CETRORELIX
- CAS No.
- 145672-81-7
- Chemical Name:
- CETRORELIX
- Synonyms
- Cetrorelix impurity;Ns 75a;D 20761;Ovurelix;Cetrotid;Sb 075 acetate;SB-075 ACETATE;NS-75A;Cetrorelix( x acetate);Cetrorelix acetate (SB-75);Cetrorelix Acetate,SB-075 acetate,NS-75A, >98%
- CBNumber:
- CB51478311
- Molecular Formula:
- C70H92ClN17O14.C2H4O2
- Molecular Weight:
- 1491.11
- MDL Number:
- MFCD08459466
- MOL File:
- 145672-81-7.mol
| storage temp. | -20°C |
|---|---|
| solubility | methanol: soluble10% |
| form | solid |
| Water Solubility | Soluble in water |
| NCI Dictionary of Cancer Terms | D-20761 |
| FDA UNII | XPQ226310Q |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H360F |
| Precautionary statements | P201-P280-P308+P313 |
| Risk Statements | 60-63 |
| Safety Statements | 22 |
| WGK Germany | 3 |
CETRORELIX price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C5249 | Cetrorelix acetate ≥98% (HPLC) | 145672-81-7 | 5mg | $129 | 2024-03-01 | Buy |
| Sigma-Aldrich | C5249 | Cetrorelix acetate ≥98% (HPLC) | 145672-81-7 | 25mg | $516 | 2024-03-01 | Buy |
| Cayman Chemical | 23910 | Cetrorelix (acetate) ≥95% | 145672-81-7 | 1mg | $40 | 2024-03-01 | Buy |
| Cayman Chemical | 23910 | Cetrorelix (acetate) ≥95% | 145672-81-7 | 5mg | $99 | 2024-03-01 | Buy |
| Cayman Chemical | 23910 | Cetrorelix (acetate) ≥95% | 145672-81-7 | 10mg | $158 | 2024-03-01 | Buy |
CETRORELIX Chemical Properties,Uses,Production
Description
Cetrorelix is a synthetic peptide antagonist of the gonadotropin-releasing hormone receptor (GnRHR) with a Kd value of 0.2 nM for radioligand binding to murine LTK- cells expressing human GnRHR. It inhibits the activation of hGnRHR and a downstream luciferase reporter gene in murine LTK- cells by the GnRHR agonist [D-Trp6]GnRH (IC50 = 1.2 nM). In vivo, cetrorelix (60 μg per day) reduces tumor volume to 35% of control and decreases serum luteinizing hormone levels by 50% in a human epithelial ovarian cancer mouse xenograft model. Centrorelix (0.5 mg/kg) protects the primordial follicles (PMF) in mouse ovaries from damage induced by cyclophosphamide with 65% to 86% PMF survival compared to 46% PMF survival with a saline control. Formulations containing cetrorelix have been used to prevent ovulation during in vitro fertilization.
Uses
Cetrorelix, a luteinizing hormone releasing hormone receptor (LHRHR) antagonist, was used to study its safety, mechanism of action, metabolism, and efficacy as a therapeutic agent for the treatment of blood cancers such as multiple myeloma (MM). Cetrorelix is used to evaluate its effects on a wide range of physiological processes and malignancies that involve luteinizing hormone releasing hormone receptor signaling pathways involving processes such as steroidogenesis.
Uses
Cetrorelix Acetate is an gonadotropin-releasing hormone antagonist and is used to treat hormone-sensitive cancers of the prostate and breast.
Definition
ChEBI: The acetic acid salt of cetrorelix. A gonadotrophin-releasing hormone (GnRH) antagonist, it is used for treatment of infertility and of hormone-sensitive cancers of the prostate and breast.
Biochem/physiol Actions
Cetrorelix acetate is a luteinizing hormone releasing hormone receptor antagonist. It causes prepubertal reduction in bone modeling, bone density and bone strength comparable to post-menopausal bone loss.
storage
Store at -20°C
CETRORELIX Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Cellmano Biotech Limited | 0551-65326643 18156095617 | info@cellmano.com | China | 999 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10297 | 58 |
| Longyan Tianhua Biological Technology Co., Ltd | 0086 18039857276 18039857276 | CHINA | 2783 | 58 | |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Chengdu Youngshe Chemical Co., Ltd. | +8618108235634 | Cecilia@youngshechem.com | China | 2345 | 58 |
View Lastest Price from CETRORELIX manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-11-16 | CETRORELIX
145672-81-7
|
US $15.00 / g | 1Kg/Bag | 99% | 20 Tons | Longyan Tianhua Biological Technology Co., Ltd | |
 |
2019-07-06 | CETRORELIX
145672-81-7
|
US $7.00 / KG | 1KG | 99% | 100kG | Career Henan Chemical Co |
-
- CETRORELIX
145672-81-7
- US $15.00 / g
- 99%
- Longyan Tianhua Biological Technology Co., Ltd
-
- CETRORELIX
145672-81-7
- US $7.00 / KG
- 99%
- Career Henan Chemical Co