Tebufelone
- CAS No.
- 112018-00-5
- Chemical Name:
- Tebufelone
- Synonyms
- NE-11740;Tebufelone;Tebufelone, 10 mM in DMSO;1-(3,5-Ditert-butyl-4-hydroxyphenyl)-5-hexyn-1-one;5-Hexyn-1-one, 1-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-
- CBNumber:
- CB51117793
- Molecular Formula:
- C20H28O2
- Molecular Weight:
- 300.44
- MDL Number:
- MFCD00864365
- MOL File:
- 112018-00-5.mol
| form | Solid |
|---|---|
| color | White to off-white |
| FDA UNII | O048K9ZFHO |
Tebufelone Chemical Properties,Uses,Production
Uses
Tebufelone (NE-11740), a nonsteroidal anti-inflammatory drug (NSAID), is a selective dual COX-2/5-lipoxygenase inhibitor. Tebufelone displays potent anti-inflammatory, analgesic and anti-pyretic properties[1][2].
IC 50
COX-2; 5-LO
References
[1] S M Weisman, et al. Effects of tebufelone (NE-11740), a new anti-inflammatory drug, on arachidonic acid metabolism. Agents Actions. 1994 May;41(3-4):156-63. DOI:10.1007/BF02001910
[2] Sebastian Braun, et al. Carborane-Based Tebufelone Analogs and Their Biological Evaluation In Vitro. ChemMedChem. 2023 Jul 17;18(14):e202300206. DOI:10.1002/cmdc.202300206
Tebufelone Preparation Products And Raw materials
Raw materials
Preparation Products
Tebufelone Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| Changzhou Bojia Biomedical Technology Co., Ltd. | 2122619822 | czbjpharma@126.com | China | 18478 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9835 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 19938 | 58 |
| Sangon Biotech (Shanghai) Co.,Ltd. | 400-821-026 | Sales@sangon.com | China | 48813 | 58 |