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Aminoglutethimide

Aminoglutethimide
Aminoglutethimide structure
CAS No.
125-84-8
Chemical Name:
Aminoglutethimide
Synonyms
Elipten;Cytadren;Ba-16038;ORIMETEN;NSC-330915;AKOS NCG1-0032;AMINOGLUTETHAMIDE;AMINOGLUTETHIMIDE;TIMTEC-BB SBB000711;DL-AMINOGLUTETHIMIDE
CBNumber:
CB5131691
Molecular Formula:
C13H16N2O2
Formula Weight:
232.28
MOL File:
125-84-8.mol

Aminoglutethimide Properties

Melting point:
152-154 °C(lit.)
Boiling point:
374.44°C (rough estimate)
Density 
1.1099 (rough estimate)
refractive index 
1.6450 (estimate)
storage temp. 
2-8°C
solubility 
H2O: 0.2 mg/mL, slightly soluble
form 
neat
color 
white
Water Solubility 
Soluble in water (2 mg/ml at 20°C), methanol (50 mg/ml), ethanol (7 mg/ml at 25°C), DMSO (20 mg/ml at 25°C), and chloroform.
Merck 
14,440
CAS DataBase Reference
125-84-8(CAS DataBase Reference)
NIST Chemistry Reference
Aminoglutethimide(125-84-8)
EPA Substance Registry System
2,6-Piperidinedione, 3-(4-aminophenyl)-3-ethyl- (125-84-8)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
RIDADR  3249
WGK Germany  3
RTECS  MA4026950
HazardClass  6.1(b)
PackingGroup  III
Hazardous Substances Data 125-84-8(Hazardous Substances Data)
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Aminoglutethimide price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1025205 Aminoglutethimide United States Pharmacopeia (USP) Reference Standard 125-84-8 200mg $352.8 2018-11-20 Buy
Sigma-Aldrich A9657 DL-Aminoglutethimide 125-84-8 1g $845 2018-11-20 Buy
Alfa Aesar J62182 DL-Aminoglutethimide, 99% 125-84-8 1g $29.7 2018-11-13 Buy
Alfa Aesar J62182 DL-Aminoglutethimide, 99% 125-84-8 5g $79.3 2018-11-13 Buy
Cayman Chemical 20947 Aminoglutethimide ≥98% 125-84-8 5g $69 2018-11-19 Buy

Aminoglutethimide Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

aromatase inhibitor, antineoplastic, testosterone suppressant

Uses

An aromatase inhibitor. Also blocks adrenal steroidogenesis

Definition

ChEBI: A dicarboximide that is a six-membered cyclic compound having ethyl and 4-aminophenyl substituents at the 3-position.

brand name

Cytadren (Novartis);C-16038-ba;Crytraden;Doredin;Mamomit;Ormeten.

World Health Organization (WHO)

Aminoglutethimide, a weak anticonvulsant, was introduced in 1960 for use in the treatment of epilepsy. However, its adrenocortical suppressant activity gave rise to serious adverse effects. The FDA decision in 1966 was taken in respect of a preparation indicated in epilepsy. In 1980 preparations containing aminoglutethimide were reintroduced in the USA exclusively for the treatment of Cushing's disease. In 1986 they were also registered in Saudi Arabia for use in Cushing's syndrome and for the treatment of breast cancer. In some other countries these preparations are additionally approved for carcinoma of the prostate.

General Description

Aminoglutethimide, 3-(4-aminophenyl)-3-ethyl-2,6-piperidinedione, is mainly usedto treat Cushing syndrome, a condition of adrenal steroidexcess, a use in which the P450scc inhibition of thiscompound is exploited rather than its aromatase inhibition.Aminoglutethimide is a weak inhibitor of aromataseand has been used successfully in the treatment of estrogen-dependent breast cancer. Because of the developmentof more selective aromatase inhibitors, the use ofaminoglutethimide for its ability to inhibit aromatase is notsupported.

Metabolic pathway

Following administration of a single oral dose of 14C- aminoglutethimide to rats, guinea pigs, rabbits, and man, more than 89% of the dose is excreted in urine and feces within 72h, and dogs eliminate only 51% in this time. Extensive metabolism occurs in all species, with N-acetylaminoglutethimide being the major metabolite except for dogs and man. In the latter two species, the unchanged drug is the main product excreted. As shown in the pathways, it appears that aminoglutethimide is metabolized by several pathways in man and, of the ten metabolites, only two are present in any quantity, namely N-acetylaminoglutethimide and N-hydroxyaminoglutethimide, the latter increasing during the course of treatment.

Aminoglutethimide Preparation Products And Raw materials

Raw materials

Preparation Products


Aminoglutethimide Suppliers

Global( 93)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3203 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21968 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 19923 58
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bxy@titansci.com China 13922 59
Chemfun Medical Technology(Shanghai) Co., Ltd. 021-67220633 & 021-37212706
+86-21-67220638 chemfun@chemfun.net China 21815 59
LGM Pharma 1-(800)-881-8210
615-250-9817 inquiries@lgmpharma.com United States 1943 70
Shanghai Longsheng chemical Co.,Ltd. 021-58099637,58099652,58099650,58099609 To 8009,8068; 13585536065,QQ:975986869
0086-21-33191781 sales@shlschem.com; bin.wu@shlschem.com;xianjun.hong@shlschem.com China 9824 59
Chemsky(shanghai)International Co.,Ltd. 021-50135380
shchemsky@sina.com China 32365 50

View Lastest Price from Aminoglutethimide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-15 Aminoglutethimide
125-84-8
US $1.00 / kg 1kg 99% Customized career henan chemical co

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