N-(n-Nonyl)deoxynojirimycin
- CAS No.
- 81117-35-3
- Chemical Name:
- N-(n-Nonyl)deoxynojirimycin
- Synonyms
- Nonyl-DNJ;N-Nonyldeoxynojirimycin;N-(n-Nonyl)-1-deoxynojirimycin;N-(n-Nonyl)-1-deoxynojirimycin min. 99%;(2R,3R,4R,5S)-2-(Hydroxymethyl)-1-nonyl-3,4,5-piperidinetriol;(2R,3R,4R,5S)-2-(hydroxymethyl)-1-nonylpiperidine-3,4,5-triol;3,4,5-Piperidinetriol, 2-(hydroxymethyl)-1-nonyl-, (2R,3R,4R,5S)-
- CBNumber:
- CB51176507
- Molecular Formula:
- C15H31NO4
- Molecular Weight:
- 289.41
- MDL Number:
- MFCD00905846
- MOL File:
- 81117-35-3.mol
- MSDS File:
- SDS
N-(n-Nonyl)deoxynojirimycin price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | N6414 | NN-DNJ ≥98% (HPLC) | 81117-35-3 | 5mg | $229 | 2024-03-01 | Buy |
| Sigma-Aldrich | N6414 | NN-DNJ ≥98% (HPLC) | 81117-35-3 | 25mg | $880 | 2024-03-01 | Buy |
| Cayman Chemical | 29698 | N-Nonyldeoxynojirimycin | 81117-35-3 | 1mg | $36 | 2024-03-01 | Buy |
| Cayman Chemical | 29698 | N-Nonyldeoxynojirimycin | 81117-35-3 | 25mg | $469 | 2024-03-01 | Buy |
| Cayman Chemical | 29698 | N-Nonyldeoxynojirimycin | 81117-35-3 | 5mg | $155 | 2024-03-01 | Buy |
N-(n-Nonyl)deoxynojirimycin Chemical Properties,Uses,Production
Chemical Properties
White Crystalline Solid
Definition
ChEBI: N-nonyldeoxynojirimycin is a hydroxypiperidine that is deoxynojirimycin (duvoglustat) in which the amino hydrogen is replaced by a nonyl group. It has a role as an EC 3.2.1.45 (glucosylceramidase) inhibitor, an EC 3.2.1.20 (alpha-glucosidase) inhibitor and an antiviral agent. It is a hydroxypiperidine and a tertiary amino compound. It is functionally related to a duvoglustat.
Biological Activity
Glucosidase inhibitor (IC 50 values are 0.42 and 8.4 μ M for acid α -glucosidase and α -1,6-glucosidase respectively). Inhibits liver glycogen breakdown in vivo . Also acts as a chemical chaperone; chaperones β -Glu folding at neutral p.H. allowing the stabilized enzyme to transit from the endoplasmic reticulum to the golgi, enabling proper trafficking to the lysosome.
Biochem/physiol Actions
NN-DNJ is a glucosidase inhibitor that acts as a pharmacologic chaperone. NN-DNJ also acts synergistically with proteostasis modulators such as celastrol and MG132 to stabilize mutant proteins in properly folded states. NN-DNJ stabilizes various proteins against misfolding, increasing proper trafficking from the endoplasmic reticulum. There is potential use in studying diseases marked by misfolded proteins and has shown antiviral activity.
storage
Store at -20°C
N-(n-Nonyl)deoxynojirimycin Preparation Products And Raw materials
Raw materials
Preparation Products
N-(n-Nonyl)deoxynojirimycin Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Creative Peptides | info@creative-peptides.com | United States | 6084 | 56 | |
| Aikon International Limited | 025-58851090 13611564524 | lwan@aikonchem.com | China | 15952 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55717 | 58 |