ChemicalBook >> CAS DataBase List >>(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride

(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride

CAS No.
119770-60-4
Chemical Name:
(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride
Synonyms
Des Loratadine methanone;Loratadine Methyl Ketone;Loratadine Impurity 10 HCl;Loratadine Impurity 36 HCl;Loratadine Impurity 39 HCl;Loratadine Methanone Impurity;(3-(3-chlorophenethyl)pyridin-;Desloratadine Methanone Impurity;Desloratadine?Methanone?Impurity?HCl;(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridiny...
CBNumber:
CB51503925
Molecular Formula:
C20H24Cl2N2O
Molecular Weight:
379.32
MDL Number:
MFCD08063842
MOL File:
119770-60-4.mol
Last updated:2024-01-08 17:20:55

(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride Properties

Melting point 183-185 °C

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS07,GHS05,GHS09
Signal word  Warning
Hazard statements  H400-H318-H410-H302
Precautionary statements  P264-P270-P301+P312-P330-P501-P273-P391-P501-P273-P391-P501-P280-P305+P351+P338-P310

(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Medical Isotopes, Inc. 82364 (1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone 119770-60-4 1mg $490 2021-12-16 Buy
Chemenu CM175915 (3-(3-chlorophenethyl)pyridin-2-yl)(1-methylpiperidin-4-yl)methanonehydrochloride 95% 119770-60-4 1g $916 2021-12-16 Buy
Crysdot CD11333995 (3-(3-Chlorophenethyl)pyridin-2-yl)(1-methylpiperidin-4-yl)methanonehydrochloride 95+% 119770-60-4 1g $972 2021-12-16 Buy
Product number Packaging Price Buy
82364 1mg $490 Buy
CM175915 1g $916 Buy
CD11333995 1g $972 Buy

(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride Chemical Properties,Uses,Production

Uses

(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride is an important fine chemical, Desloratadine methanone impurity, which can be used in organic synthetic materials or chemical research.

Synthesis

(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride is prepared by the reaction of 4-chloro-1-methylpiperidine and 3-(3-chlorophenethyl)picolinonitrile. The specific synthesis steps are as follows:
Add magnesium (3.6g) and a small amount of iodine into the reaction flask under nitrogen protection,Add re-distilled THF (20ml), 1,2-dibromoethane (1ml), 4-chloro-N-methylpiperidine (1ml), and stir at 75°C; after the liquid surface of the system is foamed, add 4- Chloro-N-methylpiperidine (20.4ml) was dissolved in THF (240ml) and slowly added dropwise. After the dropwise addition, it was reacted for 1h and cooled to room temperature for later use. Compound V (26.0g, 107mmol) was dissolved in THF (250ml) under nitrogen protection;Add the prepared Grignard reagent dropwise to the reaction flask at room temperature to control the temperature of the system; after the dropwise addition, control the temperature of the system at 40-50°C and continue the reaction for 1 hour. After the reaction is completed, adjust the pH of the reaction solution to below 2 with a 2mol/L HCl solution, and continue the reaction at room temperature for 1 hour; after the reaction is completed, THF is distilled off under reduced pressure, and then the pH value of the solution is adjusted with a 50% NaOH solution. Adjust to 3-4, crystallize in an ice-water bath, filter and wash, and dry the solid to obtain a pale yellow powder ((1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride, 33.8 g, 83.3%).
(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride synthesis

(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 67)Suppliers
Supplier Tel Email Country ProdList Advantage
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28180 58
Standardpharm Co. Ltd.
86-714-3992388 overseasales1@yongstandards.com United States 14336 58
Alchem Pharmtech,Inc.
8485655694 sales@alchempharmtech.com United States 63711 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 47465 58
ANHUI WITOP BIOTECH CO., LTD
+8615255079626 eric@witopchemical.com China 23556 58
Shaanxi Dideu Medichem Co. Ltd
+86-029-89586680 +86-18192503167 1026@dideu.com China 9802 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250 1026@dideu.com China 29831 58
sgtlifesciences pvt ltd
+8617013299288 dj@sgtlifesciences.com China 12382 58
Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418684 +8618949823763 sales@tnjchem.com China 25363 58
LEAPCHEM CO., LTD.
+86-852-30606658 market18@leapchem.com China 43348 58

View Lastest Price from (1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride pictures 2022-10-11 (1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride
119770-60-4
US $0.00-0.00 / kg 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride pictures 2021-10-14 (1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride
119770-60-4
US $1.10 / g 1g 99.00% 100 Tons Min Dideu Industries Group Limited
(1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride [3-[2-(3-Chlorophenyl)ethyl]-2-pyridinyl](1-methyl-4-piperidinyl)methanone hydrochloride (3-(3-Chlorophenethyl)pyridin-2-yl)(1-methyl-piperidin-4-yl)methanone hydrochloride Loratadine Methanone Impurity [3-[2-(3-chlorophenyl)ethyl]pyridin-2-yl]-(1-methylpiperidin-4-yl)methanone:hydrochloride Loratadine Impurity 10 HCl Desloratadine Methanone Impurity (3-(3-chlorophenethyl)pyridin- Loratadine Impurity ((1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone) {3-[2-(3-Chlorophenyl)ethyl]pyridine-2-yl}-(1-methyl?piperidine-4-yl) (Methonal HCL) Des Loratadine methanone Desloratadine Impurity 3/Desloratadine Methanone Impurity HCl/Desloratadine Ketone Impurity HCl Loratadine Methyl Ketone (1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridinyl]methanone hydrochloride ISO 9001:2015 REACH Desloratadine Methanone Impurity/ Desloratadine Ketone Impurity (Loratadine Methanone Impurity) Loratadine Methanone Impurity (Desloratadine Methanone Impurity/ Desloratadine Ketone Impurity) (1-Methyl-4-piperidinyl)[3-[2-(3-chlorophenyl)ethyl]pyridiny... Loratadine Impurity 36 HCl Desloratadine?Methanone?Impurity?HCl (1-methyl-4-piperidinyl) [3- [2- (3-chlorophenyl) ethyl] pyridin-2-yl] ketone hydrochloride Loratadine Impurity 39 HCl {3-[2-(3-chlorophenyl)ethyl]pyridin-2-yl}(4- methylcyclohexyl)methanone 119770-60-4 C20H24Cl2N2O