Lasofoxifene
- CAS No.
- 180916-16-9
- Chemical Name:
- Lasofoxifene
- Synonyms
- (5R,6S)-;CP-336,156;Lasofoxifene;Lasofoxifene Base;(5R,6S)-6-phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phenyl]tetralin-2-ol;(5R,6S)-5,6,7,8-Tetrahydro-6-phenyl-5-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-2-naphthalenol;(5R-cis)-5,6,7,8-Tetrahydro-6-phenyl-5-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-2-naphthalenol;(5R,6S)-6-Phenyl-5-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-5,6,7,8-tetrahydronaphthalen-2-ol;2-Naphthalenol, 5,6,7,8-tetrahydro-6-phenyl-5-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-, (5R,6S)-
- CBNumber:
- CB51246956
- Molecular Formula:
- C28H31NO2
- Molecular Weight:
- 413.55
- MDL Number:
- MFCD09475650
- MOL File:
- 180916-16-9.mol
- MSDS File:
- SDS
| Melting point | 110-113°C |
|---|---|
| Boiling point | 572.4±50.0 °C(Predicted) |
| Density | 1.150±0.06 g/cm3(Predicted) |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 10.31±0.60(Predicted) |
| color | White to Off-White |
| FDA UNII | 337G83N988 |
| ATC code | G03XC03 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |     GHS05,GHS07,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H318-H360-H372-H400-H410 | |||||||||
| Precautionary statements | P201-P202-P260-P264-P270-P273-P280-P301+P312-P330-P305+P351+P338-P310-P308+P313-P314-P391-P405-P501 | |||||||||
| NFPA 704 |
|
Lasofoxifene price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21754 | Lasofoxifene ≥98% | 180916-16-9 | 1mg | $121 | 2024-03-01 | Buy |
| Cayman Chemical | 21754 | Lasofoxifene ≥98% | 180916-16-9 | 5mg | $362 | 2024-03-01 | Buy |
| Cayman Chemical | 21754 | Lasofoxifene ≥98% | 180916-16-9 | 10mg | $662 | 2024-03-01 | Buy |
| Cayman Chemical | 21754 | Lasofoxifene ≥98% | 180916-16-9 | 25mg | $1201 | 2024-03-01 | Buy |
| TRC | L176500 | Lasofoxifene | 180916-16-9 | 25mg | $660 | 2021-12-16 | Buy |
Lasofoxifene Chemical Properties,Uses,Production
Chemical Properties
Off-White Solid
Uses
A next-generation selective estrogen receptor modulator for treating disorders associated with increased bone turnover and osteopenia.
Definition
ChEBI: Lasofoxifene is a member of the class of tetralins that is 5,6,7,8-tetrahydronaphthalen-2-ol in which the hydrogens at positions 5 and 6 are replaced by 4-[2-(pyrrolidin-1-yl)ethoxy]phenyl and phenyl groups, respectively (the 5R,6S-stereoisomer). It is a selective estrogen receptor modulator indicated for the prevention and treatment of osteoporosis in post-menopausal women. It has a role as an antineoplastic agent, a cardioprotective agent, an estrogen receptor agonist, an estrogen receptor antagonist and a bone density conservation agent. It is a member of tetralins, an aromatic ether, a member of naphthols and a N-alkylpyrrolidine.
Clinical Use
Lasofoxifene is a very potent second-generation SERM currently in phase III clinical trials for the treatment and prevention of osteoporosis in postmenopausal women.
Lasofoxifene Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9702 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| Shanghai Innopharm Industrial Co., Ltd. | +86-21-59960785 +86-17701845089 | sales@hoyaopharm.com | China | 261 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |