Sertraline | 79617-96-2

Sertraline Properties

Boiling point	416.3±45.0 °C(Predicted)
Density	1.25±0.1 g/cm3(Predicted)
pka	pKa 9.48±0.04(H2O I > 0)(Approximate)
Water Solubility	<0.1g/L(room temperature)
InChI	InChI=1S/C17H17Cl2N/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11/h2-6,8,10,12,17,20H,7,9H2,1H3/t12-,17-/m0/s1
InChIKey	VGKDLMBJGBXTGI-SJCJKPOMSA-N
SMILES	[C@@H]1(NC)C2=C(C=CC=C2)[C@H](C2=CC=C(Cl)C(Cl)=C2)CC1
CAS DataBase Reference	79617-96-2(CAS DataBase Reference)
NCI Dictionary of Cancer Terms	sertraline; Zoloft
FDA UNII	QUC7NX6WMB
NCI Drug Dictionary	Zoloft
ATC code	N06AB06
NIST Chemistry Reference	Sertraline(79617-96-2)
EPA Substance Registry System	Sertraline (79617-96-2)

Pharmacokinetic data

Protein binding	>98%
Volume of distribution	25(L/kg)
Biological half-life	26 / Probably unchanged

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS09
Signal word	Warning
Hazard statements	H411-H302
Precautionary statements	P264-P270-P301+P312-P330-P501
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36

Sertraline price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
American Custom Chemicals Corporation	API0004164	SERTRALINE 95.00%	79617-96-2	100MG	$439	2021-12-16	Buy
American Custom Chemicals Corporation	API0004164	SERTRALINE 95.00%	79617-96-2	5G	$524.5	2021-12-16	Buy
Alichem	79617962	(1S,4S)-4-(3,4-Dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine	79617-96-2	250mg	$1284	2021-12-16	Buy
AvaChem	1675B	Sertraline	79617-96-2	100mg	$39	2021-12-16	Buy
AvaChem	1675B	Sertraline	79617-96-2	1g	$69	2021-12-16	Buy

Product number	Packaging	Price	Buy
API0004164	100MG	$439	Buy
API0004164	5G	$524.5	Buy
79617962	250mg	$1284	Buy
1675B	100mg	$39	Buy
1675B	1g	$69	Buy

Sertraline Chemical Properties,Uses,Production

Originator

Lustral,Pfizer,UK

Uses

Antidepressant;5-HT uptake inhibitor

Uses

cis-Sertraline is an isomer of Sertraline. Sertraline is a selective serotonin reuptake inhibitor. It is used as an antidepressant.

Definition

ChEBI: A member of the class of tetralins that is tetralin which is substituted at positions 1 and 4 by a methylamino and a 3,4-dichlorophenyl group, respectively (the S,S diastereoisomer). A selective serotonin-reuptake inhibito (SSRI), it is administered orally as the hydrochloride salt as an antidepressant for the treatment of depression, obsessive-compulsive disorder, panic disorder and post-traumatic stress disorder.

brand name

Zoloft (Pfizer).

Therapeutic Function

Antidepressant

Biological Functions

Sertraline (Zoloft) has an elimination half-life of 25 hours and can be administered once a day, usually in the morning to avoid insomnia. Sertraline undergoes extensive hepatic metabolism, and doses must be reduced in patients with liver disease. Sertraline may produce more gastrointestinal side effects, such as nausea and diarrhea, than does fluoxetine and is generally thought to be less activating than fluoxetine. It is highly bound to serum proteins (98%) and may alter plasma protein binding of other medications.A 14-day washout period is recommended before starting a MAOI. Sertraline is a weak inhibitor of cytochrome P450 2D6. Intensive therapeutic drug monitoring is indicated when combining sertraline with drugs metabolized by this route that have a narrow therapeutic index, such as the TCAs and the type 1C antiarrhythmics propafenone, encainide, and flecainide.

General Description

Inspection of sertraline (Zoloft) (1S,4S) reveals the pharmacophorefor SERT inhibition. The Cl substituents alsopredict tropism for a 5-HT system. The depicted stereochemistryis important for activity.

Mechanism of action

Sertraline is a potent and selective inhibitor of the neuronal reuptake 5-HT transporter. In vitro binding studies suggest that sertraline has a substantially higher selectivity for inhibiting 5-HT reuptake than other SSRIs or TCAs, including clomipramine. It has only weak effects on neuronal uptake of NE and dopamine. Its mechanism of action is common to the SSRIs. Sertraline is very selective, lacking affinity for other neuroreceptors at therapeutic concentrations.

Pharmacokinetics

Sertraline appears to be slowly but well absorbed from the GI tract following oral administration. The oral bioavailability of sertraline in humans ranges from 20 to 36%, suggesting extensive first-pass metabolism to its N-desmethylated metabolite. Food enhances its oral absorption decreasing the time to achieve peak plasma concentrations from approximately 8 to 6 hours. Following multiple dosing, steady-state plasma sertraline concentrations are proportional and linearly related to dose (half-life: single dose, 24 hours; multiple dose, 24 hours). N-desmethylsertraline, sertraline's principal metabolite, exhibits dose-dependent pharmacokinetics. Sertraline and N-desmethylsertraline are distributed into breast milk. Although in elderly patients the elimination half-life is increased to approximately 36 hours, this effect does not appear to be clinically important and does not warrant dosing alterations. Sertraline is primarily metabolized by CYP3A4 N-demethylation in the intestine and liver to its principal metabolite N-desmethylsertraline and several other metabolites. N-desmethylsertraline is approximately 5- to 10 times less potent as an inhibitor of 5-HT reuptake than sertraline. Sertraline and N-desmethylsertraline undergo further metabolism via oxidative deamination and ring hydroxylation and glucuronide conjugation. N-desmethylsertraline has an elimination half-life approximately 2.5 times that of sertraline. Following oral administration, sertraline and its conjugated metabolites are excreted in both urine and feces, and unmetabolized sertraline accounts for less than 5% of oral dose. Plasma clearance of sertraline was approximately 40% lower in geriatric patients. The elimination half-life of sertraline in patients with hepatic disease was prolonged to a mean of 52 hours, compared with 22 hours in individuals without hepatic disease.

Clinical Use

SSRI:
Antidepressant
Post-traumatic stress disorder
Obsessive compulsive disorder

Drug interactions

Sertraline is not a potent inhibitor of CYP3A4, and because CYP2D6 metabolism is a minor pathway for sertraline, drug–drug interactions with these isoforms is unlikely to be of clinical importance. Sertraline is metabolized by more than one CYP isoform in parallel; therefore, drug interactions or genetic polymorphisms are unlikely to cause clinically significant drug interaction via CYP isoform inhibition. Caution is advised, however, when coadministering sertraline with potential object drugs, especially those with narrow therapeutic indices in elderly patients. For example, sertraline has been shown to reduce the clearance of desipramine and imipramine as a result of CYP2D6 inhibition.
Because sertraline is highly protein bound, patients receiving it concurrently with any highly protein-bound drug should be observed for potential adverse effects associated with combined therapy.

Metabolism

Sertraline undergoes extensive first-pass metabolism in the liver. The main pathway is demethylation to inactive N-desmethylsertraline, a process that appears to involve multiple cytochrome P450 isoenzymes; further metabolism and glucuronide conjugation occurs. Sertraline is excreted in about equal amounts in the urine and faeces, mainly as metabolites.

Sertraline Preparation Products And Raw materials

Raw materials

Methylamine Hydrogen Titanium tetrachloride Thionyl chloride Aluminum chloride

Diethyl succinate Hydrogen bromide Potassium tert-butoxide Sodium chloride Mandelic acid

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Preparation Products

Sertraline hydrochloride 1-Naphthalenamine, 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-, (1S,4R)- Sertraline Dimethyl Impurity HCl

Sertraline Suppliers

Global( 166)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Sinoway Industrial co., ltd.	0592-5800732; +8613806035118	xie@china-sinoway.com	China	992	58
Chengdu Aupone Pharmaceutical Co.Ltd.	+86-28-+86-28-87843998-6060-6060 +8618631098571	lijiaqi@aupone.com	China	43	58
Hangzhou ICH Biofarm Co., Ltd	+undefined8613073685410	sales@ichemie.com	China	985	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	sales@sdzschem.com	China	2931	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10297	58

Supplier	Advantage
Sinoway Industrial co., ltd.	58
Chengdu Aupone Pharmaceutical Co.Ltd.	58
Hangzhou ICH Biofarm Co., Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	58
Chongqing Chemdad Co., Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Fuxin Pharmaceutical	58

View Lastest Price from Sertraline manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-10	Sertraline 79617-96-2	US $250.00-180.00 / Kg/Bag	1Kg/Bag	USP, GMP	20tons	Sinoway Industrial co., ltd.
2024-03-18	Sertraline	US $0.00 / gram	10gram	99.99	10Tons	Chengdu Aupone Pharmaceutical Co.Ltd.
2023-11-01	Sertraline 79617-96-2	US $0.00-0.00 / mg	10mg	79617-96-2	100kg	Hangzhou ICH Biofarm Co., Ltd

Sertraline
79617-96-2
US $250.00-180.00 / Kg/Bag
USP, GMP
Sinoway Industrial co., ltd.

Sertraline
US $0.00 / gram
99.99
Chengdu Aupone Pharmaceutical Co.Ltd.

Sertraline
79617-96-2
US $0.00-0.00 / mg
79617-96-2
Hangzhou ICH Biofarm Co., Ltd

79617-96-2(Sertraline)Related Search:

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Kresoxim-methyl Dichloromethylphenylsilane Basic Violet 1 SERTRALINE MANDELATE,SERTRALINE HYDROCHLORIDE,SERTRALINE HCL FORM II,SERTRALINE HCL FORM I Paraquat dichloride

Paroxetine Amitriptyline (1S,4S)-4-(3,4-dichlorophenyl)-N-(trideuteriomethyl)-1,2,3,4-tetrahydronaphthalen-1-amine:hydrochloride

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Sertraline HCL API Sertraline Base 1-NaphthalenaMine,4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-Methyl-, (1S,4S)- (1s-cis)-1,2,3,4-tetrahydro-4-(3,4-dichlorophenyl)-n-methyl-1-naphthalenamin 1,2,3,4-tetrahydro-4-(3,4-dichlorophenyl)-n-methyl-1-naphthalenamin(1s-cis cp51974 (1s,4s)-4-(3,4-dichlorophenyl)-n-methyl-1,2,3,4-tetrahydro-1-naphthalenamine (1s-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-naphthalenamine SERTRALINE 4(3,4-dichlorophenyl)1,2,3,4 tetrahydro-N-methyl-1-naphthalenamine (cis-racemate) (intermediate of sertraline hcl) (1S,4R)-4-(3,4-dichlorophenyl)-N-methyl-tetralin-1-amine Sertraline (base and/or unspecified salts) CIS-(1S)(1R)-N-METHYL-4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-1- NAPHTHALENAMI SERTRALINE HYDROCHLORIDE, 99.0+% 4(3,4-DICHLOROPHENYL)1,2,3,4 TETRAHYDRO-N-METHYL-1-NAPHTHALENAMINE (CIS-RACEMATE) (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenyl]-N-methylamine (1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine (1S,4S)-N-Methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalene-1-amine (1S,4S)-N-Methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalene-1β-amine cis-(+)-Sertraline 1S, 3,4-DehydroSertraline 1S, 4-(SR)-Hydroxy Sertraline Sertraline(Hydrochloride form) Sertraline for system suitability CRS Sertraline USP/EP/BP SertralineQ: What is Sertraline Q: What is the CAS Number of Sertraline Q: What is the storage condition of Sertraline Q: What are the applications of Sertraline Zoloft Sertraline for peak identification CRS Adjuvin Atruline Gladem Sealdin Tatig Tresleen 79617-96-2 C16H15Cl2NHC C17H17Cl2N C17H16Cl2HCl API Amines (intermediate of sertraline hcl) Sertraline 79617-96-2