7-Dehydrocholesterol

7-Dehydrocholesterol Properties

Melting point	148-152 °C(lit.)
alpha	-116 º (C=1, CHCL3)
Boiling point	451.27°C (rough estimate)
Density	0.9717 (rough estimate)
refractive index	1.5100 (estimate)
storage temp.	-20°C
pka	14.91±0.70(Predicted)
optical activity	[α]20/D -115±8°, c = 1% in chloroform
Water Solubility	Insoluble
Merck	13,2887
BRN	2224615
InChIKey	UCTLRSWJYQTBFZ-DDPQNLDTSA-N
CAS DataBase Reference	434-16-2(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	BK1IU07GKF
NIST Chemistry Reference	Cholesta-5,7-dien-3-ol, (3«beta»)-(434-16-2)
EPA Substance Registry System	Cholesta-5,7-dien-3-ol, (3.beta.)- (434-16-2)

SAFETY

Risk and Safety Statements

Safety Statements	24/25
WGK Germany	3
RTECS	FZ5650000
F	8-10-23
HS Code	29061990

7-Dehydrocholesterol price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	S296007	17-(1,5-DIMETHYL-HEXYL)-10,13-DIMETHYL-DODECAHYDRO-CYCLOPENTA(A)PHENANTHREN-3-OL AldrichCPR	434-16-2	25MG	$28.6	2022-05-15	Buy
Sigma-Aldrich	R207918	CHOLESTA-5,7-DIEN-3-BETA-OL AldrichCPR	434-16-2	1MG	$124	2022-05-15	Buy
Sigma-Aldrich	30800	7-Dehydrocholesterol ≥95.0% (HPLC)	434-16-2	5 g	$62.8	2022-05-15	Buy
Cayman Chemical	14612	7-dehydro Cholesterol ≥90%	434-16-2	5g	$32	2022-04-27	Buy
Cayman Chemical	14612	7-dehydro Cholesterol ≥90%	434-16-2	10g	$60	2022-04-27	Buy

Product number	Packaging	Price	Buy
S296007	25MG	$28.6	Buy
R207918	1MG	$124	Buy
30800	5 g	$62.8	Buy
14612	5g	$32	Buy
14612	10g	$60	Buy

7-Dehydrocholesterol Chemical Properties,Uses,Production

Description

7-dehydro Cholesterol (7-DHC) is an immediate precursor of cholesterol. It is reduced to cholesterol by the enzyme 3β-hydroxysterol-Δ⁷-reductase (DHCR7) in the last step of cholesterol biosynthesis. 7-DHC accumulates in Smith-Lemli-Opitz syndrome (SLOS), a disorder characterized by a mutation in the DHCR7 gene and decreased cholesterol levels in bodily tissues and fluids, as well as microcephaly, intellectual disability, and distinctive dysmorphic features. It is highly susceptible to free radical oxidation, giving rise to several oxysterols that may be involved in the pathogenesis of SLOS. 7-DHC levels are increased in brain, liver, and serum in a rat model of SLOS induced by the DHCR7 inhibitor AY 9944 (Item No. 14611). 7-DHC is a provitamin that is converted to vitamin D₃ (Item No. 11792) by ultraviolet-B (UVB) light in a human skin equivalent system and in isolated human skin samples.

Chemical Properties

white to off-white fine crystalline powder

Uses

A vitamin precursor.
Vitamin D3 is produced by the action of sunlight or ultraviolet irradiation from the precursor, 7-dehydrocholesterol (7-DC), that is synthesized in the skin of animals and humans.
In most tissues of the body, 7-dehydrocholesterol is the immediate precursor of cholesterol. It is reduced to cholesterol by the enzyme 3β-hydroxysterol-Δ7-reductase (DHCR7) in the last step of cholesterol biosynthesis. 7-DHC accumulates in Smith-Lemli-Opitz syndrome (SLOS), a disorder characterized by a mutation in the DHCR7 gene and decreased cholesterol levels in bodily tissues and fluids, as well as microcephaly, intellectual disability, and distinctive dysmorphic features. It is highly susceptible to free radical oxidation, giving rise to several oxysterols that may be involved in the pathogenesis of SLOS. 7-DHC levels are increased in brain, liver, and serum in a rat model of SLOS induced by the DHCR7 inhibitor AY 9944. 7-DHC is a provitamin that is converted to vitamin D3 by ultraviolet-B (UVB) light in a human skin equivalent system and in isolated human skin samples.

Uses

A vitamin D3 precursor.

Uses

7-Dehydrocholesterol (7-DHC), a 5,7-conjugated diene sterol is a biosynthetic precursor of cholesterol. It helps in the production of vitamin D3 when exposed to ultraviolet B (UVB) radiation. 7-Dehydrocholesterol has been used as an internal standard to determine sterols.
7-dehydrocholesterol is used in the diagnosis of Smith-Lemli-Opitz syndrome. Blood and tissue of infants with Smith- Lemli-Opitz (SLO) syndrome contain reduced amounts of cholesterol and greatly increased concentrations of 7-dehydrocholesterol and of its isomer 8-dehydrocholesterol.

General Description

7-Dehydrocholesterol (7-DHC), a 5,7-conjugated diene sterol is a biosynthetic precursor of cholesterol. It helps in the production of vitamin D₃ when exposed to ultraviolet B (UVB) radiation.

Biochem/physiol Actions

Down-regulates cholesterol biosynthesis in cultured Smith-Lemi-Opitz syndrome skin fibroblasts.

7-Dehydrocholesterol synthesis

Synthesis of 7-Dehydrocholesterol from 7-DEHYDROCHOLESTEROL ACETATE

7-Dehydrocholesterol Preparation Products And Raw materials

Raw materials

Cholesterol

Preparation Products

Vitamin D3 Δ8(14)-Cholestenol (3beta,6Z)-9,10-secocholesta-5(10),6,8-trien-3-ol LATHOSTEROL DELTA-4,6-CHOLESTADIENOL (30 MG)

7-Dehydrocholesterol Suppliers

Global( 235)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Wuhan Boye Science And Technology Development Co., Ltd.	27-81625225 +8615387090420	sumihu@boyechemicals.com	CHINA	211	58
Henan Tianfu Chemical Co.,Ltd.	0371-55170693	info@tianfuchem.com	China	22022	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29960	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	sales@sdzschem.com	CHINA	2940	58
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282 +86-19930503282	alice@crovellbio.com	China	5938	58
Xi'an Kono chem co., Ltd.,	029-86107037 13289246953	info@konochemical.com	CHINA	3000	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14344	58
BOC Sciences	631-4854226	inquiry@bocsci.com	United States	19752	58
Chongqing Chemdad Co., Ltd	+8613650506873	sales@chemdad.com	CHINA	37442	58
Shenzhen Excellent Biotech Co., Ltd.	13480692018	ramyan@ex-biotech.com	CHINA	955	58

Supplier	Advantage
Wuhan Boye Science And Technology Development Co., Ltd.	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	58
Hebei Guanlang Biotechnology Co., Ltd.	58
Xi'an Kono chem co., Ltd.,	58
Standardpharm Co. Ltd.	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
Shenzhen Excellent Biotech Co., Ltd.	58

View Lastest Price from 7-Dehydrocholesterol manufacturers

Release date	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2021-11-30	7-Dehydrocholesterol 434-16-2	US $1269.00 / Kg/Bag	1KG	99%	1T	Baoji Guokang Bio-Technology Co., Ltd.
2021-11-30	7-Dehydrocholesterol 434-16-2	US $1190.00 / Kg/Bag	1KG	95%	1T	Baoji Guokang Bio-Technology Co., Ltd.
2021-11-11	7-Dehydrocholesterol 434-16-2	US $10.00 / Kg/Bag	1Kg/Bag	99%	20 Tons	Hebei Zhanyao Biotechnology Co. Ltd

7-Dehydrocholesterol
434-16-2
US $1269.00 / Kg/Bag
99%
Baoji Guokang Bio-Technology Co., Ltd.

7-Dehydrocholesterol
434-16-2
US $1190.00 / Kg/Bag
95%
Baoji Guokang Bio-Technology Co., Ltd.

7-Dehydrocholesterol
434-16-2
US $10.00 / Kg/Bag
99%
Hebei Zhanyao Biotechnology Co. Ltd

7-Dehydrocholesterol Spectrum

7-Dehydrocholesterol(434-16-2)¹³CNMR 7-Dehydrocholesterol(434-16-2)IR1

434-16-2(7-Dehydrocholesterol)Related Search:

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TRANS-4-ETHYL-2-HEXENE hexadecene Isododecane 3-TRIDECANOL 2-METHYL-1-UNDECENE

1-ETHYL-3-METHYLCYCLOHEXANE CIS-1,3-DIMETHYLCYCLOHEXANE 1,4-DIMETHYLCYCLOHEXA-1,3-DIENE 10-UNDECEN-1-OL N-NONYLCYCLOHEXANE

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(3)-7-Dehydrochlesterol (3beta)-Cholesta-5,7-dien-3-ol (3-beta)-cholesta-7-dien-3-ol (3beta)-cholesta-7-dien-3-ol 3-Hydroxycholesta-5,7-diene cholesta-5,7-dien-3-beta-ol Cholesta-5,7-dien-3-ol Cholesta-5,7-dien-3-ol, (3beta)- Cholesterol, 7-dehydro- Dehydrocholesterin Dehydrocholesterol delta(sup5,7)-cholesterol delta(sup7)-cholesterol DELTA5,7-Cholestadien-3beta-ol delta5,7-Cholesterol 5,7-Cholestandien-3.beta.-ol 5,7-Cholestandien-3beta-ol 7,8-Didehydrocholesterol 7-Dehydrocholesterin 7-dehydro-cholestero 7-dien-3-ol,(3.beta.)-Cholesta-5 7-Dehydrochlesterol Provitamin D₃ 7-Dehydrocholesterol, contains ca. 1 mole of methanol of crystallization, 97.50% 10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,9,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol 7-DEHYDROCHOLESTEROL (7-DHC) (-)-7-Dehydrocholesterol, 3β-Hydroxy-5,7-cholestadiene, 5,7-Cholestadien-3β-ol, Provitamin D3 3beta-Hydroxycholesta-5,7-diene 7-Dehydrocholesterol, 97.5%, contains ca. 1 mole of methanol of crystallization 7-Dehydrocholesterol, contains ca. 1 mole of methanol of crystallization Δ5,7-Cholesterol Δ7-Cholesterol 7-DehydrocholesterolProvitamine 7-Dehydrocholseterol 7-Dehydrocholesterolmonohydrate,97% (3b)-7-Dehydrocholesterol 7-Dehydrocholesterol, contains ca. 1 mole of methanol of crystallization, 97.5% (3β)-7-Dehydro Cholesterol 7-Dehydrocholesterol, contains ca. 1 Mole of Methanol of crystallization, 97.5% 5GR 7-DHC IMp. B (EP): Cholesta-5,7-dien-3β-ol(7,8-Didehydrocholesterol 7-Dehydrocholesterol (Provitamin D3) DEHYDROCHOLESTEROL, 7-(AS) 7-Dehydrocholesterol (ProvitaMin D) (3-beta)-7-Dehydrocholesterol (Cholesta-5,7-dien-3-beta-ol) 7-Dehydrocholesterol - min95% Cholecalciferol Impurity 2（Cholecalciferol EP Impurity B） 3-beta-7-Dehydro Cholesterol Cholecalciferol EP Impurity B delta7-Cholesterol Provitamin D(sub 3) provitamind(sub3) DEHYDROCHOLESTEROL, 7- (-)-7-DEHYDROCHOLESTEROL 7-DEHYDROCHOLESTEROL 7-DEHYDROCHOLESTEROL MONOHYDRATE 5,7-CHOLESTADIEN-3-BETA-OL MONOHYDRATE 5,7-CHOLESTADIEN-3BETA-OL