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2,3-Dichloroacetophenone

2,3-Dichloroacetophenone Structure
2,3-Dichloroacetophenone structure
CAS No.
56041-57-7
Chemical Name:
2,3-Dichloroacetophenone
Synonyms
1-(2,3-Dichlorophenyl)ethanone;2',3'-Dichloroacetophenone;Ketoconazole Impurity 47;2,3-Dichloroacetophenone;Ethanone,1-(2,3-dichlorophenyl)-;1-(2,3-DICHLOROPHENYL)ETHAN-1-ONE;2′,3′-Dichloroacetophenone, CAS 56041-57-7
CBNumber:
CB5108398
Molecular Formula:
C8H6Cl2O
Molecular Weight:
189.04
MDL Number:
MFCD00052988
MOL File:
56041-57-7.mol
MSDS File:
SDS
Last updated:2026-01-13 11:21:01
Product description Number Pack Size Price
2′,3′-dichloroacetophenone AldrichCPR CDS003602 250 mg $73.1
1-(2,3-Dichlorophenyl)ethanone B419383 100mg $70
2',3'-Dichloroacetophenone 95+% OR8271 5g $41
2',3'-Dichloroacetophenone 95.0% 2617-5-Y5 5G $45
2,3-Dichloroacetophenone FD137925 2g $50
More product size
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2,3-Dichloroacetophenone Properties

Melting point 125-127 °C
Boiling point 67 °C
Density 1.293
refractive index 1.558
Flash point 106-108°C/2mm
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Ethyl Acetate (Slightly)
form Solid
color Colourless
BRN 2438815
InChI InChI=1S/C8H6Cl2O/c1-5(11)6-3-2-4-7(9)8(6)10/h2-4H,1H3
InChIKey KMABBMYSEVZARZ-UHFFFAOYSA-N
SMILES C(=O)(C1=CC=CC(Cl)=C1Cl)C
CAS DataBase Reference 56041-57-7(CAS DataBase Reference)
FDA UNII WN2KG56TE3
UNSPSC Code 12352200

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P305+P351+P338-P405-P501a-P261-P280a-P304+P340
Hazard Codes  Xi,Xn
Risk Statements  36/38-36/37/38-22
Safety Statements  26-36/37/39-37/39-36
WGK Germany  WGK 3
Hazard Note  Irritant
HS Code  2914790090
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
NFPA 704
1
2 0

2,3-Dichloroacetophenone price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich CDS003602 2′,3′-dichloroacetophenone AldrichCPR 56041-57-7 250 mg $73.1 2025-07-31 Buy
TRC B419383 1-(2,3-Dichlorophenyl)ethanone 56041-57-7 100mg $70 2021-12-16 Buy
Apolloscientific OR8271 2',3'-Dichloroacetophenone 95+% 56041-57-7 5g $41 2021-12-16 Buy
SynQuest Laboratories 2617-5-Y5 2',3'-Dichloroacetophenone 95.0% 56041-57-7 5G $45 2021-12-16 Buy
Biosynth Carbosynth FD137925 2,3-Dichloroacetophenone 56041-57-7 2g $50 2021-12-16 Buy
Product number Packaging Price Buy
CDS003602 250 mg $73.1 Buy
B419383 100mg $70 Buy
OR8271 5g $41 Buy
2617-5-Y5 5G $45 Buy
FD137925 2g $50 Buy

2,3-Dichloroacetophenone Chemical Properties,Uses,Production

Chemical Properties

colorless to pale yellow liquid

Uses

2,3''-Dichloroacetophenone is used as a reagent in the synthesis of benzothiazepinones (BTZs) as novel non-ATP competitive inhibitors of glycogen synthase kinase-3β (GSK-3β). Also used as a reagent in the synthesis of benzimidazolyl pyridinones as insulin-like growth factor I (IGF-1R) kinase inhibitors.

Synthesis

1,2-Dichlorobenzene

95-50-1

2,3-Dichloroacetophenone

56041-57-7

Method A: A hexane solution of butyl lithium (300 mL, 0.474 mol) was slowly added dropwise to 1,2-dichlorobenzene (104.58 g, 0.711 mol) dissolved in dry tetrahydrofuran (2 L) under nitrogen protection, keeping the reaction temperature at -70°C. After the dropwise addition, the reaction solution was continued to be stirred for 1 hour at -70°C. The reaction solution was then transferred to acetic anhydride (290.35 g, 2.84 mol) dissolved in anhydrous tetrahydrofuran (1 L) via double-headed needle. Subsequently, the reaction solution was transferred to acetic anhydride (290.35 g, 2.84 mol) dissolved in anhydrous tetrahydrofuran (1 L) via a double-ended needle at the same temperature. After addition, the reaction mixture was stirred at -70 °C for 1 h, followed by natural warming to room temperature. The reaction mixture was poured into ice (5 L), stirred thoroughly and allowed to stand at room temperature overnight. The aqueous phase was extracted with ether (3 x 1.5 L), and the organic phase was combined and washed sequentially with water (3 x 750 mL), saturated sodium bicarbonate solution (3 x 750 mL) and brine (1 x 750 mL). The organic phase was dried over anhydrous magnesium sulfate, filtered and concentrated to obtain a yellow liquid crude product. The crude product was placed in a hot water bath and the residual 1,2-dichlorobenzene and acetic anhydride were removed under high vacuum to finally obtain 2,3-dichloroacetophenone (67.2 g, 75% yield). The product was analyzed by infrared spectroscopy (IR), nuclear magnetic resonance (NMR) and thin-layer chromatography (TLC, silica gel plate, the unfolding agent was chloroform), the product was of high purity and contained only a small amount of impurities, so it was not further purified.

References

[1] Patent: US5912345, 1999, A
[2] Patent: US5925755, 1999, A

2,3-Dichloroacetophenone Preparation Products And Raw materials

Raw materials

2,3-Dichloro-α-methylbenzenemethanol 1,2-Dichlorobenzene Tetrahydrofuran n-Butyllithium Hexane
Acetic anhydride

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Preparation Products

2,3-Dichloroacetophenone Suppliers

Global( 166)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
Changzhou Ansciep Chemical Co., Ltd. 		+86 519 86305871 sales@ansciepchem.com CHINA 4241 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10405 58
Changzhou Ditong Chemical Co.,Ltd 		+86-0519-88298848 info@edengenechem.com China 2176 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Wuhan Chemwish Technology Co., Ltd 		027-67849912 sales@chemwish.com CHINA 10821 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49977 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29795 58
Fuxin Pharmaceutical 		+86-021-021-50872116 +8613122107989 contact@fuxinpharm.com China 9983 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
Changzhou Ansciep Chemical Co., Ltd. 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
Changzhou Ditong Chemical Co.,Ltd 		58
Alchem Pharmtech,Inc. 		58
Wuhan Chemwish Technology Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
Fuxin Pharmaceutical 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58

View Lastest Price from 2,3-Dichloroacetophenone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,3-Dichloroacetophenone pictures 2020-01-10 2,3-Dichloroacetophenone
56041-57-7
 US $1.00 / KG 1KG 99% 200kg Career Henan Chemical Co

2,3-Dichloroacetophenone Spectrum

2,3-Dichloroacetophenone(56041-57-7)1HNMR2,3-Dichloroacetophenone(56041-57-7)FT-IR

56041-57-7(2,3-Dichloroacetophenone)Related Search:

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2,3-Dichloroacetophenone 1-(2,3-DICHLOROPHENYL)ETHAN-1-ONE Ethanone,1-(2,3-dichlorophenyl)- 2',3'-Dichloroacetophenone 1-(2,3-Dichlorophenyl)ethanone Ketoconazole Impurity 47 2′,3′-Dichloroacetophenone, CAS 56041-57-7 56041-57-7 56041-87-7 C8H6Cl2O Aromatic Acetophenones & Derivatives (substituted)