adoprazine
- CAS No.
- 222551-17-9
- Chemical Name:
- adoprazine
- Synonyms
- SLV313;SLV 313;adoprazine;Unii-7snb18Q89d;Adoprazine (SLV313);SLV 313;SLV313;SLV-313;1-(2,3-Dihydro-1,4-benzodioxin-5-yl)-4-[[5-(4-fluorophenyl)-3-pyridinyl]methyl]piperazine;Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-[[5-(4-fluorophenyl)-3-pyridinyl]methyl]-
- CBNumber:
- CB51518488
- Molecular Formula:
- C24H24FN3O2
- Molecular Weight:
- 405.46
- MDL Number:
- MOL File:
- 222551-17-9.mol
| Boiling point | 565.0±50.0 °C(Predicted) |
|---|---|
| Density | 1.256 |
| storage temp. | Store at -20°C |
| solubility | DMSO : 50 mg/mL (123.32 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble) |
| form | Powder |
| pka | 6.07±0.10(Predicted) |
| FDA UNII | 7SNB18Q89D |
adoprazine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0673 | Adoprazine 98.10% | 222551-17-9 | 5mg | $240 | 2021-12-16 | Buy |
| ChemScene | CS-0673 | Adoprazine 98.10% | 222551-17-9 | 10mg | $408 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0001417 | ADOPRAZINE 95.00% | 222551-17-9 | 5MG | $424.6 | 2021-12-16 | Buy |
| ChemScene | CS-0673 | Adoprazine 98.10% | 222551-17-9 | 50mg | $1080 | 2021-12-16 | Buy |
| DC Chemicals | DC9324 | Adoprazine >98% | 222551-17-9 | 1g | $3600 | 2021-12-16 | Buy |
adoprazine Chemical Properties,Uses,Production
Biological Activity
Adoprazine (SLV313) is a full agonist at the 5-HT1A receptor with a pEC50 of 9 at the h5-HT1A receptor. Adoprazine (SLV313) is a complete antagonist of D2 and D3 receptors with a pA2 value of 9.3 in hD2 receptor and 8.9 in hD3 receptor. It (SLV313) has atypical antipsychotic properties.
in vitro
Adoprazine (SLV313) has high affinity at human recombinant D 2 , D 3 , D 4 , 5-HT < sub> 2B , and 5-HT 1A receptors, with pK i s of 8.4, 8.4, 8.0, 7.9 and 9.1 , respectively. Adoprazine (SLV313) acts as a high potency dopamine D 2 receptor antagonist and an efficacious serotonin 5-HT 1A receptor agonist, with E max value (% effect of 10 μM 5-HT) of 73 and pK B value of 8.5 .
in vivo
Adoprazine (SLV313) (0.1-10 mg/kg; po; single) is sufficient to reduce extracellular 5-HT and increase dopamine levels in the nucleus accumbens in a dose- and time-dependent manner.
| Animal Model: | Male Wistar rats (275-350 g) |
| Dosage: | 0.1 mg/kg, 0.3 mg/kg, 1 mg/kg, 3 mg/kg, 10 mg/kg |
| Administration: | po; single |
| Result : | Led to a dose- and time-dependent increase in extracellular levels of DA, DOPAC, and HVA. In contrast, led to a reduction in 5-HT levels and no change in 5-HIAA levels. |
target
| 5-HT 1A Receptor 9 (pEC 50 ) | D 2 < /sub> Receptor 9.3 (pA2) | D 3 Receptor 8.9 (pA2) | D 4 Receptor 8.0 (pKi) | 5-HT 7 Receptor 7.2 (pKi) | 5-HT 1A < /sub> Receptor 9.1 (pKi) | D 2 Receptor 8.4 (pKi) | D 3 Receptor 8.4 (pKi) |
adoprazine Preparation Products And Raw materials
Raw materials
Preparation Products
adoprazine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 6011 | 61 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |