Mazdutide | 2259884-03-0

Mazdutide Properties

form	Solid
color	White to off-white
FDA UNII	MB76Z4IBZ5

Mazdutide Chemical Properties,Uses,Production

clinical trial

Mazdutide (IBI362 or LY3305677) is a synthetic peptide analogue of mammalian oxyntomodulin and a once-weekly GLP-1 and glucagon receptor dual agonist. In a 12-week multiple-ascending-dose phase 1b study in Chinese patients with type 2 diabetes (clinical trial reg. no. NCT04466904, clinicaltrials.gov), mean changes in HbA1c ranged from −1.46% to −2.23% with mazdutide (−1.98% with 1.5 mg dulaglutide and −0.87% with placebo). Mean changes in body weight were up to −5.4% with mazdutide, −0.9% with dulaglutide, and −1.1% with placebo. A 12- to 16-week phase 1b study in Western patients with type 2 diabetes (clinical trial reg. no. NCT03928379, clinicaltrials.gov) reported mean changes in HbA1c up to −2.16% with mazdutide (−0.70% with placebo) and mean changes in body weight up to −11.2 kg with mazdutide (−2.0 kg with placebo). In both studies, mazdutide was well tolerated, with gastrointestinal adverse events most frequently reported.

Description

Mazdutide (also known as IBI362 or LY3305677), a novel once-weekly glucagon-like peptide-1 (GLP-1) and glucagon receptor dual agonist, achieved 12-week body weight loss of up to 6.4% at doses up to 6 mg in Chinese adults with overweight or obesity. It is the first GLP-1R/GCGR dual agonist to succeed in Phase 3 trials. As mazdutide's first registrational trial for weight management, the results of GLORY-1 not only further confirm the efficacy and safety of the mazdutide in a large population but also provide high-quality clinical evidence of long-term pharmacotherapy weight management specifically for the Chinese population with overweight or obesity[1].

Biological Functions

As a mammalian oxyntomodulin (OXM) analog, in addition to the effects of GLP-1 receptor agonists on promoting insulin secretion, lowering blood glucose, and reducing body weight, mazdutide may also increase energy expenditure and improve hepatic fat metabolism through the activation of glucagon receptor. Mazdutide has demonstrated robust weight loss and glucose-lowering effects in clinical studies, as well as multiple cardio-metabolic benefits, including reducing waist circumference, blood lipids, blood pressure, blood uric acid, liver enzymes, liver fat content and improving insulin sensitivity.

Side effects

Compared to placebo, it was also associated with reductions in fasting plasma glucose and HbA1c among patients with diabetes. Mazdutide was associated with more side effects, primarily gastrointestinal-related disorders, such as decreased appetite, nausea, vomiting and diarrhea. Moreover, all participants on Mazdutide experienced an increase in heart rates. However, these side effects were transient and mild to moderate in severity, and no participant discontinued treatment due to the side effects[2].

References

[1] Nalisa, David Lubasi et al. “Efficacy and safety of Mazdutide on weight loss among diabetic and non-diabetic patients: a systematic review and meta-analysis of randomized controlled trials.” Frontiers in Endocrinology 13 1 (2024).

References

[1] Linong Ji. “Safety and efficacy of a GLP-1 and glucagon receptor dual agonist mazdutide (IBI362) 9 mg and 10 mg in Chinese adults with overweight or obesity: A randomised, placebo-controlled, multiple-ascending-dose phase 1b trial.” EClinicalMedicine (2022): 101691.

Mazdutide Preparation Products And Raw materials

Raw materials

Preparation Products

Mazdutide Suppliers

Global( 48)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Strong peptide cross-border e-commerce Co. LTD	+undefined13930052870	qt01@qiangtaipharm.com	China	84	58
Cellmano Biotech Limited	0551-65326643 18156095617	info@cellmano.com	China	995	58
Shanghai Longyu Biotechnology Co., Ltd.	+8619521488211	info@longyupharma.com	China	2558	58
Changsha MOL Changes Biotechnology Co., Ltd.	+8619375158599	info@molchanges.com	China	5223	58
Hebei Jiafan Trading Company Limited	+8615354498258	sales01@jiafan88.com	China	111	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-81148696 +86-15536356810	1022@dideu.com	China	3882	58
Wuhan senwayer century chemical Co.,Ltd	+undefined-27-86652399 +undefined13627115097	market02@senwayer.com	China	917	58
Shaanxi Franta Biotechnology Co., Ltd	+86-13082019107 +86-13082019107	admin@flanderff.com	China	244	58
Hebei Kangcang new material Technology Co., LTD	+8615713292910	Nancy@kangcang.com.cn	China	341	58

Supplier	Advantage
BOC Sciences	58
Strong peptide cross-border e-commerce Co. LTD	58
Cellmano Biotech Limited	58
Shanghai Longyu Biotechnology Co., Ltd.	58
Changsha MOL Changes Biotechnology Co., Ltd.	58
Hebei Jiafan Trading Company Limited	58
Shaanxi Dideu Medichem Co. Ltd	58
Wuhan senwayer century chemical Co.,Ltd	58
Shaanxi Franta Biotechnology Co., Ltd	58
Hebei Kangcang new material Technology Co., LTD	58

View Lastest Price from Mazdutide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-02-12	Mazdutide 2259884-03-0	US $0.00-0.00 / BOX	1BOX	99.99%	1000	Shandong Huizhihan Supply Chain Co., Ltd
2025-02-11	Mazdutide 2259884-03-0	US $5.00 / Box	1Box	99.99%	20000 boxes	Hebei Jiafan Trading Company Limited
2024-12-25	Mazdutide 2259884-03-0	US $40.00-35.00 / box	1box	99.9+	2000box	Strong peptide cross-border e-commerce Co. LTD

Mazdutide
2259884-03-0
US $0.00-0.00 / BOX
99.99%
Shandong Huizhihan Supply Chain Co., Ltd

Mazdutide
2259884-03-0
US $5.00 / Box
99.99%
Hebei Jiafan Trading Company Limited

Mazdutide
2259884-03-0
US $40.00-35.00 / box
99.9+
Strong peptide cross-border e-commerce Co. LTD

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