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Caspofungin acetate

Caspofungin acetate structure

CAS No.: 179463-17-3

Chemical Name:: Caspofungin acetate

Synonyms: Cancidas;Caspofungin Diacetate;(3S,6S,9S,11R,15S,18S,20R,21S,24S,25S)-21-(2-Aminoethylamino)-3-[3-amino-1(R)-hydroxypropyl]-6-[1(S),2(S)-dihydroxy-2-(4-hydroxyphenyl)ethyl]-18-(10,12-dimethyltetradecanamido)-11,20,25-trihydroxy-15-[1(R)-hydroxyethyl]-1,4,7,13,16,22-hexaazatricyclo[22.3.0.0(9,13)]heptacosane-2,5,8,14,17,23-hexaone diacetate;Mk0991;Mk 0991;L 743872;L-743872;L 743873;L-743,872;L 743,872

CBNumber:: CB51120146

Molecular Formula:: C54H92N10O17

Molecular Weight:: 1153.38

MDL Number:: MFCD08141839

MOL File:: 179463-17-3.mol

MSDS File:: SDS

Last updated:2023-11-13 16:15:56

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Caspofungin acetate Properties

Melting point	>105°C (dec.)
storage temp.	-20°C
solubility	H2O: soluble15mg/mL (clear solution)
form	powder
color	white to beige
InChIKey	OGUJBRYAAJYXQP-LLXMLGLCSA-N
FDA UNII	VUW370O5QE
NCI Dictionary of Cancer Terms	caspofungin acetate
NCI Drug Dictionary	Cancidas

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H317-H319-H335

Precautionary statements

P261-P280-P305+P351+P338

WGK Germany

RTECS

TP8046500

NFPA 704

	0
3		0

Caspofungin acetate price More Price(50)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML0425	Caspofungin diacetate ≥97% (HPLC)	179463-17-3	5mg	$112	2024-03-01	Buy
Sigma-Aldrich	SML0425	Caspofungin diacetate ≥97% (HPLC)	179463-17-3	25mg	$451	2024-03-01	Buy
Cayman Chemical	15923	Caspofungin (acetate) ≥98%	179463-17-3	1mg	$32	2024-03-01	Buy
Cayman Chemical	15923	Caspofungin (acetate) ≥98%	179463-17-3	5mg	$86	2024-03-01	Buy
Cayman Chemical	15923	Caspofungin (acetate) ≥98%	179463-17-3	10mg	$153	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML0425	5mg	$112	Buy
SML0425	25mg	$451	Buy
15923	1mg	$32	Buy
15923	5mg	$86	Buy
15923	10mg	$153	Buy

Caspofungin acetate Chemical Properties,Uses,Production

Description

Caspofungin is the first in a new class of antifungal agents named echinocandin to be launched in the US for the parenteral treatment of invasive aspergillosis in patients refractory to, or intolerant of other antifungal therapies such as amphotericin-B₁ lipid formulation of amphotericin-B and/or itraconazole. Caspofungin is a water soluble, stable, aza-substituted semisynthetic derivative of pneumocandin B, a fermentation product of the fungus Zalerion arboricola. Since fungi and humans are both eukaryotes, new antifungal agents must focus on fungus-specific targets in order to minimize potential toxicity in the human host. In this respect, the lipopeptide caspofungin, inhibits the synthesis of 1,3-beta- D-glucans present only in the fungal cell wall, which leads to the specific lysis of the pathogenic cells. The compound is fungicidal rather than fungistatic, an unusual feature among antifungal agents. Caspofungin has activity in vitro and in vivo against a range of Candida species (including azole and amphotericin B resistant Candida) and also against Aspergillus, an important pathogen which is not susceptible to fluconazole. Caspofungin was generally more active than amphotericin B, flucytosine, fluconazole and itraconazole against Candida species. Cryptococcus is not susceptible to caspofungin. Caspofungin has a half-life in human beings around 10 hours. Unlike the azoles, caspofungin does not inhibit cytochrome P450. The drug has been given intravenously with loading dose of 70 rag, followed by 50 mg daily to be effective in invasive aspergillosis refractory to prior antifungal therapy. Most of the side effects were mild and comprised fever, thrombophlebitis, headache, nausea, rash and flushing.

