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Anistreplasa [INN-Spanish]

CAS No.
81669-57-0
Chemical Name:
Anistreplasa [INN-Spanish]
Synonyms
APSAC;Eminase;BRL 26921;Anistreplase;Anistreplasa [INN-Spanish];Anistreplasa [INN-Spanish] USP/EP/BP
CBNumber:
CB51245025
Molecular Formula:
Molecular Weight:
0
MDL Number:
MOL File:
Mol file
Last updated:2022-12-21 16:56:50

Anistreplasa [INN-Spanish] Properties

EWG's Food Scores 1
FDA UNII 5O8V541HJ6
ATC code B01AD03

Anistreplasa [INN-Spanish] Chemical Properties,Uses,Production

Description

APSAC is an anisoylated human plasminogen-streptokinase complex useful in the treatment of myocardial infarct. Its reported advantages over other existing thrombolytics such as alteplase and streptokinase include a longer half life, ease of administration, and a more specific local antithrombotic effect.

Originator

Beecham (United Kingdom)

Uses

Fibrinolytic.

Manufacturing Process

Preparation of freeze dried p-anisoyl streptokinase/plasminogen complex without internal peptide bond cleavages:
Streptokinase (250,000 units, Kabi, Stockholm, Sweden) was dissolved in 0.1 M trishydroxymethylmethane hydrochloride pH 7.4 (2.5 ml) and a solution of 0.1 M p-amidinophenyl p'-anisate in dimethylsulphoxide (0.25 ml) added. A slight cloudiness resulted. To this mixture was added 0.5 ml of a solution of human lys-plasminogen (8.99 mg/ml in the above buffer) [Kabi, Stockholm] and the solution was thoroughly and rapidly mixed. After standing on ice for 15 minutes, the solution was stored on ice until use. After approximaely 2 hours 0.4 ml (40,000 units) of the material was diluted with 3.0 ml of a slurry of L-lysine-sepharose 4B (a 33% wet wt/volume suspension in the above buffer) and stood at 0°C for 1 hour. The gel was filtered on a glass sinter funnel at 4°C under suction and washed with the buffer (100 ml). The gel was eluted under gentle suction with the same buffer containing 0.1 M ε- aminocaproic acid (3 lots of 5 ml). The combined filtrates were dialysed for 2 hours at 4°C against ammonium bicarbonate buffer (50 mM pH 7.0) containing 2.5% w/v mannitol. The product was then freeze dried to 0.799 g of a white solid. Approximately 195 mg of this material was analysed by slab gel polyacrylamide gel electrophoresis using 10% w/v gels in the presence of sodium dodecyl sulphate. Two main polypeptide bands were observed corresponding to lys-plasminogen (m.w. 84,000) and streptokinase (m.w. 47,000). There was also a trace of contaminating human serum albumin derived from the commercial streptokinase preparation.

brand name

Eminase

Therapeutic Function

Thrombolytic

Anistreplasa [INN-Spanish] Preparation Products And Raw materials

Raw materials

Preparation Products

Anistreplasa [INN-Spanish] Suppliers

Global( 5)Suppliers
Supplier Tel Email Country ProdList Advantage
Hubei xin bonus chemical co. LTD
86-13657291602 linda@hubeijusheng.com CHINA 22968 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250 1026@dideu.com China 29831 58
LGM Pharma 1-(800)-881-8210 inquiries@lgmpharma.com United States 2127 70
Beijing HuaMeiHuLiBiological Chemical 010-56205725 waley188@sohu.com China 12338 58
Anistreplasa [INN-Spanish] Anistreplase APSAC BRL 26921 Eminase Anistreplasa [INN-Spanish] USP/EP/BP 81669-57-0