AG 213
- CAS No.
- 122520-86-9
- Chemical Name:
- AG 213
- Synonyms
- AG 213;RG-50864;TYRPHOSTIN 47;TYRPHOSTIN A47;AG 213 USP/EP/BP;TYRPHOSTIN AG 213;TYRPHOSTIN RG 50864;TYRPHOSTIN A47 99+%;AG 213 (Tyrphostin AG 213);ZGHQGWOETPXKLY-XVNBXDOJSA-N
- CBNumber:
- CB5152917
- Molecular Formula:
- C10H8N2O2S
- Molecular Weight:
- 220.25
- MDL Number:
- MFCD00133902
- MOL File:
- 122520-86-9.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| F | 10 |
AG 213 price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Alfa Aesar | J67345 | Tyrphostin AG-213 97% | 122520-86-9 | 5mg | $104 | 2021-12-16 | Buy |
| Alfa Aesar | J67345 | Tyrphostin AG-213 97% | 122520-86-9 | 10mg | $151 | 2021-12-16 | Buy |
| Cayman Chemical | 10010314 | AG-213 ≥97% | 122520-86-9 | 5mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 10010314 | AG-213 ≥97% | 122520-86-9 | 10mg | $107 | 2024-03-01 | Buy |
| Alfa Aesar | J67345 | Tyrphostin AG-213 97% | 122520-86-9 | 25mg | $356 | 2021-12-16 | Buy |
AG 213 Chemical Properties,Uses,Production
Description
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds that act as PTK blockers. PTK inhibitors which preferentially inhibit the epidermal growth factor (EGF) receptor kinase block EGF-
Uses
Tyrphostin 47 is a potent inhibitor of EGFR kinase activity.
Definition
ChEBI: 3-amino-2-[(3-hydroxy-4-oxo-1-cyclohexa-2,5-dienylidene)methyl]-3-mercapto-2-propenenitrile is a member of quinomethanes.
Biological Activity
Epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR) kinase inhibitor (IC 50 values are 2.4 and 3 μ M respectively). Stimulates microtubule polymerization and promotes neurite outgrowth > 17-fold over basal conditions in vitro . Also weakly inhibits protein kinase C (IC 50 = 60 μ M).
References
[1] romer l h, mclean n, turner c e, et al. tyrosine kinase activity, cytoskeletal organization, and motility in human vascular endothelial cells[j]. molecular biology of the cell, 1994, 5(3): 349-361.
[2] gazit a, yaish p, gilon c, et al. tyrphostins i: synthesis and biological activity of protein tyrosine kinase inhibitors[j]. journal of medicinal chemistry, 1989, 32(10): 2344-2352.
[3] levitzki a, gazit a. tyrosine kinase inhibition: an approach to drug development[j]. science, 1995, 267(5205): 1782.
[4] herbst r s. review of epidermal growth factor receptor biology[j]. international journal of radiation oncology biology physics, 2004, 59(2): s21-s26.
AG 213 Preparation Products And Raw materials
Raw materials
Preparation Products
AG 213 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29321 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44894 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |