ChemicalBook >> CAS DataBase List >>Telatinib

Telatinib

CAS No.
332012-40-5
Chemical Name:
Telatinib
Synonyms
CS-361;CS-1854;Telatnib;Bay 57-9352;Unii-18p7197Q7j;Telatinib USP/EP/BP;Telatinib(BAY 57-9352);4-((4-(4-chlorophenylamino)furo[2,3-d]pyridazin-7-yloxy)methyl)-N-methylpicolinamide;4-[[4-(4-Chloroanilino)furo[2,3-d]pyridazin-7-yl]oxymethyl]-N-methyl-pyridine-2-carboxamide;4-[[[4-[(4-Chlorophenyl)amino]furo[2,3-d]pyridazin-7-yl]oxy]methyl]-N-methyl-2-pyridinecarboxamide
CBNumber:
CB51179861
Molecular Formula:
C20H16ClN5O3
Molecular Weight:
409.83
MDL Number:
MFCD18251453
MOL File:
332012-40-5.mol
MSDS File:
SDS
Last updated:2023-06-08 09:03:09

Telatinib Properties

Boiling point 713.6±60.0 °C(Predicted)
Density 1.417
storage temp. Store at -20°C
solubility insoluble in H2O; insoluble in EtOH; ≥20.5 mg/mL in DMSO
form solid
pka 14.18±0.46(Predicted)
FDA UNII 18P7197Q7J

SAFETY

Risk and Safety Statements

Telatinib price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 26203 Telatinib 332012-40-5 5mg $98 2024-03-01 Buy
Cayman Chemical 26203 Telatinib 332012-40-5 50mg $728 2024-03-01 Buy
Cayman Chemical 26203 Telatinib 332012-40-5 10mg $167 2024-03-01 Buy
Cayman Chemical 26203 Telatinib 332012-40-5 25mg $389 2024-03-01 Buy
TRC T015700 Telatinib 332012-40-5 10mg $145 2021-12-16 Buy
Product number Packaging Price Buy
26203 5mg $98 Buy
26203 50mg $728 Buy
26203 10mg $167 Buy
26203 25mg $389 Buy
T015700 10mg $145 Buy

Telatinib Chemical Properties,Uses,Production

Description

Telatinib is a multi-kinase inhibitor that inhibits VEGF receptor 2 (VEGFR2), VEGFR3, PDGFRα, and c-Kit (IC50s = 6, 4, 15, and 1 nM, respectively). It also binds to the transmembrane region of the ABCG2 efflux transporter and enhances intracellular accumulation of [3H]-mitoxantrone in ABCG2-overexpressing cells. Telatinib (15 mg/kg) decreases tumor growth rate and size in an H460/MX20 mouse xenograft model.

Uses

Telatinib small-molecule inhibitor of vascular endothelial growth factor receptors 2 and 3 (VEGFR-2/-3) and platelet-derived growth factor receptor β tyrosine kinases. Telatinib is used therapeutically in patients with advanced solid tumors.

Uses

Telatinib small-molecule inhibitor of vascular endothelial growth factor receptors 2 and 3 (VEGFR-2/-3) and platelet-derived growth factor receptor β tyrosine kinases. Telatinib is used therapeuticall y in patients with advanced solid tumors.

Uses

Telatinib (BAY 57-9352) is an orally available, potent multitargeted VEGFR-2, VEGFR-3, PDGFR-β and c-Kit tyrosine kinases inhibitor with an IC50 of 19 nM for the inhibition of VEGFR-2 autophosphorylation.

target

c-Kit

References

[1]. steeghs, n., et al., hypertension and rarefaction during treatment with telatinib, a small molecule angiogenesis inhibitor. clin cancer res, 2008. 14(11): p. 3470-6.
[2]. strumberg, d., et al., phase i dose escalation study of telatinib (bay 57-9352) in patients with advanced solid tumours. br j cancer, 2008. 99(10): p. 1579-85.
[3]. sodani, k., et al., telatinib reverses chemotherapeutic multidrug resistance mediated by abcg2 efflux transporter in vitro and in vivo. biochem pharmacol, 2014. 89(1): p. 52-61.
[4]. eskens, f.a., et al., phase i dose escalation study of telatinib, a tyrosine kinase inhibitor of vascular endothelial growth factor receptor 2 and 3, platelet-derived growth factor receptor beta, and c-kit, in patients with advanced or metastatic solid tumors. j clin oncol, 2009. 27(25): p. 4169-76.

332013-43-1
332013-40-8
332012-40-5
Synthesis of Telatinib from (2-METHYLAMINOCARBONYL-4-PYRIDYL)METHANOL and Furo[2,3-d]pyridazin-4-amine, 7-chloro-N-(4-chlorophenyl)-
Global( 120)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 29797 60
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60
Biochempartner
0086-13720134139 candy@biochempartner.com CHINA 967 58
Hubei xin bonus chemical co. LTD
86-13657291602 linda@hubeijusheng.com CHINA 22968 58
Alchem Pharmtech,Inc.
8485655694 sales@alchempharmtech.com United States 63711 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 47465 58
Career Henan Chemica Co
+86-0371-86658258 15093356674; laboratory@coreychem.com China 30255 58
ANHUI WITOP BIOTECH CO., LTD
+8615255079626 eric@witopchemical.com China 23556 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250 1026@dideu.com China 29831 58
Sinoway Industrial co., ltd.
0592-5800732; +8613806035118 xie@china-sinoway.com China 990 58

View Lastest Price from Telatinib manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Telatinib USP/EP/BP pictures 2021-07-07 Telatinib USP/EP/BP
332012-40-5
US $1.10 / g 1g 99.9% 100 Tons Min Dideu Industries Group Limited
2-Pyridinecarboxamide, 4-(((4-((4-chlorophenyl)amino)furo(2,3-D)pyridazin-7-yl)oxy)methyl)-N-methyl- Bay 57-9352 Unii-18p7197Q7j Telatinib(BAY 57-9352) 4-[[[4-[(4-Chlorophenyl)amino]furo[2,3-d]pyridazin-7-yl]oxy]methyl]-N-methyl-2-pyridinecarboxamide 4-((4-(4-chlorophenylamino)furo[2,3-d]pyridazin-7-yloxy)methyl)-N-methylpicolinamide 4-[[[4-[(4-Chlorophenyl)amino]furo[2,3-d]pyridazin-7-yl]oxy]methyl]-N-methyl-2-pyridinecarboxamide Telatinib(BAY57-9352) Telatnib 4-[[4-(4-Chloroanilino)furo[2,3-d]pyridazin-7-yl]oxymethyl]-N-methyl-pyridine-2-carboxamide CS-361 CS-1854 Telatinib USP/EP/BP 332012-40-5 API Inhibitors