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Nisoldipine

Nisoldipine
Nisoldipine structure
CAS No.
63675-72-9
Chemical Name:
Nisoldipine
Synonyms
Sular;SYSCOR;Syseor;NORVASC;Nisocor;Nikameal;ZADIPINA;BAYMYCARD;Nisomynard;BAY K 5552
CBNumber:
CB5147166
Molecular Formula:
C20H24N2O6
Formula Weight:
388.41
MOL File:
63675-72-9.mol

Nisoldipine Properties

Melting point:
147-148°C
Boiling point:
503.3±50.0 °C(Predicted)
Density 
1.205±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
DMSO: >10mg/mL
form 
powder
pka
2.67±0.70(Predicted)
color 
yellow
Merck 
14,6565
InChIKey
VKQFCGNPDRICFG-UHFFFAOYSA-N
CAS DataBase Reference
63675-72-9(CAS DataBase Reference)
NIST Chemistry Reference
Nisoldipine(63675-72-9)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H312
Precautionary statements  P280
Hazard Codes  Xn
Risk Statements  20/21/22
Safety Statements  36
WGK Germany  3
RTECS  US7975600
HS Code  2933399090

Nisoldipine price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich N0165 Nisoldipine ≥98% (HPLC) 63675-72-9 10mg $65.4 2018-11-13 Buy
Sigma-Aldrich N0165 Nisoldipine ≥98% (HPLC) 63675-72-9 50mg $272 2018-11-13 Buy
TCI Chemical N0900 Nisoldipine >98.0%(HPLC)(N) 63675-72-9 1g $142 2018-11-22 Buy
TCI Chemical N0900 Nisoldipine >98.0%(HPLC)(N) 63675-72-9 5g $495 2018-11-22 Buy
Alfa Aesar H37972 Nisoldipine 98% 63675-72-9 5g $360 2018-11-20 Buy

Nisoldipine Chemical Properties,Uses,Production

Description

Nisoldipine D4  is another long-acting dihydropyridine calcium channel blocker effective in the treatment of hypertension and angina pectoris. It is reported to have little or no cardiodepressive activity and to be more effective than nifedipine in reducing blood pressure in hypertensives. Nisoldipine has also been shown to be effective in the management of congestive heart failure. Reduction in dosage is necessary in patients with hepatic, but not renal impairment.

Chemical Properties

Nisoldipine D4 is Light Tan Crystals

Originator

Bayer AG (Germany)

Uses

Dihydropyridine calcium channel blocker. Antihypertensive and antianginal

Uses

urease inhibitor

Uses

Labeled Nisoldipine, intended for use as an internal standard for the quantification of Nisoldipine by GC- or LC-mass spectrometry.

Definition

ChEBI: A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a methoxycarbonyl group at position 3, an o-nitrophenyl group at position 4, and an isobutoxycarbonyl group at position 5. The racemate, calcium channel blocker, is used in the treatment of hypertension and angina pectoris.

brand name

Sular (Sciele);Baymycard.

General Description

In vitro studies show that the effects ofnisoldipine, 1,4-dihydro-2, 6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinecarboxylic acid methyl 2-methylpropyl ester(Sular), on contractile processes are selective, with greaterpotency on vascular smooth muscle than on cardiac muscle.
Nisoldipine is highly metabolized, with five majormetabolites identified. As with most of the dihydropyridines,the cytochrome P450 (CYP) 3A4 isozyme is mainlyresponsible for the metabolism of nisoldipine. The majorbiotransformation pathway appears to involve the hydroxylationof the isobutyl ester side chain. This particular metabolitehas approximately 10% of the activity of the parentcompound.

Nisoldipine Preparation Products And Raw materials

Raw materials

Preparation Products


Nisoldipine Suppliers

Global( 229)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3194 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21671 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sale@mainchem.com CHINA 32447 55
Hebei Chisure Biotechnology Co., Ltd.
+8613292890173
0311 66567340 luna@speedgainpharma.com CHINA 1016 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30002 58
Jinan Jianfeng Chemical Co., Ltd
15562555968
info@pharmachemm.com CHINA 295 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23980 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28236 58

View Lastest Price from Nisoldipine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-07-26 Nisoldipine
63675-72-9
US $100.00 / KG 1KG 98% 100KG career henan chemical co
2019-04-11 Nisoldipine
63675-72-9
US $1.00 / kg 1kg 99% 500KG Hebei Jimi Trading Co., Ltd.
2018-07-20 Nisoldipine
63675-72-9
US $10.00 / KG 10G 99% 500kg/month Hebei Chisure Biotechnology Co., Ltd.

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