(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride
- CAS No.
- 119770-60-4
- Chemical Name:
- (1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride
- Synonyms
- Des Loratadine methanone;Loratadine Methyl Ketone;Loratadine Impurity 10 HCl;Loratadine Impurity 36 HCl;Loratadine Impurity 39 HCl;Loratadine Methanone Impurity;(3-(3-chlorophenethyl)pyridin-;Desloratadine Methanone Impurity;Desloratadine?Methanone?Impurity?HCl;(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridiny...
- CBNumber:
- CB51503925
- Molecular Formula:
- C20H24Cl2N2O
- Molecular Weight:
- 379.32
- MDL Number:
- MFCD08063842
- MOL File:
- 119770-60-4.mol
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07,GHS05,GHS09 |
---|---|
Signal word | Warning |
Hazard statements | H400-H318-H410-H302 |
Precautionary statements | P264-P270-P301+P312-P330-P501-P273-P391-P501-P273-P391-P501-P280-P305+P351+P338-P310 |
(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Medical Isotopes, Inc. | 82364 | (1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone | 119770-60-4 | 1mg | $490 | 2021-12-16 | Buy |
Chemenu | CM175915 | (3-(3-chlorophenethyl)pyridin-2-yl)(1-methylpiperidin-4-yl)methanonehydrochloride 95% | 119770-60-4 | 1g | $916 | 2021-12-16 | Buy |
Crysdot | CD11333995 | (3-(3-Chlorophenethyl)pyridin-2-yl)(1-methylpiperidin-4-yl)methanonehydrochloride 95+% | 119770-60-4 | 1g | $972 | 2021-12-16 | Buy |
(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride Chemical Properties,Uses,Production
Uses
(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride is an important fine chemical, Desloratadine methanone impurity, which can be used in organic synthetic materials or chemical research.
Synthesis
(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride is prepared by the reaction of 4-chloro-1-methylpiperidine and 3-(3-chlorophenethyl)picolinonitrile. The specific synthesis steps are as follows:
Add magnesium (3.6g) and a small amount of iodine into the reaction flask under nitrogen protection,Add re-distilled THF (20ml), 1,2-dibromoethane (1ml), 4-chloro-N-methylpiperidine (1ml), and stir at 75°C; after the liquid surface of the system is foamed, add 4- Chloro-N-methylpiperidine (20.4ml) was dissolved in THF (240ml) and slowly added dropwise. After the dropwise addition, it was reacted for 1h and cooled to room temperature for later use. Compound V (26.0g, 107mmol) was dissolved in THF (250ml) under nitrogen protection;Add the prepared Grignard reagent dropwise to the reaction flask at room temperature to control the temperature of the system; after the dropwise addition, control the temperature of the system at 40-50°C and continue the reaction for 1 hour. After the reaction is completed, adjust the pH of the reaction solution to below 2 with a 2mol/L HCl solution, and continue the reaction at room temperature for 1 hour; after the reaction is completed, THF is distilled off under reduced pressure, and then the pH value of the solution is adjusted with a 50% NaOH solution. Adjust to 3-4, crystallize in an ice-water bath, filter and wash, and dry the solid to obtain a pale yellow powder ((1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride, 33.8 g, 83.3%).
(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9802 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29831 | 58 |
sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12382 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
View Lastest Price from (1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2022-10-11 | (1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride
119770-60-4
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
2021-10-14 | (1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride
119770-60-4
|
US $1.10 / g | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited |
- (1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride
119770-60-4
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
- (1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride
119770-60-4
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited