DPQ
- CAS No.
- 129075-73-6
- Chemical Name:
- DPQ
- Synonyms
- DPQ;DMEM(Low Glucose);PARP Inhibitor III, DPQ;PARP Inhibitor III, DPQ - CAS 129075-73-6 - Calbiochem;3,4-DIHYDRO-5[4-(1-PIPERINDINYL)BUTOXY]-1(2H)-ISOQUINOLINE;3,4-DIHYDRO-5[4-(1-PIPERIDINYL)BUTOXYL]-1(2H)-ISOQUINOLINE;5-(4-piperidin-1-ylbutoxy)-3,4-dihydro-2H-isoquinolin-1-one;3,4-DIHYDRO-5-[4-(1-PIPERIDINYL)BUTOXY]-1(2H)-ISOQUINOLINONE;3,4-DIHYDRO-5-[4-(1-PIPERIDINYL)BUTOXYL]-1(2H)-ISOQUINOLINONE;1(2H)-Isoquinolinone, 3,4-dihydro-5-[4-(1-piperidinyl)butoxy]-
- CBNumber:
- CB5126204
- Molecular Formula:
- C18H26N2O2
- Molecular Weight:
- 302.41
- MDL Number:
- MFCD02258932
- MOL File:
- 129075-73-6.mol
- MSDS File:
- SDS
| Melting point | 107-109° |
|---|---|
| Boiling point | 528.8±50.0 °C(Predicted) |
| Density | 1.096±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: Soluble |
| form | solid |
| pka | 14.54±0.20(Predicted) |
| color | White to off-white |
| FDA UNII | 5007H57E2L |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H335-H319-H315 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
DPQ price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D5314 | DPQ ≥98% (HPLC), solid | 129075-73-6 | 1mg | $130 | 2024-03-01 | Buy |
| Sigma-Aldrich | 300270 | PARP Inhibitor III, DPQ | 129075-73-6 | 1mg | $130 | 2024-03-01 | Buy |
| Cayman Chemical | 14450 | DPQ ≥99% | 129075-73-6 | 1mg | $56 | 2024-03-01 | Buy |
| Cayman Chemical | 14450 | DPQ ≥99% | 129075-73-6 | 5mg | $201 | 2024-03-01 | Buy |
| Sigma-Aldrich | D5314 | DPQ ≥98% (HPLC), solid | 129075-73-6 | 5mg | $443 | 2024-03-01 | Buy |
DPQ Chemical Properties,Uses,Production
Description
The poly(ADP-
Uses
DPQ has been used as a PARP1 (poly(ADP-ribose) polymerase 1) inhibitor in in vivo studies to determine the loss of γ-H2AX (H2A histone family member X) upon irradiation.
Uses
Reagent for inhibition of PARP.
Uses
3,4-Dihydro-5-[4-(1-piperidinyl)butoxy]-1(2H)-isoquinolinone is a potent inhibitor of poly(ADP-ribose) polymerases, a family of enzymes that plays a crucial role in DNA repair and apoptosis in respons e to reactive oxygen and nitrogen species.
Biochem/physiol Actions
3,4-Dihydro-5-[4-(1-piperidinyl)butoxyl]-1(2H)-isoquinolinone (DPQ) is known to decrease the PARP 1 (poly(ADP-ribose) polymerase 1) mediated apoptosis under the influence of ischemia. It is considered as more effective inhibitor than the traditionally used PARP1 inhibitor 3-aminobenzamide.
storage
+4°C
DPQ Preparation Products And Raw materials
Raw materials
Preparation Products
DPQ Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chengdu HuaXia Chemical Reagent Co. Ltd | 400-1166-196 13458535857 | cdhxsj@163.com | China | 13358 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Shandong Xiya Chemical Co., Ltd. | 4009903999 13395398332 | sales@xiyashiji.com | China | 20810 | 60 |
| Shandong Ono Chemical Co., Ltd. | 0539-6362799 20） | China | 9998 | 58 | |
| Chengdu Saint - Kay Biotechnology Co., Ltd. | 028-85157043 15882256948 | 676046971@qq.com | China | 4392 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55717 | 58 |