
8-aminoadenine is an agonist of adenine receptor with ki value of 0.0341 μm [1].adenine receptor is a g protein-coupled receptor activated by the nucleoside adenosine. there are four types of adenosine receptors: a1, a2a, a2b and a3. a1 and a2a receptors play an important role in the heart, regulating coronary blood flow and myocardial oxygen consumption. a2b and a3 receptors are involved in inflammation and immune responses.8-aminoadenine is an adenine receptor agonist with ki values of 0.0341 and 6.51 μm for human and rat, respectively. in hek293 cell membrane, 8-aminoadenine was more potent than adenine (ki = 0.0471 μm) and exhibited 190-fold more potent than the rat binding site. in 1321n1 astrocytoma cells expressing the rade1r, 8-aminoadenine (500 μm) inhibited isoproterenol-stimulated camp accumulation, which suggested that 8-aminoadenine inhibited adenine uptake [1].
References
[1]. borrmann t, abdelrahman a, volpini r, et al. structure-activity relationships of adenine and deazaadenine derivatives as ligands for adenine receptors, a new purinergic receptor family. j med chem, 2009, 52(19): 5974-5989.
1H-Purine-6,8-diamine (9CI) Preparation Products And Raw materials
1H-Purine-6,8-diamine (9CI) Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
Jiangsu aikang biomedical research and development co., LTD | 025-66110311 13155353615 | qzhang@aikonchem.com | China | 15527 | 58 |
BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24131 | 58 |
Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 4030 | 58 |
ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |