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(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol

Uses Preparation
(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol structure
CAS No.
127852-28-2
Chemical Name:
(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
Synonyms
R-MBT-PEL;Aprepitant Impurity 49;Rolapitant Intermediate 3;Fosaprepitant Impurity 25;(R)-BIS-3,5-TRIFLUOROMETHYL-1-PHENYLETHANOL;(R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHANOL;(R)-1-[BIS-3,5-(TRIFLUOROMETHYL)PHENYL]ETHANOL;(1R)-1-[3,6-BIS(TRIFLUOROMETHYL)PHENYL]ETHANOL;(R)-1-(3,5-BIS(TRIFLUOROMETHYL)PHENYL)ETHAN-1-OL;(R)-1-[3,5-BIS(TRIFLUORO-METHYL)-PHENYL]ETHANOL 98%
CBNumber:
CB5113482
Molecular Formula:
C10H8F6O
Formula Weight:
258.16
MOL File:
127852-28-2.mol

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol Properties

Melting point:
53-58℃
Boiling point:
175.8±35.0 °C(Predicted)
Density 
1.376±0.06 g/cm3(Predicted)
form 
Powder
pka
13.99±0.20(Predicted)
color 
White
optical activity
[α]/D +27±1°, c = 1 in acetonitrile
λmax
272nm(MeOH)(lit.)
InChIKey
MMSCIQKQJVBPIR-RXMQYKEDSA-N
CAS DataBase Reference
127852-28-2(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H302-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-52/53-22
Safety Statements  26-36/37/39-61
WGK Germany  3
Hazard Note  Irritant
HS Code  29062990

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 49554 (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol ≥98.0% (GC) 127852-28-2 5g $79.4 2019-12-02 Buy
Sigma-Aldrich 49554 (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol ≥98.0% (GC) 127852-28-2 25g $349 2019-12-02 Buy
TCI Chemical B4131 (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol >98.0%(GC) 127852-28-2 5g $71 2020-06-24 Buy
TCI Chemical B4131 (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol >98.0%(GC) 127852-28-2 25g $234 2020-06-24 Buy
Alfa Aesar H60893 (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol, 98% 127852-28-2 5g $61.6 2020-06-24 Buy

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol Chemical Properties,Uses,Production

Uses

(R)-[3,5-bis (trifluoromethyl) phenyl] ethanol is an important chiral intermediate for the synthesis of novel chemotherapeutic and antiemetic drugs NK-1 receptor antagonists. Antidepressants have good potential efficacy in treating a range of central and peripheral nervous system depressions.

Preparation

At present, the methods for preparing optically pure (R)-[3,5-bis (trifluoromethyl) phenyl] ethanol include chemical methods and biological methods. Chemical synthesis requires the use of expensive transition metal Ru and other chemical catalysts, complicated steps, harsh reaction conditions, high energy consumption, large pollution, and low yield. Biological law is the use of free enzymes or whole cells for catalytic preparation. It has the characteristics of mild reaction conditions, high catalytic efficiency, and strong specificity.

Chemical Properties

White fine crystalline powder

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol Preparation Products And Raw materials

Raw materials

Preparation Products


(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol Suppliers

Global( 257)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shanghai Yingrui Biopharma Co.,Ltd
+86-21-33585366
+86-21-34979012 export01@shyrchem.com CHINA 1321 58
Zhuozhou Wenxi import and Export Co., Ltd
+8613111626072
+8613111626072 zzwenxi@126.com CHINA 7497 58
Frapp's ChemicalNFTZ Co., Ltd.
+86 (576) 8169-6106
+86 (576) 8169-6105 sales@frappschem.com China 886 50
Capot Chemical Co.,Ltd.
+86-571-85586718
+86-571-85864795 sales@capotchem.com China 19929 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21821 58
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22626 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 739 60
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24723 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30045 58

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View Lastest Price from (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-02-02 (R)-1-(3,5-Bis-Trifluoromethyl-Phenyl)-Ethanol
127852-28-2
US $180.00 / KG 1KG 97% 1ton Zhuozhou Wenxi import and Export Co., Ltd
2019-10-22 (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
127852-28-2
US $95.00 / KG 10g 99% 20tons Hebei shuoxi biotechnology co. LTD
2018-07-25 (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
127852-28-2
US $100.00 / KG 1KG 99% 10KG,20KG career henan chemical co

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