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4-Methoxyphenylacetic acid

Description Reference
4-Methoxyphenylacetic acid
4-Methoxyphenylacetic acid structure
Chemical Name:
4-Methoxyphenylacetic acid
ASISCHEM D13364;HOMOANISIC ACID;HOMO-P-ANISIC ACID;p-Anisylacetic acid;RARECHEM AL BO 0133;4-Methoxyphenylaceti;p-Methioxy-toluicacid;4-Methoxyphenylacetic;2-(p-anisyl)aceticacid;LABOTEST-BB LT00848110
Molecular Formula:
Formula Weight:
MOL File:

4-Methoxyphenylacetic acid Properties

Melting point:
84-86 °C(lit.)
Boiling point:
140 °C3 mm Hg(lit.)
1.1708 (rough estimate)
refractive index 
1.5101 (estimate)
Flash point:
storage temp. 
Store below +30°C.
pK1:4.358 (25°C)
Crystalline Powder and Chunks
White to light yellow
Water Solubility 
6 g/L (20 ºC)
CAS DataBase Reference
104-01-8(CAS DataBase Reference)
NIST Chemistry Reference
Benzeneacetic acid, 4-methoxy-(104-01-8)
EPA Substance Registry System
Benzeneacetic acid, 4-methoxy-(104-01-8)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38-20/21/22
Safety Statements  26-36
WGK Germany  3
RTECS  AI8960000
Hazard Note  Irritant
HS Code  29189090
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger P280, P305+P351+P338, P310
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.
P501 Dispose of contents/container to..…

4-Methoxyphenylacetic acid price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich M19201 4-Methoxyphenylacetic acid ReagentPlus , 99% 104-01-8 100g $32.8 2018-11-13 Buy
Sigma-Aldrich M19201 4-Methoxyphenylacetic acid ReagentPlus , 99% 104-01-8 5g $18.7 2018-11-13 Buy
TCI Chemical M0742 4-Methoxyphenylacetic Acid >98.0%(GC)(T) 104-01-8 25g $19 2018-11-22 Buy
TCI Chemical M0742 4-Methoxyphenylacetic Acid >98.0%(GC)(T) 104-01-8 100g $37 2018-11-22 Buy
Alfa Aesar A14399 4-Methoxyphenylacetic acid, 98+% 104-01-8 100g $32.7 2018-11-13 Buy

4-Methoxyphenylacetic acid Chemical Properties,Uses,Production


4-METHOXYPHENYLACETIC ACID(104-01-8) is used in organic synthesis as well as pharmaceutical industry, especially used as an intermediate of puerarin. It can also be used as potential plasma biomarkers for early detection of non-small cell lung cancer. It is also used in drug industry as an intermediate to make Dextromethorphan.


Chen, Yan Ping, Y. M. Chen, and M. Tang. "Solubilities of cinnamic acid, phenoxyacetic acid and 4-methoxyphenylacetic acid in supercritical carbon dioxide." Fluid Phase Equilibria 275.1(2008):33-38.

Chemical Properties

white to light yellow crystalline powder and


Preparation of pharmaceuticals, other organic compounds.


ChEBI: A monocarboxylic acid that is phenylacetic acid carrying a 4-methoxy substituent. It is used as an intermediate for pharmaceuticals and other organic synthesis. It has been found to inhibit the germination of cress and lettuce seeds.

General Description

Pale yellow or off white colored flakes. Severely irritates skin and eyes. May be toxic by ingestion.

Reactivity Profile

Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in water; those with more than six carbons are slightly soluble in water. Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions. The pH of solutions of carboxylic acids is therefore less than 7.0. Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry. Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in 4-Methoxyphenylacetic acid to corrode or dissolve iron, steel, and aluminum parts and containers. Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide. The reaction is slower for dry, solid carboxylic acids. Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide. Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat. Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat. A wide variety of products is possible. Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions.

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.

Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. Questionable carcinogen with experimental neoplastigenic data. When heated to decomposition it emits acrid smoke and irritating fumes.

Purification Methods

Crystallise the acid from EtOH/water, EtOAc/pet ether (m 87o) or *C6H6/pet ether (m 84-86o). [Beilstein 10 III 431, 10 IV 544.] The acid chloride [4693-91-8] has M 184.6, b 143o/10mm, d 254

4-Methoxyphenylacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

4-Methoxyphenylacetic acid Suppliers

Global( 309)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 China 19954 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 22043 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20786 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32651 55
Chemwill Asia Co.,Ltd.
86-21-51861608;;; CHINA 24118 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254 CHINA 20243 58
Accela ChemBio Inc.
(+1)-858-876-1948 United States 12156 58
career henan chemical co
+86-371-86658258 CHINA 19997 58
MINKESH (SHANGHAI) CO., LTD. +86 021 20983811 13167252998
+86 021 23027795 China 57 55
Shanghai Boyle Chemical Co., Ltd. Mr Qiu:021-50182298(Demestic market) Miss Xu:021-50180596(Abroad market)
+86-21-57758967 China 2220 55

View Lastest Price from 4-Methoxyphenylacetic acid manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-14 4-Methoxyphenylacetic acid
US $1.00 / kg 1kg as customer's need 100kg career henan chemical co

4-Methoxyphenylacetic acid Spectrum

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