ChemicalBook >> CAS DataBase List >>Nitecapone
Nitecapone
- CAS No.
- 116313-94-1
- Chemical Name:
- Nitecapone
- Synonyms
- OR 462;Nitecapone;3-(3,4-dihydroxy-5-nitrobenzylidene)pentane-2,5-dione;3-(3,4-Dihydroxy-5-nitrobenzylidene)pentane-2,4-dione;3-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-2,4-pentanedione;2,4-Pentanedione, 3-[(3,4-dihydroxy-5-nitrophenyl)methylene]-;GSH,Nitecapone,glutathione,OR-462,Inhibitor,ROS,Parkinson,COMT,OR 462,inhibit,OR462,allodynia
- CBNumber:
- CB51176592
- Molecular Formula:
- C12H11NO6
- Molecular Weight:
- 265.22
- MDL Number:
- MFCD00866318
- MOL File:
- 116313-94-1.mol
- MSDS File:
- SDS
Last updated:2023-07-12 16:59:56
| Melting point | 171-173°C |
|---|---|
| Boiling point | 495.3±45.0 °C(Predicted) |
| Density | 1.451±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | DMSO: soluble15mg/mL, clear |
| form | powder |
| pka | 5.60±0.50(Predicted) |
| color | white to beige |
| FDA UNII | 98BS722498 |
Nitecapone price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0671 | Nitecapone ≥98% (HPLC) | 116313-94-1 | 5mg | $73.2 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0671 | Nitecapone ≥98% (HPLC) | 116313-94-1 | 25mg | $354 | 2024-03-01 | Buy |
| Cayman Chemical | 18656 | Nitecapone ≥98% | 116313-94-1 | 5mg | $73 | 2024-03-01 | Buy |
| Cayman Chemical | 18656 | Nitecapone ≥98% | 116313-94-1 | 10mg | $138 | 2024-03-01 | Buy |
| Cayman Chemical | 18656 | Nitecapone ≥98% | 116313-94-1 | 25mg | $288 | 2024-03-01 | Buy |
Nitecapone Chemical Properties,Uses,Production
Description
Nitecapone (OR-462) is a drug which acts as a selective inhibitor of the enzyme catechol O-methyl transferase (COMT).It was patented as an antiparkinson medication.
In vitro
Nitecapone (1-100 μM) reducesd GSH (reduced glutathione) depletion induced by ROO-by 11-38% and oxidation to oxidized glutathione (GSSG) by 32-45%.MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Biological activity
Nitecapone (OR-462) is a short-acting, orally active, catechol-O-methyltransferase (COMT) inhibitor with gastrointestinal protective and antioxidant activity. Nitecapone (OR-462) scavenges reactive oxygen species and nitric oxide and prevents lipid peroxidation.
Chemical Properties
Yellow Solid
Uses
Inhibitor for the treatment of Parkinson disease
Uses
Inhibitor for the treatment of Parkinson's disease.
Definition
ChEBI: Nitecapone is a hydroxycinnamic acid.
Nitecapone Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 51)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
View Lastest Price from Nitecapone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-02-02 | Nitecapone
116313-94-1
|
US $1.00 / g | 1g | 99% | 200g | Career Henan Chemical Co |
-
- Nitecapone
116313-94-1
- US $1.00 / g
- 99%
- Career Henan Chemical Co
116313-94-1(Nitecapone)Related Search:
3-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-2,4-pentanedione
Nitecapone
OR 462
3-(3,4-Dihydroxy-5-nitrobenzylidene)pentane-2,4-dione
3-(3,4-dihydroxy-5-nitrobenzylidene)pentane-2,5-dione
GSH,Nitecapone,glutathione,OR-462,Inhibitor,ROS,Parkinson,COMT,OR 462,inhibit,OR462,allodynia
2,4-Pentanedione, 3-[(3,4-dihydroxy-5-nitrophenyl)methylene]-
116313-94-1
Intermediates & Fine Chemicals
Pharmaceuticals
Aromatics