Description

Caspofungin is an antifungal compound that is classified as an echinocandin, as it acts by noncompetititvely inhibiting the enzyme 1,3-β glucan synthase and preventing the synthesis of glucan in the fungal cell wall. It is effective against disseminated or invasive aspergillosis and candidiasis in mice. Caspofungin has a 50% minimum effective concentration against Aspergillus spp. of 0.015 μg/ml. It does not antagonize other antifungal compounds, like amphotericin B, and, in some cases, may show additive or synergistic activity.

Chemical Properties

White Solid

Originator

Merck & Co (US)

Uses

Calcium antagonist, coronary vasodilator, anti-inflammatory, analgesic

Uses

Caspofungin Diacetate is an impurity of Caspofungin Acetate(C184900) which is an echinocandin that inhibits the synthesis of β (1,3)-D-glucan, an integral component of the fungal cell wall. An antifungal drug used in the treatment of invasive fungal infections.

Uses

Caspofungin acetate is a semi-synthetic analogue of pneumocandin B0 with improved water solubility, a significant limitation in the development of the echinocandin class as pharmaceuticals. Caspofungin acetate acts by inhibiting the synthesis of β-(1,3)-D-glucan, an essential component of the cell wall of susceptible fungi.

Definition

ChEBI: The diacetate salt of caspofungin. It is used for the treatment of invasive candidiasis, and of aspergillosis in patients who are refractory to, or intolerant of, other therapy.

brand name

Cancidas (Merck).

Biochem/physiol Actions

Caspofungin is an echinocandin antifungal that inhibits 1,3-β-D-glucan synthase, which is required for cell wall synthesis, thereby disturbing the integrity of the fungal cell wall.

Veterinary Drugs and Treatments

Caspofungin has potential for treating invasive aspergillosis or disseminated candidal infections in companion animals although little, if any, information on its use in dogs or cats is available.

Caspofungin acetate Preparation Products And Raw materials

Raw materials

Preparation Products

Caspofungin acetate Suppliers

Global( 343)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5993	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2503	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	11013	58
Shaanxi Haibo Biotechnology Co., Ltd	+undefined18602966907	qinhe02@xaltbio.com	China	1000	58
Alpha Biopharmaceuticals Co., Ltd	+86-411-39042497 +8613921981412	sales@alphabiopharm.com	China	886	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60

Supplier	Advantage
Hebei Yanxi Chemical Co., Ltd.	58
Henan Bao Enluo International TradeCo.，LTD	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
Shaanxi Haibo Biotechnology Co., Ltd	58
Alpha Biopharmaceuticals Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Yingrui Biopharma Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60

View Lastest Price from Caspofungin acetate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-17	Caspofungin acetate 179463-17-3	US $1.10 / g	1g	99.0% min	100 tons min	Shaanxi Dideu Medichem Co. Ltd
2024-04-12	Caspofungin Acetate 179463-17-3	US $0.00 / kg	1kg	99%	2000ton	Shaanxi Haibo Biotechnology Co., Ltd
2024-01-08	Caspofungin acetate 179463-17-3	US $500.00 / KG	10KG	99.50%	1000kg	Wuhan Boyuan Import & Export Co., LTD

Caspofungin acetate
179463-17-3
US $1.10 / g
99.0% min
Shaanxi Dideu Medichem Co. Ltd

Caspofungin Acetate
179463-17-3
US $0.00 / kg
99%
Shaanxi Haibo Biotechnology Co., Ltd

Caspofungin acetate
179463-17-3
US $500.00 / KG
99.50%
Wuhan Boyuan Import & Export Co., LTD

Caspofungin acetate Spectrum

Caspofungin acetate(179463-17-3)MS

179463-17-3(Caspofungin acetate)Related Search:

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Caspofungin Vinyl acetate ACETATE Caspofungin acetate

1of3

Caspofungin acetate Caspofungin acetate [USAN:BAN:JAN] L 743,872 L 743872 L-743,872 L-743872 Mk 0991 Mk0991 Pneumocandin B0, 1-((4R,5S)-5-((2-aminoethyl)amino)-N2-(10,12-dimethyl-1-oxotetradecyl)-4-hydroxy-L-ornithine)-5-((3R)-3-hydroxy-L-ornithine)-, diacetate (salt) 1-[(4R,5S)-5-[(2-AMinoethyl)aMino]-N2-[(10R,12S)-10,12-diMethyl-1-oxotetradecyl]-4-hydroxy-L-ornithine]-5-(threo-3-hydroxy-L-ornithine)pneuMocandin B0 Diacetate 1-[(4R,5S)-5-[(2-AMinoethyl)aMino]-N2-[(10R,12S)-10,12-diMethyl-1-oxotetradecyl]-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]pneuMocandin B0 Diacetate L 743873 Cancidas, L-743,872, MK-0991 Cancidas (Caspofungin Acetate) Pneumocandin B0, 1-[(4R,5S)-5-[(2-aminoethyl)amino]-N2-[(10R,12S)-10,12-dimethyl-1-oxotetradecyl]-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-, acetate (1:2) (3S,6S,9S,11R,15S,18S,20R,21S,24S,25S)-21-(2-Aminoethylamino)-3-[3-amino-1(R)-hydroxypropyl]-6-[1(S),2(S)-dihydroxy-2-(4-hydroxyphenyl)ethyl]-18-(10,12-dimethyltetradecanamido)-11,20,25-trihydroxy-15-[1(R)-hydroxyethyl]-1 Caspofungin acetate Cancidas 1-[(4R,5S)-5-[(2-Aminoethyl)amino]-N2-(10,12-dimethyl-1-oxotetradecyl)-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-pneumocandin B0 Caspofungin diacetate, >=98% Casp ungin Acetate Caspofungin Acetate (L 743872 Caspofungin Acetate for lnjection Cancidas, ≥98% Casporfungin Acetate CF/KB(EUGMP,GMP) L 743872;L 743873;MK 0991;MK-0991 Caspofungin acetate USP/EP/BP Caspofungin diacetate salt Caspofungin acetate B0 pofungin Acetate (10R,12S)-N-((2R,6S,9S,11R,12S,14aS,15S,20S,23S,25aS)-20-((R)-3-Amino-1-hydroxypropyl)-12-((2-aminoethyl)amino)-23-((1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl)-2,11,15-trihydroxy-6-((R)-1-hydroxyethyl)-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl)-10,12-dimethyltetradecanamide diacetate Caspofungin Acetate (MK0991) (10R,12S)-N-((2R,6S,9S,11R,12S,14aS,15S,20S,23S,25aS)-20-((R)-3-Amino-1-hydroxypropyl)-12-((2-aminoethyl)amino)-23-((1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl)-2,11,15-trihydroxy-6-((R)-1-hydroxyethyl)-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrol US-DMF No.: 034091 ASMF Approved Caspofungin Diacetate Cancidas (3S,6S,9S,11R,15S,18S,20R,21S,24S,25S)-21-(2-Aminoethylamino)-3-[3-amino-1(R)-hydroxypropyl]-6-[1(S),2(S)-dihydroxy-2-(4-hydroxyphenyl)ethyl]-18-(10,12-dimethyltetradecanamido)-11,20,25-trihydroxy-15-[1(R)-hydroxyethyl]-1,4,7,13,16,22-hexaazatricyclo[22.3.0.0(9,13)]heptacosane-2,5,8,14,17,23-hexaone diacetate Bamifylline Impurity 2 Caspofungin Acetate (>90%) Carpofungin acetate Gaspofungin Acetate (10R,12S)-N-((2R,6S,9S,11R,12S,14aS,15S,20S,23S,25aS)-20-((R)-3-amino-1-hydroxypropyl)-12-((2-aminoethyl)amino)-23-((1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl)-2,11,15-trihydroxy-6-((R)-1-hydroxyethyl)-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl)-10,12-dimethyltetradecanamide acetate (10R,12S)-N-((2R,6S,9S,11R,12S,14aS,15S,20S,23S,25aS)-20-((R)-3-Amino-1-hydroxypropyl)-12-((2-aminoethyl)amino)-23-((1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl)-2,11,15-trihydroxy-6-((R)-1-hydroxyethyl)-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl)-10,12-dimethyltetradecanamide diacetate 179463-17-3 179643-17-3 79463-17-3 C56H96N10O19 C52H88N10O152C2H4O2 API Amines Heterocycles Inhibitors Intermediates & Fine Chemicals Pharmaceuticals