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Cefpodoxime proxetil

Brand Name(s) in US
Cefpodoxime proxetil
Cefpodoxime proxetil structure
CAS No.
87239-81-4
Chemical Name:
Cefpodoxime proxetil
Synonyms
BANAN;ORELOX;OTREON;VANTIN;R-3763;CS-807;JP,USP;U-76252;U-76253;CEFODOX
CBNumber:
CB5150483
Molecular Formula:
C21H27N5O9S2
Formula Weight:
557.6
MOL File:
87239-81-4.mol

Cefpodoxime proxetil Properties

Melting point:
111-113°C
RTECS 
XI0367370
storage temp. 
-20?C Freezer
solubility 
Soluble in DMSO
form 
neat
Sensitive 
Light Sensitive
InChIKey
LTINZAODLRIQIX-FBXRGJNPSA-N
CAS DataBase Reference
87239-81-4(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi
Risk Statements  36/37/38-42/43
Safety Statements  22-26-36/37/39
WGK Germany  3
HS Code  30042000
Toxicity LD50 in male, female mice, male, female rats (mg/kg): >10000, >10000, >2000, >2000 s.c., 3502, 2535, >4000, >4000 i.p.; >8000, >8000, >4000, >4000 orally (Nakao, 1988)
Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled Sensitisation, respiratory Category 1 Danger P261, P285, P304+P341, P342+P311,P501
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P284 Wear respiratory protection.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

Cefpodoxime proxetil price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1098027 Cefpodoxime proxetil 87239-81-4 350mg $352.8 2018-11-20 Buy
Sigma-Aldrich A3987 Cefpodoxime proxetil 87239-81-4 50mg $530 2018-11-20 Buy
Alfa Aesar J66061 Cefpodoxime proxetil, 96% 87239-81-4 1g $236 2018-11-13 Buy
Cayman Chemical 25412 Cefpodoxime-d3 ≥99% deuterated forms (d1-d3) 1mg $226 2018-11-19 Buy
Cayman Chemical 25412 Cefpodoxime-d3 ≥99% deuterated forms (d1-d3) 500μg $125 2018-11-19 Buy

Cefpodoxime proxetil Chemical Properties,Uses,Production

Brand Name(s) in US

Simplicef (veterinary drug)
Vantin (human drug)

Description

Cefpodoxime proxetil is an orally active, broad-spectrum cephalosporin especially useful in the treatment of bacterial infections in children. It is a prodrug converted by esterases in the GI walls to cefpodoxime, which reportedly has a bacteriostatic spectrum comparable to injectable third-generation cephem antibiotics.

Chemical Properties

Pale Yellow Solid

Originator

Sankyo (Japan)

Uses

A metabolite of Cefpodoxime Proxetil. An antibacterial.

Uses

An antibacterial. A broad spectrum, orally absorbed third generation cephalosporin, ester prodrug of the active free acid metabolite, Cefpodoxime

Definition

ChEBI: The 1-[(isopropoxycarbonyl)oxy]ethyl (proxetil) ester prodrug of cefpodoxime. After swallowing, hydrolysis of the ester group occurs in the intestinal epithelium, to release active cefpodoxime in the bloodstream. It is used to treat acute otitis media, pha yngitis, and sinusitis.

brand name

Vantin (Pharmacia & Upjohn);Banan.

Clinical Use

Cefpodoxime proxetil (Vantin) is the isopropyloxycarbonylethylester of the third-generation cephalosporincefpodoxime. This orally active prodrug derivative is hydrolyzedby esterases in the intestinal wall and in theplasma to provide cefpodoxime. Tablets and a powder forthe preparation of an aqueous suspension for oral pediatricadministration are available. The oral bioavailability of cefpodoximefrom the proxetil is estimated to be about 50%.Administration of the prodrug with food enhances its absorption.The plasma half-life is 2.2 hours, which permitsadministration on a twice-daily schedule.
Cefpodoxime is a broad-spectrum cephalosporin withuseful activity against a relatively wide range of Grampositiveand Gram-negative bacteria. It is also resistant tomany β-lactamases. Its spectrum of activity includes S.pneumoniae, Streptococcus pyogenes, S. aureus, H. influenzae,M. catarrhalis, and Neisseria spp. Cefpodoxime is alsoactive against members of the Enterobacteriaceae family,including E. coli, K. pneumoniae, and P. mirabilis. It thusfinds use in the treatment of upper and lower respiratory infections,such as pharyngitis, bronchitis, otitis media, andcommunity-acquired pneumonia. It is also useful for thetreatment of uncomplicated gonorrhea.

Cefpodoxime proxetil Preparation Products And Raw materials

Raw materials

Preparation Products


Cefpodoxime proxetil Suppliers

Global( 139)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22043 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32651 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2548 55
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 956 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24118 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 19997 58
GUANGZHOU CHANGTHINKING IMP.&EXP.CO.,LTD 18028682016 13682223272 18922377114 18922377004
020-87659730 dylan@gzbr.com.cn China 199 58
Hubei Dibai Chemical Co., Ltd. 15872383390/15871366807
027-87058617 3497278907@qq.com;1024561249@qq.com China 759 58
Wellman Pharmaceutical Group Limited 15807197853 027-83778875
027-83991220 15807197853@163.com China 2347 58

View Lastest Price from Cefpodoxime proxetil manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-09 Cefpodoxime proxetil
87239-81-4
US $1.00 / KG 1KG 99% 1ton career henan chemical co

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